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Multidrug Resistance-Associated Proteins

A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
Also Known As:
ATP-Binding Cassette, Sub-Family C Proteins; MOAT Protein; Multispecific Organic Anion Transport Proteins; Multispecific Organic Anion Transporter; ATP Binding Cassette, Sub Family C Proteins; Multidrug Resistance Associated Protein; Multidrug Resistance Associated Proteins; Resistance-Associated Protein, Multidrug; Multidrug Resistance-Associated Protein
Networked: 537 relevant articles (6 outcomes, 60 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Scheffer, George L: 10 articles (04/2012 - 12/2002)
2. Aleksunes, Lauren M: 9 articles (12/2012 - 02/2006)
3. Sugiyama, Yuichi: 7 articles (11/2013 - 01/2007)
4. Kusuhara, Hiroyuki: 6 articles (11/2013 - 01/2007)
5. Yokooji, Tomoharu: 5 articles (01/2013 - 04/2007)
6. Klaassen, Curtis D: 5 articles (01/2012 - 05/2006)
7. Manautou, José E: 5 articles (09/2008 - 02/2006)
8. Stieger, Bruno: 4 articles (04/2014 - 03/2006)
9. Bendayan, Reina: 4 articles (09/2013 - 12/2008)
10. Scheper, Rik J: 4 articles (04/2012 - 12/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Drug Toxicity (Drug Safety)
4. Rheumatoid Arthritis
5. Lung Neoplasms (Lung Cancer)

Related Drugs and Biologics

1. P-Glycoprotein
2. major vault protein
3. Proteins (Proteins, Gene)
4. Adenosine Triphosphate (ATP)
5. Glutathione S-Transferase pi
6. Enzymes
7. Metallothionein
8. Proteasome Endopeptidase Complex (Proteasome)
9. Cytochromes
10. Retinoblastoma Protein

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Adjuvant Chemotherapy
3. Microspheres (Microsphere)
4. Heterologous Transplantation (Xenotransplantation)
5. Mastectomy (Mammectomy)