Diamond-Blackfan Anemia (Anemia, Diamond Blackfan)

A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)
Also Known As:
Anemia, Diamond Blackfan; Anemia, Diamond-Blackfan; Anemia, Diamond-Blackfan Type; Blackfan-Diamond Syndrome; Anemia, Diamond Blackfan Type; Blackfan Diamond Syndrome; Diamond Blackfan Anemia; Diamond-Blackfan Type Anemia
Networked: 260 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Macrocytic Anemia
2. Thalassemia
3. Fanconi Anemia (Fanconi's Anemia)
4. Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita)
5. Anemia


1. Ellis, Steven R: 13 articles (03/2015 - 01/2006)
2. Gleizes, Pierre-Emmanuel: 12 articles (04/2013 - 11/2005)
3. Dianzani, Irma: 11 articles (10/2014 - 12/2004)
4. Gazda, Hanna T: 11 articles (07/2014 - 09/2006)
5. Dahl, Niklas: 11 articles (01/2011 - 01/2002)
6. Alter, Blanche P: 10 articles (10/2015 - 01/2007)
7. Karlsson, Stefan: 10 articles (12/2014 - 10/2002)
8. Ramenghi, Ugo: 10 articles (10/2014 - 12/2004)
9. Da Costa, Lydie: 10 articles (07/2014 - 01/2003)
10. Flygare, Johan: 9 articles (12/2014 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diamond-Blackfan Anemia:
1. MethylprednisoloneFDA LinkGeneric
2. Transient erythroblastopenia of childhoodIBA
12/01/1990 - "The case is discussed in the context of a diagnostic differentiation between transient erythroblastopenia of childhood (TEC) and Diamond-Blackfan Anemia (DBA); since it does not clearly fit either category it could either be an unusual TEC presentation with extended macrocytic anemia dependent on steroid therapy for remission, or a late onset DBA with potential for eventual relapse."
09/01/1987 - "The vast majority of pediatric RBC hypoplastic anemias are accounted for by red blood cell aplasia associated with chronic hemolysis, Diamond-Blackfan anemia, and transient erythroblastopenia of childhood. "
02/01/1995 - "The current state of knowledge concerning parvovirus enabled us to divide the long list of diseases caused by this virus into three main categories: (1) disease found among normal hosts (asymptomatic disease, erythema infectiosum, arthropathy, hydrops fetalis), (2) hematologic diseases (aplastic crisis, chronic anemia, idiopathic thrombocytopenic purpura, transient erythroblastopenia of childhood, Diamond-Blackfan anemia) and, finally, (3) a heterogeneous group of diseases, in which the etiologic role of parvovirus is less clear and sometimes putative (neurologic disease, rheumatologic disease, vasculitic and myocarditic syndromes). "
12/15/1992 - "We examined its effect in vitro on bone marrow and blood progenitors from patients with inherited bone marrow failure syndromes, including 17 patients each with Diamond-Blackfan anemia (DBA) and Fanconi's anemia (FA), 3 with dyskeratosis congenita (DC), and 1 each with amegakaryocytic thrombocytopenia (amega) and transient erythroblastopenia of childhood (TEC). "
3. Messenger RNA (mRNA)IBA
4. Prostaglandins D (PGD)IBA
5. Prednisone (Sone)FDA LinkGeneric
6. Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
7. hypohidrotic Ectodermal dysplasia with immune deficiencyIBA
8. Ribosomal Proteins (Ribosomal Protein)IBA
9. Shwachman syndromeIBA
10. Cyclosporine (Ciclosporin)FDA LinkGeneric

Therapies and Procedures

1. Transplantation (Transplant Recipients)
2. Hematopoietic Stem Cell Transplantation
3. Transplants (Transplant)
4. Stem Cell Transplantation
5. Bone Marrow Transplantation (Transplantation, Bone Marrow)