HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Organic Cation Transporter 1

An organic cation transporter found in kidney. It is localized to the basal lateral membrane and is likely to be involved in the renal secretion of organic cations.
Also Known As:
OCT1 Protein; OCT1 Transport Protein; SLC22A1 Transporter; Solute Carrier Family 22 (Organic Cation Transporter), Member 1; Protein, OCT1 Transport; Transport Protein, OCT1; Transporter, SLC22A1
Networked: 38 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Koepsell, Hermann: 3 articles (02/2014 - 05/2004)
2. Becker, M L: 2 articles (06/2015 - 08/2009)
3. van Schaik, R H N: 2 articles (06/2015 - 08/2009)
4. Fardel, Olivier: 2 articles (03/2014 - 08/2011)
5. Jouan, Elodie: 2 articles (03/2014 - 08/2011)
6. Le Vee, Marc: 2 articles (03/2014 - 08/2011)
7. Sparreboom, Alex: 2 articles (02/2014 - 05/2008)
8. Hu, Shuiying: 2 articles (02/2014 - 05/2008)
9. Baker, Sharyn D: 2 articles (02/2014 - 05/2008)
10. Clark, Richard E: 2 articles (10/2012 - 10/2008)

Related Diseases

1. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
2. Crohn Disease (Crohn's Disease)
3. Prostatic Neoplasms (Prostate Cancer)
4. Breast Neoplasms (Breast Cancer)
04/01/2008 - "Specifically, we focused on the efflux transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), and an influx transporter, organic cation transporter 1 (OCT1). "
05/01/2015 - "Other renal transporters (human organic anion-transporting polypeptide 4C1 [OATP4C1], organic cation transporter 2 [OCT2], carnitine/organic cation transporter 1 [OCTN1], multidrug and toxin extrusion protein 1 [MATE1], MATE2-K, multidrug resistance-associated protein 2 [MRP2], MRP4, and breast cancer resistance protein [BCRP], and rat Oct1, Oct2, Octn1, Octn2, Mate1, Mrp2, Mrp4, and Bcrp) showed either ambiguous ability to transport tanshinol or no transport activity. "
01/01/2015 - "We investigated the in vitro transport characteristics of catalposide in HEK293 cells overexpressing organic anion transporter 1 (OAT1), OAT3, organic anion transporting polypeptide 1B1 (OATP1B1), OATP1B3, organic cation transporter 1 (OCT1), OCT2, P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP). "
07/15/2009 - "We investigated the impact of 16 single nucleotide polymorphisms (SNP) in five genes potentially associated with pharmacogenetics of IM, namely ABCB1, multidrug resistance 1; ABCG2, breast-cancer resistance protein; CYP3A5, cytochrome P450-3A5; SLC22A1, human organic cation transporter 1; and AGP, alpha1-acid glycoprotein. "
04/01/2008 - "Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells."
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. imatinib (Gleevec)
2. Metformin (Glucophage)
3. P-Glycoprotein
4. Messenger RNA (mRNA)
5. Taurocholic Acid (Sodium Taurocholate)
6. multidrug resistance-associated protein 2
7. Carboxylesterase (Hydrolase S)
8. Cytochrome P-450 CYP1A2 (CYP1A2)
9. Paclitaxel (Taxol)
10. Cytokines

Related Therapies and Procedures

1. Castration