|1.||Type 1 Diabetes Mellitus (Autoimmune Diabetes)
|2.||Jervell-Lange Nielsen Syndrome (Jervell and Lange-Nielsen Syndrome)
|3.||Torsades de Pointes (Torsade de Pointes)
|4.||Long QT Syndrome
|1.||Behr, Elijah R: 2 articles (10/2014 - 06/2013)|
|2.||Thomas, Dierk: 2 articles (12/2012 - 08/2005)|
|3.||Katus, Hugo A: 2 articles (12/2012 - 08/2005)|
|4.||Wasano, Koichiro: 1 article (08/2015)|
|5.||Masuda, Sawako: 1 article (08/2015)|
|6.||Mutai, Hideki: 1 article (08/2015)|
|7.||Obuchi, Chie: 1 article (08/2015)|
|8.||Matsunaga, Tatsuo: 1 article (08/2015)|
|9.||Wong, Leonie C H: 1 article (10/2014)|
|10.||Till, Janice A: 1 article (10/2014)|
|1.||Propranolol (Inderal)FDA LinkGeneric
04/01/1991 - "A case of Romano-Ward syndrome effectively treated by both propranolol and atrial pacing is reported. "
04/01/1991 - "[A case of Romano-Ward syndrome effectively treated by propranolol and atrial pacing]."
09/01/1975 - "Judging from the fact, propranolol may be the first to be administered among a variety of anti-arrhythmic agents in the Romano-Ward syndrome."
|2.||HLA-DR4 Antigen (HLA DR4 Antigen)IBA
|3.||Potassium Channels (Potassium Channel)IBA
08/15/2005 - "Dominant-negative I(Ks) suppression by KCNQ1-deltaF339 potassium channels linked to Romano-Ward syndrome."
08/07/2015 - "This genotype-phenotype correlation is analogous to that in KCNQ1 which causes autosomal dominant hereditary long QT syndrome 1 with milder phenotype and the autosomal recessive Jervell and Lange-Nielsen syndrome 1 with more severe phenotype due to deletion of the cytoplasmic C-terminus of the potassium channel. "
06/23/1998 - "Mutations of the KVLQT1 gene, a cardiac potassium channel, generate two allelic diseases: the Romano-Ward syndrome, inherited as a dominant trait, and the Jervell and Lange-Nielsen syndrome, inherited as an autosomal recessive trait. "
11/04/1997 - "KVLQT1, the gene encoding the alpha-subunit of a cardiac potassium channel, is the most common cause of the dominant form of long-QT syndrome (LQT1-type), the Romano-Ward syndrome (RWS). "
|4.||Ion Channels (Ion Channel)IBA
12/10/2012 - "Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1."
03/01/1998 - "Once limited to discussions of the Jervell and Lange-Nielsen syndrome and Romano-Ward syndrome, the long QT syndrome (LQTS) is now understood to be a collection of genetically distinct arrhythmogenic cardiovascular disorders resulting from mutations in fundamental cardiac ion channels that orchestrate the action potential of the human heart. "
|5.||Ethyl Ether (Ether)IBA
06/15/2007 - "In conclusion, the Ala490Pro mutation of the human ether-a-go-go-related gene is a rare, novel mutation that was inherited in this family, leading to Romano-Ward syndrome with complete penetrance."
07/01/2000 - "It is becoming clear that mutations in the KVLQT1, human "ether-a-go-go" related gene, cardiac voltage-dependent sodium channel gene, minK and MiRP1 genes, respectively, are responsible for the LQT1, LQT2, LQT3, LQT5 and LQT6 variants of the Romano-Ward syndrome, characterized by autosomal dominant transmission and no deafness. "
|6.||DNA (Deoxyribonucleic Acid)IBA
01/01/2008 - "We have performed DNA sequencing of the LQTS-associated genes in 169 unrelated patients referred for genetic testing with respect to Romano Ward syndrome and in 13 unrelated patients referred for genetic testing with respect to Jervell and Lange-Nielsen syndrome. "
10/20/2005 - "For Romano-Ward syndrome and Jervell and Lange-Nielsen syndrome DNA based diagnostics are available. "
|7.||Polymorphic catecholergic ventricular tachycardiaIBA
10/01/2014 - "Genetic testing identified mutations in 20% of Brugada syndrome (2/10) and 50% of long QT syndrome (1/2) and catecholaminergic polymorphic ventricular tachycardia families (1/2) who were tested. "
06/01/2013 - "Twenty-one families (51%) with autopsy findings of uncertain significance received a diagnosis based on the identification of an inherited cardiac condition phenotype in ≥1 relatives: 14 Brugada syndrome; 4 long-QT syndrome; 1 catecholaminergic polymorphic ventricular tachycardia; and 2 cardiomyopathy. "
|8.||Congenital heart blockIBA
04/01/1990 - "The prognosis of congenital complete heart block associated with QT prolongation resembles that of the Romano-Ward syndrome. "
09/01/1983 - "The subset of "congenital heart block" patients with prolonged QT interval is at high risk of sudden death and should be regarded as a previously unrecognized form of Romano-Ward syndrome."
|9.||halofantrine (Halfan)FDA Link
01/01/1993 - "In spite of the rarity on the congenital Romano-Ward syndrome, systematic electrocardiogram is necessary before giving halofantrine."
01/01/1993 - "In two cases, several bursts of torsades de pointes ventricular tachycardia due to halofantrine were proven and electrophysiological cardiac tests concluded that they had a congenital long QT-interval/Romano-Ward syndrome). "
07/01/1995 - "Halofantrine, increasingly used for treatment of Plasmodium falciparum malaria, is a normally well-tolerated amino-alcohol with very few side-effects, but torsades de pointes ventricular tachycardia due to halofantrine has been reported in a few patients with a congenital long QT interval (Romano-Ward syndrome). "
|10.||Nicorandil (SG 75)IBA
|1.||Cesarean Section (Caesarean Section)
02/01/1992 - "[Hereditary prolonged QT interval (Romano-Ward syndrome) in a female patient with non-elective cesarean section]."
08/01/1995 - "Epidural anesthesia for cesarean section in a patient with Romano-Ward syndrome."
01/01/2005 - "Successful management of cesarean section in a patient with Romano-Ward syndrome using landiolol, a selective and short-acting beta1 receptor antagonist."
|2.||Laser Therapy (Surgery, Laser)
|3.||Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
01/01/1979 - "[Romano-Ward syndrome and artificial pacemaker]."