beta Karyopherins (Importin-beta)

Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.

Also Known As:

Networked: 19 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Li, Xin: 2 articles (01/2020 - 01/2019)
2.	Angelini, Corrado: 1 article (01/2022)
3.	Cenacchi, Giovanna: 1 article (01/2022)
4.	Costa, Roberta: 1 article (01/2022)
5.	Pacilio, Serafina: 1 article (01/2022)
6.	Rodia, Maria Teresa: 1 article (01/2022)
7.	Birrer, Michael J: 1 article (02/2021)
8.	Chi, Ru-Pin Alicia: 1 article (02/2021)
9.	Leaner, Virna D: 1 article (02/2021)
10.	Wei, Wei: 1 article (02/2021)

Related Diseases

1.	Virus Diseases (Viral Diseases) 03/01/2007 - "To establish viral infection, SV40 must expose nuclear localization signals (NLSs) that are internal in the virion architecture in order to enter the nucleus via interaction with the host's nuclear import machinery, which includes importin alpha and importin beta. " 01/01/2022 - "TNPO3 encodes for transportin-3, which belongs to the importin beta family and transports into the nucleus serine/arginine-rich (SR) proteins, such as splicing factors, and HIV-1 proteins, thus contributing to viral infection. "
2.	Neoplasms (Cancer) 02/02/2021 - "Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. " 01/01/2022 - "Karyopherin alpha 2 (KPNA2) and karyopherin beta 1 (KPNB1) constitute nuclear transport protein complexes involved in nuclear import and are significant in tumor progression. "
3.	Infections 01/15/1998 - "Our data suggest Vpr functionally resembles importin-beta in nuclear import of the HIV-1 pre-integration complex and this function is essential for the role of Vpr in macrophage infection, but not G2 arrest." 03/01/2007 - "The viral DNA associated with importin alpha by 1.5h post infection, before associating with the importin beta nuclear import receptor, by 3h post infection. "
4.	Carcinogenesis 03/07/2015 - "Previously, we demonstrated that the EZH2/miR-30d/karyopherin (importin) beta 1 (KPNB1) signaling pathway is critical for malignant peripheral nerve sheath tumor (MPNST) cell survival in vitro and for tumorigenesis in vivo. "
5.	Sepsis (Septicemia) 01/01/2017 - "We studied the impact of simultaneously targeting two of these shuttles, importin alpha 5 (Imp α5) and importin beta 1 (Imp β1), with a cell-penetrating Nuclear Transport Modifier (NTM) in a mouse model of polymicrobial sepsis. "

Related Drugs and Biologics

1.	alpha Karyopherins
2.	Proteins (Proteins, Gene)
3.	Karyopherins (Importin)
4.	Nuclear Localization Signals (Nuclear Localization Signal)
5.	Arginine (L-Arginine)
6.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
7.	Parathyroid Hormone-Related Protein
8.	Ubiquitin
9.	Small Nuclear Ribonucleoproteins (snRNP)
10.	rex Gene Products