Tuberculosis Vaccines

10/15/2007 - "Given that Th cells play a major role in protection against tuberculosis, rBCG-hcs would be a valuable tuberculosis vaccine candidate."
02/01/1999 - "Because CD8 T cells play a major role in protection against tuberculosis such Hly-secreting r-BCG constructs are anti-tuberculosis vaccine candidates. "
02/01/2003 - "Therefore it is possible to achieve a greater level of protection against tuberculosis than with BCG, and this highlights the potential for new tuberculosis vaccines in humans."
09/01/2011 - "There is an urgent need for a new, safe and effective tuberculosis vaccine that prevents all forms of tuberculosis, in all age groups and in HIV-infected people. "
01/01/2009 - "tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques."

12/06/2016 - "The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term metabolic changes and chromatin remodeling through histone modifications in innate immune cells such as monocytes, a process termed trained immunity. "
09/25/2001 - "To assess the relative merits of rhesus and cynomolgus monkeys as screens for tuberculosis vaccines, we compared the efficacy of bacillus Calmette-Guérin vaccination and the course of infection in both species. "
01/01/2015 - "A new tuberculosis vaccine is needed to replace or enhance BCG, which induces variable protection against Mycobacterium tuberculosis pulmonary infections in adults. "
07/30/2009 - "The potential impact of helminth infection on trials of novel tuberculosis vaccines."
09/25/2001 - "The complicated and often protracted dynamics of infection and disease make clinical trials to test new tuberculosis vaccines extremely complex. "

06/01/2009 - "Immunization with a bivalent adenovirus-vectored tuberculosis vaccine provides markedly improved protection over its monovalent counterpart against pulmonary tuberculosis."
01/01/2009 - "In early clinical studies, the live tuberculosis vaccine Mycobacterium bovis BCG exhibited 80% protective efficacy against pulmonary tuberculosis (TB). "
01/01/2022 - "The M72/AS01E tuberculosis vaccine showed 50% (95%CI: 2-74%) efficacy in a phase 2B trial in preventing active pulmonary tuberculosis disease, but potential cost-effectiveness of adolescent immunisation is unknown. "
03/01/2009 - "Specimen-collection methods for bacteriological confirmation of pulmonary tuberculosis (PTB) were compared during a tuberculosis vaccine trial near Cape Town, South Africa (2001-2006). "
03/01/2011 - "The anti-tuberculosis vaccine, Mycobacterium bovis BCG, has been used worldwide, but its protective efficacy is variable against adult pulmonary tuberculosis. "

02/01/2011 - "Will new tuberculosis vaccines provide protection against leprosy?"
03/01/2002 - "There have been no formal surveys in the Songwe area since the 1960s but an opportunity arose in 2000-2001 to map LF in this area, in the context of a leprosy survey that formed part of the follow-up of a large leprosy and tuberculosis vaccine trial. "
12/01/1993 - "In this report the methods of the Karonga Prevention Trial, a double-blind leprosy and tuberculosis vaccine trial in Karonga District, Northern Malaŵi, are described in detail. "
12/01/1993 - "The Karonga Prevention Trial: a leprosy and tuberculosis vaccine trial in northern Malaŵi. "
09/01/1989 - "Leprosy and tuberculosis vaccine design."

03/28/2018 - "Infectious disease: Virus-based tuberculosis vaccine."
08/01/2015 - "Despite the availability of potent drugs and the availability of vaccine, tuberculosis remains until today one of the most worrying infectious diseases because of both its morbidity and mortality. "
04/14/2009 - "Hussey is a Paediatric Infectious Diseases Clinical Specialist and Professor of Child and Adolescent Health, Director of the Institute of Infectious Disease and Molecular Medicine, and Director of the South African Tuberculosis Vaccine Initiative, University of Cape Town, South Africa. "
01/01/2006 - "Despite advances in chemotherapy and the BCG (Bacillus Calmette-Guérin) vaccine, tuberculosis remains a significant infectious disease. "
01/04/2023 - "Trials from areas with high incidence rates for infectious diseases indicated that the tuberculosis vaccine Bacillus Calmette-Guérin (BCG) induces in addition non-specific immunity against various pathogens and thereby reduces overall mortality more than would have been expected by just protecting from tuberculosis. "