|1.||Wakita, Takaji: 2 articles (05/2015 - 12/2014)|
|2.||Watashi, Koichi: 2 articles (05/2015 - 12/2014)|
|3.||Royle, Stephen J: 2 articles (06/2011 - 04/2005)|
|4.||Tateno, Chise: 1 article (05/2015)|
|5.||Yoshizane, Yasumi: 1 article (05/2015)|
|6.||Ishida, Yuji: 1 article (05/2015)|
|7.||Chayama, Kazuaki: 1 article (05/2015)|
|8.||Yanagi, Ami: 1 article (05/2015)|
|9.||Hayes, C Nelson: 1 article (05/2015)|
|10.||Fujikawa, Kazuyuki: 1 article (05/2015)|
01/01/2010 - "We found that CHIKV infection of HEK293T mammalian cells is independent of clathrin heavy chain and- dependent of functional Eps15, and requires integrity of Rab5-, but not Rab7-positive endosomal compartment. "
12/05/2007 - "Evidence of a direct requirement of clathrin for productive viral entry was obtained using BHK21-tTA/anti-CHC cells, which showed a significant reduction of viral entry and infection when the synthesis and functionality of clathrin heavy chain was inhibited (Tet- cells). "
12/01/2014 - "Interestingly, knockdown of the clathrin heavy chain or dynamin-2 (Dyn2), as well as expression of the dominant-negative form of Dyn2, reduced infection of Huh-7 cells with HCVtcp, whereas infectious entry of HCVtcp into Huh7.5.1 cells was not impaired. "
03/01/2014 - "The infection was also reduced by silencing the expression of the clathrin heavy chain (CHC) by RNA interference or by overexpression of dominant-negative mutants of dynamin 2 and Eps15. "
06/01/2012 - "As expected, mutants in genes known to be involved in virus internalization and trafficking [Clathrin heavy chain (chc) and synaptotagmin] survive longer during infection. "
|2.||Autoimmune Diseases (Autoimmune Disease)
06/01/2011 - "Two different gene fusions involving clathrin heavy chain (CHC) have been described in human cancers. "
06/01/2011 - "Clathrin heavy chain gene fusions expressed in human cancers: analysis of cellular functions."
10/08/2004 - "Tumors exhibited increased association of Egfr with clathrin heavy chain (CHC), Gab1, and p85alpha, the regulatory subunit of phosphoinositide 3-kinase (PI3K), and tumors also overexpressed c-Src, PDK1, and Akt. "
08/01/2001 - "Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor."
04/28/2005 - "The importance of clathrin for normal mitosis may be relevant to understanding human cancers that involve gene fusions of clathrin heavy chain."
|4.||Hepatocellular Carcinoma (Hepatoma)
07/01/2011 - "Clathrin heavy chain (CHC) staining for the diagnosis of small hepatocellular carcinoma."
05/01/2011 - "Diagnostic accuracy of clathrin heavy chain staining in a marker panel for the diagnosis of small hepatocellular carcinoma."
01/01/2015 - "The HCV-induced autophagy response, as well as treatment with Torin 1, degrades clathrin heavy chain expression in a hepatoma cell line. "
08/01/2008 - "Identification of novel immunohistochemical tumor markers for primary hepatocellular carcinoma; clathrin heavy chain and formiminotransferase cyclodeaminase."
01/01/2008 - "Previously a chicken pre-B lymphoma cell line (DKO-R) was developed in which the endogenous clathrin heavy chain alleles were replaced with the human clathrin heavy chain under the control of a tetracycline-regulatable promoter. "
05/15/2000 - "A cloned complementary DNA sequence from 1 of these 2 lymphomas contained the ALK gene fused to the second clathrin heavy chain gene (also referred to as clathrin heavy polypeptide-like gene) (CLTCL). "
08/01/2003 - "As 2;17 translocation resulting in the fusion of clathrin heavy chain (CLTC) gene with ALK was previously reported in inflammatory myofibroblastic tumor, we performed reverse transcriptase-polymerase chain reaction and demonstrated that the lymphoma cells contained CLTC-ALK fusion transcript. "
|2.||Small Interfering RNA (siRNA)
|4.||Complementary DNA (cDNA)
|7.||anaplastic lymphoma kinase