Periplasmic Binding Proteins

Periplasmic proteins that scavenge or sense diverse nutrients. In the bacterial environment they usually couple to transporters or chemotaxis receptors on the inner bacterial membrane.

Also Known As:

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Balan, Andrea: 2 articles (01/2017 - 08/2014)
2.	Funahashi, Tatsuya: 1 article (12/2021)
3.	Hiromoto, Takeshi: 1 article (12/2021)
4.	Kawano, Hiroaki: 1 article (12/2021)
5.	Komano, Jun: 1 article (12/2021)
6.	Miyamoto, Katsushiro: 1 article (12/2021)
7.	Miyano, Nao: 1 article (12/2021)
8.	Okai, Naoko: 1 article (12/2021)
9.	Tanabe, Tomotaka: 1 article (12/2021)
10.	Tomoo, Koji: 1 article (12/2021)

Related Diseases

1.	Brain Diseases (Brain Disorder) 01/01/2023 - "In order to study the functional roles of neuromodulatory transmitters in animal behaviors and brain disorders, new fluorescent sensors based on bacterial periplasmic binding proteins (PBPs) and G-protein coupled receptors have been developed, but their results have not been compared to or multiplexed with traditional methods such as electrophysiological recordings. "
2.	Starvation 06/01/2007 - "Although TauA shares few common characteristics with other known periplasmic binding protein, TauA is a putative periplasmic binding protein, part of tauABCD gene cluster involved in sulfonate transport in sulphate starvation condition. " 01/01/2000 - "Both systems were inducible by P(i) starvation and were also shock sensitive, which indicated that there was a periplasmic binding-protein component. " 08/28/2014 - "Analysis performed under phosphate starvation provided evidence of the relevance of the Pst system for phosphate uptake, as well as both periplasmic binding proteins, PhoX and PstS, which were formed in high abundance. " 11/01/2012 - "Under phosphate starvation conditions, Escherichia coli can utilize sn-glycerol-3-phosphate (G3P) and G3P diesters as phosphate source when transported by an ATP binding cassette importer composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. "
3.	Shock 04/05/1977 - "The present results are consistent with models for the action of periplasmic-binding proteins in shock-sensitive transport systems of gram-negative bacteria which require a substrate-induced conformational change prior to the energy-dependent translocation of substrates." 01/01/2000 - "Both systems were inducible by P(i) starvation and were also shock sensitive, which indicated that there was a periplasmic binding-protein component. " 01/01/1989 - "Methionine transport was strongly inhibited by arsenate, suggesting that the metP system belongs to the shock-sensitive category and possesses a periplasmic binding protein. "
4.	Infections 01/01/2017 - "In this work, based on gene reporter and proteomics analyses, we showed the activation of the promoter that controls the sbpcysUWA operon in vitro and in vivo and the expression of sulfate-binding protein (Sbp), a periplasmic-binding protein, indicating that this protein plays an important function during growth and that the transport system is active during Citrus sinensis infection. " 01/01/2014 - "melitensis proteins (BMEI 1330, a DegP/HtrA protease; BMEII 0029, type IV secretion system component VirB5; and BMEII 0691, a predicted periplasmic binding protein of a peptide transport system) were found repeatedly to produce significant IFN-γ ELISPOT responses in both acute-infection and relapsing patients; none of the peptides distinguished the patient groups. "
5.	Cystic Fibrosis (Mucoviscidosis) 07/26/1990 - "This superfamily includes the well characterized periplasmic binding protein-dependent uptake systems of prokaryotes, bacterial exporters, and eukaryotic proteins including the P-glycoprotein associated with multidrug resistance in tumours (MDR), the STE6 gene product that mediates export of yeast a-factor mating pheromone, pfMDR that is implicated in chloroquine resistance of the malarial parasite, and the product of the cystic fibrosis gene (CFTR). " 05/01/1993 - "The plasmid-determined arsenite and antimonite efflux ATPase of bacteria differs from other membrane transport ATPases, which are classified into several families (such as the F0F1-type H(+)-translocating ATP synthases, the related vacuolar H(+)-translocating ATPases, the P-type cation-translocating ATPases, and the superfamily which includes the periplasmic binding-protein-dependent systems in Gram-negative bacteria, the human multidrug resistance P-glycoprotein, and the cystic fibrosis transport regulator). "

Related Drugs and Biologics

1.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
2.	Proteins (Proteins, Gene)
3.	Adenosine Triphosphate (ATP)
4.	Member 1 Subfamily B ATP Binding Cassette Transporter
5.	Phosphates (Orthophosphate)
6.	Membrane Transport Proteins (Biological Pump)
7.	Siderophores
8.	Sulfates (Sulfates, Inorganic)
9.	Pheromones (Semiochemicals)
10.	Peptides (Polypeptides)