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DNA Gyrase

A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting two A and two B subunits. In the presence of ATP, gyrase is able to convert relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
Also Known As:
DNA-Gyrase; gyrA Gene product; gyrB Gene Product; DNA Gyrase A Subunit; DNA Gyrase B Subunit; gyrA Protein; gyrB Protein
Networked: 75 relevant articles (2 outcomes, 3 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Aubry, Alexandra: 10 articles (11/2013 - 04/2004)
2. Mayer, Claudine: 6 articles (08/2014 - 01/2010)
3. Sriram, Dharmarajan: 5 articles (03/2015 - 06/2006)
4. Cambau, Emmanuelle: 5 articles (04/2012 - 04/2004)
5. Yogeeswari, Perumal: 4 articles (03/2015 - 06/2006)
6. Jarlier, Vincent: 4 articles (02/2013 - 04/2004)
7. Nagaraja, Valakunja: 4 articles (03/2008 - 01/2005)
8. Madhavapeddi, Prashanti: 3 articles (02/2015 - 01/2014)
9. Maxwell, Anthony: 3 articles (03/2014 - 01/2005)
10. Piton, Jérémie: 3 articles (11/2013 - 01/2010)

Related Diseases

1. Tuberculosis (Tuberculoses)
2. Bacterial Infections (Bacterial Infection)
3. Infection
4. Shock
5. Hypersensitivity (Allergy)

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. Ciprofloxacin (Cipro)
3. DNA Topoisomerase IV (Topoisomerase IV)
4. DNA Topoisomerases
5. Ofloxacin (Levofloxacin)
6. Chlorhexidine
7. Bacterial Proteins (Bacterial Protein)
8. cethromycin
9. Fluoroquinolones
10. Novobiocin (Streptonivicin)