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Activin Receptors (Activin Receptor)

Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
Also Known As:
Activin Receptor; Activin Receptor-like Kinase; Receptor, Activin; Activin Receptor like Kinase; Activin Receptor like Kinases; Kinase, Activin Receptor-like; Kinases, Activin Receptor-like; Receptor-like Kinase, Activin; Receptor-like Kinases, Activin; Activin Receptor-Like Kinases
Networked: 225 relevant articles (6 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Oh, S Paul: 7 articles (10/2014 - 07/2007)
2. Young, William L: 7 articles (03/2014 - 02/2004)
3. Kim, Dae-Kee: 7 articles (11/2013 - 12/2008)
4. ten Dijke, Peter: 7 articles (01/2013 - 10/2004)
5. Su, Hua: 6 articles (03/2014 - 12/2008)
6. Peng, Chun: 6 articles (12/2012 - 10/2006)
7. Pardali, Evangelia: 5 articles (07/2012 - 08/2002)
8. Kaplan, Frederick S: 5 articles (09/2010 - 03/2008)
9. Shore, Eileen M: 5 articles (09/2010 - 03/2008)
10. Umesaki, Naohiko: 5 articles (01/2010 - 09/2003)

Related Diseases

1. Anemia
2. Hyperplasia
3. Neoplasms (Cancer)
4. Fibrosis (Cirrhosis)
5. Cicatrix (Scar)

Related Drugs and Biologics

1. 3- ((4- (6- methylpyridin- 2- yl)- 5- (quinolin- 6- yl)- 1H- imidazol- 2- yl)methyl)benzamide
2. Phosphotransferases (Kinase)
3. Transforming Growth Factors (Transforming Growth Factor)
4. Activins (Activin)
5. Inhibins (Inhibin)
6. activin A
7. Follistatin
8. inhibin beta A subunit
9. inhibin A
10. Transforming Growth Factor beta (TGF-beta)

Related Therapies and Procedures

1. Stents
2. Heterologous Transplantation (Xenotransplantation)
3. Hysterectomy