Stem Cell Transplantation

The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.

Also Known As:

Networked: 14395 relevant articles (1425 outcomes, 1547 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Kröger, Nicolaus: 180 articles (10/2022 - 08/2002)
2.	Mohty, Mohamad: 166 articles (10/2022 - 11/2002)
3.	Nagler, Arnon: 155 articles (10/2022 - 01/2002)
4.	Blaise, Didier: 125 articles (06/2022 - 10/2002)
5.	Labopin, Myriam: 115 articles (10/2022 - 02/2003)
6.	Dreger, Peter: 90 articles (02/2022 - 03/2003)
7.	Dispenzieri, Angela: 82 articles (11/2022 - 11/2002)
8.	Gertz, Morie A: 81 articles (11/2022 - 06/2002)
9.	Yakoub-Agha, Ibrahim: 74 articles (07/2022 - 01/2006)
10.	Champlin, Richard E: 70 articles (12/2022 - 01/2002)

Related Diseases

1.	Multiple Myeloma 01/02/2022 - "High-dose chemotherapy and stem cell transplantation are the best treatment options in patients with multiple myeloma. " 06/01/2015 - "High-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) is the most common first-line treatment for patients with multiple myeloma (MM) under 65 years of age. " 10/01/2012 - "Autologous stem cell transplantation and novel therapies have improved overall survival of patients with multiple myeloma; however, most patients relapse and eventually succumb to their disease. " 12/01/2010 - "In 2000, the most important therapeutic improvement in multiple myeloma (MM) had been the introduction of high-dose therapy (HDT) supported by autologous stem cell transplantation, but this strategy was proposed only to younger patients without comorbidities. " 11/15/2008 - "Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation."
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/01/2006 - "Most studies showing that autologous stem cell transplantation (ASCT) is feasible in older patients with acute myeloid leukemia (AML) referred to highly selected patients considered as eligible after complete remission (CR) achievement and bone marrow or peripheral blood stem cell (PBSC) collection. " 01/01/2022 - "As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best chance for durable remission in older patients (≥60 years) with acute myeloid leukemia (AML). " 01/01/2018 - "The CMV-induced generation of highly differentiated adaptive-like NK cells has been proposed to affect favorably on the maintenance of remission in patients with acute myeloid leukemia (AML) after allogeneic stem cell transplantation (allo-SCT). " 10/01/2014 - "Stem cell transplantation is still the most effective treatment for pediatric acute myeloid leukemia (AML). " 04/01/2008 - "Our period analysis reveals major improvement on the population level in long-term prognosis of younger patients with acute myeloblastic leukemia, most likely explained by multiple incremental improvements in care including better and more specific diagnosis, improvements in and extension of the use of stem cell transplantation and high dose therapy, and improved supportive care."
3.	Neoplasms (Cancer) 02/01/2022 - "Approximately 60% of patients are cured using standard chemotherapy (CT), while in 10-15% of cases, the tumor is characterized by an extremely aggressive course and resistance to even the most high-dose programs with autologous stem cell transplantation (auto-SCT). " 07/25/2018 - "Haematopoietic stem cell transplantation (HSCT) remains the only cure for most haematological malignancies, however, the mortality rate remains high. " 08/01/2005 - "The cumulative experience over the years suggesting that alloreactive donor lymphocytes were most effective in eliminating tumor cells of host origin resulted in an attempt to reduce the intensity of the conditioning in preparation for the transplant procedure used for the treatment of hematological and other malignancies as well as life-threatening non-malignant disorders for which allogeneic stem cell transplantation may be indicated. " 06/01/2006 - "The aim of the study was to evaluate the feasibility and efficacy of a non-myeloablative regimen to achieve complete donor chimerism after stem cell transplantation (SCT) in patients with metastatic solid tumors. " 02/01/2002 - "Preliminary clinical studies have shown that patients previously ineligible for allogeneic stem cell transplantation can frequently be safely transplanted and that an immune-mediated graft-versus-malignancy effect plays an important role in the antitumor efficacy of this treatment. "
4.	Lymphoma (Lymphomas) 01/01/2018 - "The results of this study demonstrate the need for high awareness of HLH in patients with panniculitic lymphomas and indicate that allogeneic stem cell transplantation may be the best option for a sustained remission." 05/01/2013 - "High-dose chemotherapy followed by autologous stem cell transplantation is a highly effective and safe treatment modality for selected primary central nervous system lymphoma patients. " 05/01/2013 - "High-dose chemotherapy followed by autologous stem cell transplantation has been shown to be feasible and highly effective in newly diagnosed primary central nervous system lymphoma. " 05/04/2021 - "The value of complete remission according to positron emission tomography prior to autologous stem cell transplantation in lymphoma: a population-based study showing improved outcome." 01/01/2023 - "Second breakthrough is an increase of autologous stem cell transplantation usage in the first complete metabolic remission, except in ALK + anaplastic large cell lymphoma, offering better disease control. "
5.	Leukemia 01/01/2014 - "Allogeneic stem cell transplantation (alloSCT) is the most robust form of adoptive cellular therapy (ACT) and has been tremendously effective in the treatment of leukemia. " 10/01/2021 - "Allogeneic stem cell transplantation for AML patients with RUNX1 mutation in first complete remission: a study on behalf of the acute leukemia working party of the EBMT." 01/01/2017 - "Allogeneic stem cell transplantation in adult patients with acute myeloid leukaemia and 17p abnormalities in first complete remission: a study from the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT)." 01/01/2022 - "We report on 318 patients with acute leukemia, receiving donor lymphocyte infusion (DLI) in complete hematologic remission (CHR) after allogeneic stem cell transplantation (alloSCT). " 01/01/2018 - "Comparable results of autologous and allogeneic haematopoietic stem cell transplantation for adults with Philadelphia-positive acute lymphoblastic leukaemia in first complete molecular remission: An analysis by the Acute Leukemia Working Party of the EBMT."

Related Drugs and Biologics

1.	Melphalan (Alkeran)
2.	Cyclophosphamide (Cytoxan)
3.	Rituximab (Mabthera)
4.	Bortezomib (Velcade)
5.	Thalidomide (Thalomid)
6.	Dexamethasone (Maxidex)
7.	Lenalidomide (CC 5013)
8.	Cytarabine (Cytosar-U)
9.	Etoposide (VP 16)
10.	Busulfan (Busulfex)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Transplantation
4.	Radiotherapy
5.	Immunotherapy