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alpha Karyopherins

Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Also Known As:
Importin-alpha; Karyopherin alpha; NLS Receptor; NLS-Binding Protein; NLSBP; Nuclear Localization Sequence Receptor; Nuclear Localization Signal-Binding Protein; Karyopherins, alpha; receptor, NLS
Networked: 33 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jans, David A: 4 articles (06/2010 - 01/2002)
2. Yoneda, Yoshihiro: 3 articles (06/2004 - 05/2004)
3. Depping, Reinhard: 2 articles (09/2010 - 03/2008)
4. Fagerlund, Riku: 2 articles (08/2008 - 03/2008)
5. Vasudevan, Subhash G: 2 articles (07/2007 - 09/2002)
6. Hiraoka, Yasushi: 2 articles (06/2004 - 05/2004)
7. Haraguchi, Tokuko: 2 articles (06/2004 - 05/2004)
8. Katagiri, Toyomasa: 1 article (01/2015)
9. Komatsu, Masato: 1 article (01/2015)
10. Mizuguchi, Kenji: 1 article (01/2015)

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Related Drugs and Biologics

1. Small Interfering RNA (siRNA)
2. Antibodies
3. beta Karyopherins (Importin-beta)
4. Nuclear Localization Signals (Nuclear Localization Signal)
5. Proteins (Proteins, Gene)
6. Karyopherins (Importin)
7. Phosphotransferases (Kinase)
8. Amino Acids
9. karyopherin alpha 2
10. Parathyroid Hormone-Related Protein