|1.||You, Guofeng: 7 articles (01/2012 - 07/2004)|
|2.||Gartung, Carsten: 6 articles (11/2005 - 06/2002)|
|3.||Geier, Andreas: 6 articles (11/2005 - 06/2002)|
|4.||Dietrich, Christoph G: 6 articles (11/2005 - 06/2002)|
|5.||Matern, Siegfried: 6 articles (11/2005 - 06/2002)|
|6.||Stieger, Bruno: 5 articles (04/2014 - 08/2002)|
|7.||Brandoni, Anabel: 4 articles (11/2012 - 05/2006)|
|8.||Torres, Adriana M: 4 articles (01/2010 - 05/2006)|
|9.||Zhou, Fanfan: 4 articles (07/2007 - 07/2004)|
|10.||Lammert, Frank: 4 articles (11/2005 - 06/2002)|
06/01/2015 - "Collectively, these data show that maternal infections impact the expression of key drug transporters in placenta, suggesting that materno-fetal drug transport may be altered by changes in placental expression of ABC and OATP transporters."
01/01/2013 - "Probenecid, a prototypical uricosuric agent and chemical inhibitor of organic anion transporters known to target OAT3, was shown to be effective in limiting influenza A virus infection in vitro (50% inhibitory concentration [IC(50)] of 5.0 × 10(-5) to 5.0 × 10(-4) μM; P < 0.005) and in vivo (P < 0.05). "
|2.||Breast Neoplasms (Breast Cancer)
06/01/2007 - "Additional studies have shown that efflux transporters, such as multi-drug resistance-associated protein 2, breast cancer-resistant protein and the organic anion transporters, appear to serve as the gate keeper when there is an excess capacity to metabolise the compounds. "
03/01/2014 - "These transporters include members belonging to the organic cation/anion/zwitterion solute carrier family, such as the organic anion transporters (OAT)1, OAT3, and OATP4C1, and to the adenosine triphosphate binding cassette superfamily of transmembrane transporters, including the multidrug resistance proteins and breast cancer resistance protein. "
01/01/2012 - "Protein and mRNA expression of influx transporters [organic anion-transporting polypeptide (Oatp), organic anion transporter (Oat)] and efflux transporters [P-glycoprotein (P-gp), multidrug resistance-related protein (Mrp), breast cancer resistance protein (Bcrp)] were measured in CRF and control rat brain. "
02/01/2008 - "Other transporters such as the influx transporters organic anion transporting polypeptide (OATP)-B, OATP-C, and OATP8 and the efflux pumps multidrug resistance-associated protein (MRP) 2, MRP3, MRP4, and breast cancer resistance protein were also down-regulated at mRNA levels in human hepatocytes treated by IL-1beta for 24 h, and most of these transporters were similarly repressed in IL-1beta-exposed HepaRG cells; the cytokine also reduced bile salt export pump (BSEP) and OATP-C protein expression in human hepatocytes. "
11/01/2006 - "Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats."
11/21/2008 - "Time elapsed after obstructive cholestasis has an important impact on the regulation of both types of organic anion transporters. "
01/10/2003 - "Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat."
06/01/2002 - "Since down-regulation of hepatocellular organic anion transporters is implicated in the molecular pathogenesis of cholestasis, expression of these transporters was determined in a novel rat model, which closely resembles human PSC. "
12/01/1999 - "To study the molecular mechanisms leading to cholestasis, expression of all major hepatic organic anion transporters contributing to bile formation was determined for up to 2 weeks in rats after 70% partial hepatectomy. "
08/01/2002 - "Acute liver injury results in down-regulation of basolateral organic anion transporters similar to liver regeneration after partial hepatectomy, but in contrast to endotoxin-induced cholestasis. "
09/01/2003 - "Finally, we hypothesize here that organic anion transporters might impact renal susceptibility to ischemia and toxic injury, because their uptake of substrates can result in the efflux of Krebs cycle intermediates, an important nutrient source for the proximal tubule. "
03/01/2007 - "The effect of acute renal failure (ARF) induced by ischemia/reperfusion (I/R) of rat kidney on the expression of organic anion transporters (OATs) was examined. "
03/01/2007 - "Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute [corrected] renal failure."
01/01/2008 - "This study was undertaken to evaluate the cortical renal blood flow (cRBF) and the renal protein expression of the organic anion transporters (OAT1 and OAT3) in association with the elimination of organic anions in an early stage of renal ischemia-reperfusion. "
02/01/2015 - "Expression of proximal tubular organic anion transporters Oat1 and Oat3 is reduced by PGE2 after renal ischemia and reperfusion (I/R) injury. "
|5.||Hepatocellular Carcinoma (Hepatoma)
02/01/2008 - "Therefore, the present study was aimed at determining IL-1beta effects on expression of organic anion transporters in primary human hepatocytes and highly differentiated human hepatoma HepaRG cells. "
04/01/2003 - "Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma."
|6.||p-Aminohippuric Acid (p-Aminohippurate)
|7.||Hypoglycemic Agents (Hypoglycemics)
|8.||lenalidomide (CC 5013)
|9.||Antihypertensive Agents (Antihypertensives)
|10.||Anti-Bacterial Agents (Antibiotics)
|3.||Drug Therapy (Chemotherapy)