|1.||Hermans, Emmanuel: 8 articles (01/2015 - 07/2002)|
|2.||Robinson, Michael B: 8 articles (07/2014 - 03/2002)|
|3.||Rothstein, Jeffrey D: 8 articles (10/2013 - 02/2002)|
|4.||Tanaka, Kohichi: 6 articles (01/2013 - 08/2003)|
|5.||Sontheimer, Harald: 5 articles (01/2015 - 04/2010)|
|6.||Meador-Woodruff, James H: 5 articles (03/2013 - 06/2005)|
|7.||McCullumsmith, Robert E: 5 articles (03/2013 - 06/2005)|
|8.||Engele, Jürgen: 5 articles (01/2012 - 09/2003)|
|9.||Maragakis, Nicholas J: 5 articles (12/2011 - 02/2002)|
|10.||Rothstein, J D: 5 articles (01/2009 - 05/2000)|
01/01/2005 - "Recent studies demonstrated that spinal glutamate transporter inhibition relieved pathological pain, suggesting that the spinal glutamate transporter might serve as a therapeutic target for treatment of pathological pain. "
01/01/2013 - "Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens."
01/01/2012 - "Glutamate transporter dysfunction associated with nerve injury-induced pain in mice."
11/04/2010 - "Here, we demonstrate that deletion of vesicular glutamate transporter (VGLUT) 2 in a subpopulation of neurons partly overlapping with the vanilloid receptor (TRPV1) primary afferents resulted in a dramatic increase in itch behavior accompanied by a reduced responsiveness to thermal pain. "
10/16/2006 - "Recent evidence suggests that glutamate transporter down-regulation follows repeated opiate exposure and contributes to heightened pain sensitivity. "
|2.||Alzheimer Disease (Alzheimer's Disease)
02/01/2002 - "This study implicates aberrant glutamate transporter expression as a mechanism involved in neurodegeneration in Alzheimer's disease."
03/09/2015 - "Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease."
03/20/2013 - "These findings indicate that astrocytic glutamate transporter dysfunction may play an important role in the pathogenesis of Alzheimer's disease and suggest possible mechanisms by which several current treatment strategies could protect against the disease."
01/01/2011 - "GLT-1, the dominant glutamate transporter in the cerebral cortex and hippocampus, is significantly reduced in Alzheimer's disease (AD). "
08/01/1997 - "Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression."
10/01/2013 - "The authors therefore hypothesized that the protective mechanism of glutamate transporter upregulation would be useful for the treatment of gliomas as well. "
10/01/2013 - "It suggests that glutamate transporter upregulation for the treatment of gliomas should be further investigated and potentially be part of a combination therapy with standard chemotherapeutic agents."
10/15/2011 - "Pearson correlation coefficient analysis in normal brain tissues and samples from glioma patients indicated a strong negative correlation between expression of AEG-1 and a primary glutamate transporter of astrocytes EAAT2. "
07/01/2009 - "Enhanced expression of the high affinity glutamate transporter GLT-1 in C6 glioma cells delays tumour progression in rat."
02/24/2006 - "Here we show that PDGF had no effect on subcellular localization of the glial glutamate transporter, GLT-1, after transfection into C6 glioma cells. "
10/18/2011 - "However, these studies have produced conflicting results and the changes in glutamate transporter expression have not yet been examined in a mouse focal ischemic stroke model. "
11/16/2010 - "Vesicular glutamate transporter and cognition in stroke: a case-control autopsy study."
01/01/2016 - "Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke."
01/01/2011 - "The aim of this study was to examine if overexpression of a glutamate transporter (GLT-1) reduces ischemic brain injury in a rat model of stroke. "
01/01/2011 - "Targeted over-expression of glutamate transporter 1 (GLT-1) reduces ischemic brain injury in a rat model of stroke."
|5.||Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
06/01/1995 - "Studies of the coding region of the neuronal glutamate transporter of 6 amyotrophic lateral sclerosis (ALS) patients and 10 controls show an identical pattern of four reported amino acid variations. "
06/01/1995 - "Studies of the coding region of the neuronal glutamate transporter gene in amyotrophic lateral sclerosis."
01/01/2014 - "Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-α in cortical astrocytes from a rat model of amyotrophic lateral sclerosis."
10/15/2004 - "Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS)."
02/01/2004 - "On the other hand, upregulation of the glial glutamate transporter GLT1 (SLC1A2) may help protect motor neurons in patients with amyotrophic lateral sclerosis (ALS), since loss of function of GLT1 has been associated with the pathogenesis of certain forms of ALS."
|1.||Glutamic Acid (Glutamate)
|4.||Messenger RNA (mRNA)
|5.||Amino Acid Transport System X-AG (Glutamate Transporter)
|6.||Excitatory Amino Acids
|7.||Proteins (Proteins, Gene)
|9.||Morphine (MS Contin)
|10.||Glial Fibrillary Acidic Protein
|5.||Surgical Portacaval Shunt (Portacaval Anastomosis)