Dicarboxylic Acid Transporters

A family of organic anion transporters that specifically transport DICARBOXYLIC ACIDS such as alpha-ketoglutaric acid across cellular membranes.

Also Known As:

Dicarboxylate Carrier; Dicarboxylate Transport Protein; Dicarboxylate Transporter; Dicarboxylic Acid Transport Proteins; Dicarboxylate Binding Protein; Transporters, Dicarboxylic Acid; Dicarboxylate-Binding Protein

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        Dicarboxylic Acid Transporters: 7
        Arabidopsis At2g32040 protein
        Arabidopsis AtpOMT1 protein
        Arabidopsis DCT1 protein
        Arabidopsis DCT2 protein
        bacteria DcuA dicarboxylate transporter
        C elegans nac-1 protein
        C elegans nac-3 protein
        Drosophila Indy protein
        E coli DctA protein
        E coli dcuB protein
        E coli DcuC protein
        E coli KgtP protein
        human SLC13A2 protein
        human Slc25a10 protein
        human SLC25A21 protein
        mouse Slc13a2 protein
        mouse Slc13a5 protein
        mouse Slc25a10 protein
        mouse Slc25a21 protein
        Panicum miliaceum mitochondrial malate translocator
        rat Slc13a2 protein
        rat Slc22a24 protein
        rat sodium-dependent dicarboxylate transporter 2
        Rhodobacter capsulatus DctM protein
        Rhodobacter capsulatus DctP protein
        S cerevisiae ODC1 protein
        Sinorhizobium DCTB protein
        Sinorhizobium meliloti dctA protein
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        Dicarboxylic Acid Transporters: 7
        Arabidopsis At2g32040 protein
        Arabidopsis AtpOMT1 protein
        Arabidopsis DCT1 protein
        Arabidopsis DCT2 protein
        bacteria DcuA dicarboxylate transporter
        C elegans nac-1 protein
        C elegans nac-3 protein
        Drosophila Indy protein
        E coli DctA protein
        E coli dcuB protein
        E coli DcuC protein
        E coli KgtP protein
        human SLC13A2 protein
        human Slc25a10 protein
        human SLC25A21 protein
        mouse Slc13a2 protein
        mouse Slc13a5 protein
        mouse Slc25a10 protein
        mouse Slc25a21 protein
        Panicum miliaceum mitochondrial malate translocator
        rat Slc13a2 protein
        rat Slc22a24 protein
        rat sodium-dependent dicarboxylate transporter 2
        Rhodobacter capsulatus DctM protein
        Rhodobacter capsulatus DctP protein
        S cerevisiae ODC1 protein
        Sinorhizobium DCTB protein
        Sinorhizobium meliloti dctA protein

Experts

1.	Burns, Travis: 1 article (11/2021)
2.	Guo, Fuzheng: 1 article (11/2021)
3.	Hull, Vanessa: 1 article (11/2021)
4.	McDonough, Jennifer: 1 article (11/2021)
5.	Pleasure, David: 1 article (11/2021)
6.	Popovich, Brad: 1 article (11/2021)
7.	Sternbach, Sarah: 1 article (11/2021)
8.	Wang, Yan: 1 article (11/2021)
9.	Ghavami, Ghazaleh: 1 article (03/2015)
10.	Motamedian, Ehsan: 1 article (03/2015)

Related Diseases

1.	Acidosis 09/01/1979 - "Therefore, the low rates of ammoniagenesis and the failure to adapt to acidosis in the rabbit are best explained by factors influencing the dicarboxylate transporter." 09/01/1979 - "There was no effect of chronic metabolic acidosis on dicarboxylate transporter activity. " 01/23/2004 - "Renal tubular citrate transport is accomplished by electrogenic Na(+) coupled dicarboxylate transporter NaDC-1, a carrier subjected to regulation by acidosis. "
2.	Nephrolithiasis 03/01/2000 - "Urinary citrate, which inhibits calcium nephrolithiasis, is determined by proximal reabsorption via an apical dicarboxylate transporter. "
3.	Canavan Disease (Leukodystrophy, Spongiform) 11/01/2021 - "Ablating the Transporter Sodium-Dependent Dicarboxylate Transporter 3 Prevents Leukodystrophy in Canavan Disease Mice."
4.	Neoplasms (Cancer) 03/01/2015 - "Computational results introduced SLC25A10 gene, which encodes mitochondrial dicarboxylate transporter involved in exchanging of small metabolites across the mitochondrial membrane that may play key role in high growing capacity of sensitive and resistant cancer cells. "
5.	Insulin Resistance 02/11/2005 - "On the other hand, treatments that lead to a hyperpolarization of the mitochondrial membrane, such as overexpression of the mitochondrial dicarboxylate carrier result in increased ROS formation and decreased insulin sensitivity, even under normoglycemic conditions. "

Related Drugs and Biologics

1.	Citric Acid (Citrate)
2.	Succinate Dehydrogenase (Fumarate Reductase)
3.	Sodium
4.	Calcium