Heavy Chain Fusion Regulatory Protein 1

A transmembrane glycoprotein subunit that can dimerize with a variety of light chain subunits such as SLC7A5; SLC7A6, and 4F2 LIGHT CHAINS. This protein subunit serves a diverse array of functions including amino acid transport and cell fusion. Its function is altered depending which of the light chain subunits it interacts with.

Also Known As:

Networked: 22 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kanai, Yoshikatsu: 6 articles (09/2010 - 05/2004)
2.	Hisada, Takeshi: 4 articles (09/2010 - 02/2009)
3.	Imai, Hisao: 4 articles (09/2010 - 02/2009)
4.	Ishizuka, Tamotsu: 4 articles (09/2010 - 02/2009)
5.	Kaira, Kyoichi: 4 articles (09/2010 - 02/2009)
6.	Mori, Masatomo: 4 articles (09/2010 - 02/2009)
7.	Nakajima, Takashi: 4 articles (09/2010 - 02/2009)
8.	Oriuchi, Noboru: 4 articles (09/2010 - 02/2009)
9.	Shimizu, Kimihiro: 4 articles (09/2010 - 02/2009)
10.	Sunaga, Noriaki: 4 articles (09/2010 - 02/2009)

Related Diseases

1.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/01/2009 - "The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT 1) and 4F2 heavy chain (CD98) in patients with stage I squamous cell carcinoma of the lung. " 02/01/2009 - "Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung." 10/22/2022 - "In this study, we analyzed SLC3A2 mRNA levels in human lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) using the TCGA database and serum SLC3A2 protein levels using ELISA. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/01/2010 - "The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in patients with stage III non-small cell lung cancer (NSCLC). " 12/01/2009 - "The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in resectable non-small-cell lung cancer (NSCLC) patients with N1 and N2 nodal involvement. " 09/01/2010 - "Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in surgically resectable stage III non-small cell lung cancer."
3.	Carcinogenesis 02/01/2008 - "To study the expression and function of L-type amino acid transporter 1 (LAT1), a major catalytic subunit of system L that is responsible for the transport of large neutral amino acids, including most essential amino acids, in concert with the covalently bound 4F2 heavy chain, and is implicated in tumorigenesis. "
4.	Neuroblastoma 01/01/2019 - "In this study, we identified solute carrier family 3 member 2 (SLC3A2) as the key transporter involved in polyamine uptake in neuroblastoma. " 01/01/2019 - "Knockdown of SLC3A2 in neuroblastoma cells reduced the uptake of the radiolabeled polyamine spermidine, and DFMO treatment increased SLC3A2 protein. "
5.	Lung Neoplasms (Lung Cancer) 06/01/2023 - "In the present study, we revealed that high solute carrier family 3 member 2 (SLC3A2) expression in lung cancer patients was associated with TAMs and poor prognosis. "

Related Drugs and Biologics

1.	Amino Acid Transport Systems (Amino Acid Transporter)
2.	Messenger RNA (mRNA)
3.	Essential Amino Acids
4.	Neutral Amino Acids
5.	Polyamines
6.	Proteins (Proteins, Gene)
7.	Glutathione (Reduced Glutathione)
8.	Phospholipid Hydroperoxide Glutathione Peroxidase
9.	TOR Serine-Threonine Kinases
10.	Endosomal Sorting Complexes Required for Transport

Related Therapies and Procedures

1.	Chemoradiotherapy