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Familial Cerebral Amyloid Angiopathy

A familial disorder marked by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES.
Also Known As:
Cerebral Amyloid Angiopathy, Familial; Amyloidosis VI; Amyloidosis, Cerebroarterial, Icelandic Type; Autosomal Dominant Cerebrovascular Amyloidosis; Cerebral Amyloid Angiopathy, Cst3-Related; Cerebral Amyloid Angiopathy, Genetic; Cerebral Amyloid Angiopathy, Hereditary; Cerebral Hemorrhage, Hereditary, With Amyloidosis; HCHWA; Hereditary Cerebral Amyloid Angiopathy; Hereditary Cerebral Amyloid Angiopathy, Icelandic Type; Hereditary Cerebral Hemorrhage With Amyloidosis; Icelandic Type Amyloidosis; Icelandic Type Hereditary Cerebral Amyloid Angiopathy; Amyloidosis VIs; Amyloidosis, Icelandic Type; Cerebral Amyloid Angiopathy, Cst3 Related
Networked: 190 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Cerebral Amyloid Angiopathy (Congophilic Angiopathy)
3. Down Syndrome (Down's Syndrome)
4. Amyloid angiopathy
5. Hemorrhage

Experts

1. Greenberg, Steven M: 9 articles (04/2020 - 07/2008)
2. van Buchem, Mark A: 9 articles (01/2018 - 09/2009)
3. van Duinen, Sjoerd G: 9 articles (01/2018 - 05/2004)
4. Verbeek, Marcel M: 8 articles (01/2017 - 10/2002)
5. de Waal, Robert M W: 7 articles (04/2010 - 10/2002)
6. van der Weerd, Louise: 6 articles (01/2020 - 12/2009)
7. van Rooden, Sanneke: 6 articles (01/2018 - 09/2009)
8. van der Grond, Jeroen: 6 articles (02/2017 - 09/2009)
9. Wilhelmus, Micha M M: 6 articles (04/2013 - 02/2006)
10. Maat-Schieman, Marion L C: 6 articles (12/2009 - 05/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial Cerebral Amyloid Angiopathy:
1. Amyloid beta-PeptidesIBA
2. Peptides (Polypeptides)IBA
3. AntibodiesIBA
05/01/2004 - "To evaluate whether clearance of Abeta by glial cells may play a role in this regard, this immunohistochemical study of frontal cortex of 14 HCHWA-D autopsy brains was performed using double staining with glial markers and end-specific antibodies to Abetax-42 (Abeta42) and Abetax-40 (Abeta40). "
01/01/1993 - "Since a central issue in the pathophysiology of Alzheimer's disease and related conditions is the role of A beta in the neurodegenerative process, we investigated HCHWA-D brains for the presence of neuritic abnormalities using antibodies to ubiquitin and to phosphorylated neurofilaments. "
07/01/1990 - "Brain tissue from 11 patients with cerebral amyloid angiopathy, changes of Alzheimer's disease, and variable degrees of subcortical leukoencephalopathy was examined by immunohistochemical methods, using primary antibodies to peptide segments representing portions of the Alzheimer A4 (beta-) peptide or gamma-trace peptide (seen most commonly in Icelandic patients with cerebral hemorrhage (hereditary cerebral hemorrhage with amyloidosis [HCHWA-I]). "
01/01/1989 - "alpha 1-antichymotrypsin antibodies immunolabeled only amyloid deposits that have as their major component the beta-protein: normal aging, Alzheimer's disease, Down's syndrome and in the hereditary cerebral hemorrhage with amyloidosis of Dutch origin (HCHWA-D), but not in Creutzfeldt-Jakob disease, Familial Amyloidotic Neuropathy, primary amyloidosis, or secondary amyloidosis. "
01/01/1992 - "Immunohistochemical studies were performed on biopsy specimens using primary antibodies against portions of the Alzheimer A4 (beta-) peptide or gamma-trace peptide (the vascular amyloid protein in patients with hereditary cerebral hemorrhage with amyloidosis-Icelandic type). "
4. Cathepsin DIBA
5. Amyloid (Amyloid Fibrils)IBA
6. Proteins (Proteins, Gene)FDA Link
7. Amyloidogenic ProteinsIBA
8. Cystatin CIBA
9. Codon (Codons)IBA
10. Formaldehyde (Formol)FDA Link