Peroxynitrous Acid (Peroxynitrite)

A potent oxidant synthesized by the cell during its normal metabolism. Peroxynitrite is formed from the reaction of two free radicals, NITRIC OXIDE and the superoxide anion (SUPEROXIDES).

Also Known As:

Networked: 2068 relevant articles (60 outcomes, 256 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Szabó, Csaba: 34 articles (06/2012 - 05/2002)
2.	Salvemini, Daniela: 33 articles (10/2021 - 06/2002)
3.	Cuzzocrea, Salvatore: 32 articles (12/2014 - 02/2002)
4.	Shen, Jiangang: 18 articles (04/2022 - 10/2013)
5.	Radi, Rafael: 16 articles (01/2019 - 03/2002)
6.	Esposito, Emanuela: 16 articles (12/2014 - 10/2006)
7.	Tokuda, Harukuni: 16 articles (12/2013 - 04/2002)
8.	Yang, Dan: 14 articles (01/2021 - 01/2010)
9.	Liaudet, Lucas: 14 articles (03/2013 - 05/2002)
10.	Jaeschke, Hartmut: 13 articles (01/2022 - 11/2002)

Related Diseases

1.	Inflammation (Inflammations) 02/26/1999 - "Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation. " 01/01/2020 - "Previous studies have shown that LF can be efficiently nitrated via biologically relevant mediators such as peroxynitrite (ONOO- ), which are also present at high intracellular concentrations during inflammation and nitrosative stress. " 03/26/2019 - "Therefore, this study indicates that peroxynitrite may mediate the inhibition of ASCT1 and B0AT1 during inflammation, when OONO levels are known to be elevated in the mucosa." 12/15/2022 - "Abnormal intracellular peroxynitrite (ONOO-) concentration is related to oxidative damage, which is correlated with many pathological consequences, such as local inflammation and other diseases. " 01/01/2021 - "Highly Sensitive Near-Infrared Imaging of Peroxynitrite Fluxes in Inflammation Progress."
2.	Reperfusion Injury 01/01/1997 - "Conversely, other studies suggest that NO exacerbates reperfusion injury by inducing the production of peroxynitrite. " 07/01/2015 - "Rapid ventricular pacing-induced postconditioning attenuates reperfusion injury: effects on peroxynitrite, RISK and SAFE pathways." 01/01/2008 - "Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury." 03/01/2004 - "Hepatoenteric ischemia-reperfusion injury is associated with peroxynitrite (OONO(-)) formation, coagulopathy and decreased TF activity in rabbits. " 07/01/2003 - "The deleterious effects of lung ischemia-reperfusion injury are in part mediated by the formation of peroxynitrite, as enhanced decomposition of this species is protective in this model. "
3.	Ischemia 04/01/2007 - "The use of the peroxynitrite decomposition catalyst (FeTPPS) may help to improve myocardial preservation during a prolonged ischemia sequence." 11/01/2010 - "Because the renal ischemic injury is associated with outer medullary (OM) endothelial dysfunction, the present study evaluated sex differences in OM changes of NO and peroxynitrite levels (by differential pulse voltammetry and amperometry, respectively) during 45 min of ischemia and 60 min of reperfusion in anesthetized Sprague-Dawley rats. " 05/12/2003 - "Recent studies have shown that peroxynitrite is the primary mediator of DNA damage and, hence, PARP activation after ischemia. " 04/01/1999 - "In the present study we show for the first time a significant decrease of the octamer/dimer ratio in vivo, related to ischemia-induced damage, and a similar decrease of octamer stability in vitro, induced by peroxynitrite (PN) radicals. " 11/01/1997 - "This study examined the effects of peroxynitrite (ONOO-) on cardiac function and cellular injury following ischemia (30 min) and reperfusion (60 min) in isolated perfused rat hearts. "
4.	Neoplasms (Cancer) 07/10/2019 - "DDC-loaded THoR-NP, in combination with SNP treatment, eliminated multiple cancer cell lines effectively by the generation of peroxynitrite in the cells (>95% cell death), as compared to control drug treatments of the same concentration of DDC or SNP alone (0% cell death). " 09/15/2012 - "Recent studies have shown the important role of ROS and RNS, especially peroxynitrite, in immune suppression in cancer. " 11/01/2023 - "Thus, this work presents a superior paradigm for designing peroxynitrite-boosted ferroptosis sensitization cancer therapeutic." 03/22/2023 - "The decomposed endogenous H2O2 generates several different types of reactive species (•OH, O2•-) including peroxynitrite (ONOO-) species as apoptotic inducers that kill cancer cells, specifically. " 11/09/2022 - "Moreover, NO can transform to more cytotoxic peroxynitrite to destroy cancer cells. "
5.	Septic Shock (Toxic Shock Syndrome) 03/01/2013 - "The formation of peroxynitrite is a key pathophysiological mechanism contributing to the cardiovascular collapse of septic shock, promoting vascular contractile failure, endothelial and myocardial dysfunction, and is also implicated in the occurrence of multiple organ dysfunction in this setting. " 03/01/2013 - "Role of peroxynitrite in the cardiovascular dysfunction of septic shock." 02/01/2011 - "The peroxynitrite catalyst WW-85 improves pulmonary function in ovine septic shock." 04/24/1995 - "Our data suggest that during endotoxin shock, part of .NO, produced following the induction of iNOS, is converted into peroxynitrite in the vicinity of large blood vessels. " 08/01/2011 - "This prospective, randomized, controlled experimental study examined the effects of the peroxynitrite decomposition catalyst WW-85 on global hemodynamics and regional microvascular blood flow (RMBF) in an established ovine model of septic shock following severe smoke inhalation injury. "

Related Drugs and Biologics

1.	Superoxides (Superoxide)
2.	Melatonin
3.	Antioxidants
4.	Nitric Oxide Synthase (NO Synthase)
5.	Anions
6.	manganese(III)-tetrakis(4-benzoic acid)porphyrin
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
9.	Proteins (Proteins, Gene)
10.	Free Radicals

Related Therapies and Procedures

1.	Baths
2.	Therapeutics
3.	Aftercare (After-Treatment)
4.	Ligation
5.	Resuscitation