|1.||Scheffer, George L: 10 articles (04/2012 - 12/2002)|
|2.||Aleksunes, Lauren M: 9 articles (12/2012 - 02/2006)|
|3.||Sugiyama, Yuichi: 7 articles (11/2013 - 01/2007)|
|4.||Kusuhara, Hiroyuki: 6 articles (11/2013 - 01/2007)|
|5.||Yokooji, Tomoharu: 5 articles (01/2013 - 04/2007)|
|6.||Klaassen, Curtis D: 5 articles (01/2012 - 05/2006)|
|7.||Manautou, José E: 5 articles (09/2008 - 02/2006)|
|8.||Stieger, Bruno: 4 articles (04/2014 - 03/2006)|
|9.||Bendayan, Reina: 4 articles (09/2013 - 12/2008)|
|10.||Scheper, Rik J: 4 articles (04/2012 - 12/2002)|
04/01/2006 - "The present study aims to provide an update of multidrug resistance in tumor cells and, in particular, of multidrug resistance-associated proteins."
10/27/2004 - "Studies focusing on the transcriptional regulation of MRP7 (multidrug resistance associated protein 7) gene expression in human tumor cells are described. "
11/01/2013 - "The expression of a multispecific organic anion transporter, OATP1B3/SLCO1B3, is associated with clinical prognosis and survival of cancer cells. "
04/01/2013 - "Technetium-99m sestamibi ((99m)Tc-MIBI) scintigraphy has been reported to be a functional imaging tool for in vivo detection of mitochondrial dysfunction in myocardium and multidrug resistance-associated protein expression in tumors. "
01/01/2013 - "Overexpression of multidrug resistance-associated proteins (MRPs) in tumor cells is a major cause of the intrinsic multidrug resistance phenotype. "
|2.||Breast Neoplasms (Breast Cancer)
10/01/2011 - "Recent in vitro studies demonstrated that EEG is transported by multidrug resistance-associated protein (MRP) 2 and MRP3 and EES is a breast cancer resistance protein (BCRP) substrate. "
05/01/2010 - "Further studies in pharmacogenetics and in vitro models to assess statin disposition and toxicity are required to understand the contribution of others transporters, such as multidrug resistance-associated protein (MRP)1, MRP2, breast cancer resistance protein, OATP2B1, OAT1B3 and OATP1A2, in interindividual variability to statins efficacy and safety."
02/01/2014 - "However, bile salt export pump, Abcb1b, multidrug resistance-associated protein, and breast cancer resistance protein transporters were functional in B-13/H cells. "
09/01/2013 - "The same trend was observed for the substrates of organic cation transporter 2, multidrug and toxin extrusion, multidrug resistance-associated protein 4, and multidrug resistance 1/breast cancer resistance protein, but substantial fractions of the substrates were categorized as the intermediate or reabsorption types (9%-38%). "
09/08/2012 - "The SNaPshot SNP technique was used to analyze single-nucleotide polymorphisms (SNPs) in the multidrug transporter 1 (MDR1), multidrug resistance associated proteins (MRP1, MRP2) and breast cancer resistance protein (BCRP) genes of 82 pediatric ALL patients. "
|3.||Drug Toxicity (Drug Safety)
12/01/1998 - "Major research challenges include the following: (1) the genetic variation of drug targets (receptors, enzymes, etc.), drug transporters (multispecific organic anion transporter, P-glycoprotein, alpha-1-acid glycoprotein, etc.), and drug-metabolizing enzymes (cytochrome P450s and other enzymes); (2) the structure and function of all genetic variants of drug receptors, transporters, and metabolizing enzymes; (3) the induction, repression, and inhibition of all components involved in drug disposition; (4) the development of noninvasive in vivo methods to determine the physiological significance of various components in the handling of specific therapeutic agents in humans; (5) the mechanism of idiosyncratic adverse drug reactions; and (6) the pharmacokinetic and pharmacodynamic relationships to explain the individual differences in therapeutic efficacy and drug safety. "
|5.||Lung Neoplasms (Lung Cancer)
09/01/2008 - "To explore the effect of supplement energy and nourish lung (SENL) herbs on the growth of drug-resistance lung cancer cells, expression of multidrug resistance-associated protein (MRP) and mechanisms of mitochondrial and Caspase signal. "
11/01/2001 - "Human lung cancer cells whose multidrug resistance (MDR) counterparts over-express the multidrug resistance-associated protein MRP1 have not yet been studied by NMR. "
09/26/1997 - "The multidrug resistance-associated protein (MRP), mediating a multidrug resistance (MDR) phenotype, has been reported to be overexpressed in several drug-selected lung cancer cell lines. "
09/01/1997 - "Multidrug resistance-associated protein gene expression and drug sensitivity in human lung cancer cells."
01/01/1997 - "The multidrug resistance-associated protein (MRP) gene is thought to play an important role in MDR in lung cancer. "
|2.||major vault protein
|3.||Proteins (Proteins, Gene)
|4.||Adenosine Triphosphate (ATP)
|5.||Glutathione S-Transferase pi
|8.||Proteasome Endopeptidase Complex (Proteasome)
|1.||Drug Therapy (Chemotherapy)
|4.||Heterologous Transplantation (Xenotransplantation)