Equilibrative-Nucleoside Transporter 2

A subtype of equilibrative nucleoside transporter proteins that is insensitive to inhibition by 4-nitrobenzylthioinosine.

Also Known As:

Equilibrative, Nitrobenzylmercaptopurine Riboside (NBMPR)-Insensitive Nucleoside Transporter; Nitrobenzylmercaptopurine Riboside (NBMPR)-Insensitive, Equilibrative Nucleoside Transporter; SLC29A2 Protein; Solute Carrier-Family 29 (Nucleoside Transporters), Member 2

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Solute Carrier Proteins: 34
        Equilibrative Nucleoside Transport Proteins
        Equilibrative-Nucleoside Transporter 2: 8
        C elegans equilibrative nucleoside transporter 2
        human SLC29A2 protein
        mouse Slc29a2 protein
        rat Slc29a2 protein
      - Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins
        Nucleoside Transport Proteins: 164
        Equilibrative Nucleoside Transport Proteins
        Equilibrative-Nucleoside Transporter 2: 8
        C elegans equilibrative nucleoside transporter 2
        human SLC29A2 protein
        mouse Slc29a2 protein
        rat Slc29a2 protein
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Solute Carrier Proteins: 34
        Equilibrative Nucleoside Transport Proteins
        Equilibrative-Nucleoside Transporter 2: 8
        C elegans equilibrative nucleoside transporter 2
        human SLC29A2 protein
        mouse Slc29a2 protein
        rat Slc29a2 protein
      - Nucleobase, Nucleoside, Nucleotide, and Nucleic Acid Transport Proteins
        Nucleoside Transport Proteins: 164
        Equilibrative Nucleoside Transport Proteins
        Equilibrative-Nucleoside Transporter 2: 8
        C elegans equilibrative nucleoside transporter 2
        human SLC29A2 protein
        mouse Slc29a2 protein
        rat Slc29a2 protein

Experts

1.	Bendayan, Reina: 1 article (01/2016)
2.	Brassard, Pierre: 1 article (01/2016)
3.	Bélanger, Maud: 1 article (01/2016)
4.	Chomont, Nicolas: 1 article (01/2016)
5.	Fletcher, Courtney V: 1 article (01/2016)
6.	Hoque, Md Tozammel: 1 article (01/2016)
7.	Huang, Yiying: 1 article (01/2016)
8.	Jenabian, Mohammad-Ali: 1 article (01/2016)
9.	Routy, Jean-Pierre: 1 article (01/2016)
10.	Sheehan, Nancy L: 1 article (01/2016)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2023 - "Although the purine metabolism pathway is vital for cancer cell survival, little is known about the role of equilibrative nucleoside transporter 2 (ENT2) in CRC development and its association with purine metabolites. " 03/01/2015 - "We show here that genetic manipulations with the AdoR, equilibrative nucleoside transporter 2 (Ent2), and Ado deaminase growth factor-A (Adgf-A) cause dramatic changes in the frequency of hyperplastic outgrowth clones formed by LOH of the warts (wts) tumor suppressor, while they have almost no effect on control yellow (y) clones. "
2.	Hypoxia (Hypoxemia) 02/01/2009 - "Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia." 10/01/2014 - "Hypoxic IECs showed reduced levels of equilibrative nucleoside transporter 2 (ENT2), OCTN2, and SERT mRNAs in vitro, which was confirmed on the protein level and was accompanied by activation of ERK1/2, increase of hypoxia-inducible factor (HIF) proteins, and production of IL-8 mRNA. "
3.	Disease Progression 01/01/2023 - "Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease."
4.	T-Cell Leukemia (Leukemia, T Cell) 07/22/2011 - "Exposure of MOLT4 human T-cell leukemia cells to 6-Mercaptopurine (6-MP) and 6-Thioguanine (6-TG) resulted in acquired resistance associated with attenuated expression of the genes encoding concentrative nucleoside transporter 3 (CNT3) and equilibrative nucleoside transporter 2 (ENT2). "
5.	Warts (Wart) 03/01/2015 - "We show here that genetic manipulations with the AdoR, equilibrative nucleoside transporter 2 (Ent2), and Ado deaminase growth factor-A (Adgf-A) cause dramatic changes in the frequency of hyperplastic outgrowth clones formed by LOH of the warts (wts) tumor suppressor, while they have almost no effect on control yellow (y) clones. "

Related Drugs and Biologics

1.	Nucleoside Transport Proteins (Nucleoside Transporter)
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	Cytochrome P-450 CYP3A
5.	Intercellular Signaling Peptides and Proteins (Growth Factors)
6.	Organic Anion Transporters
7.	Member 1 Subfamily B ATP Binding Cassette Transporter
8.	Cytochrome P-450 CYP2D6 (CYP2D6)
9.	Complementary DNA (cDNA)
10.	Interleukin-8 (Interleukin 8)