DNA Topoisomerases

Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.

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Networked: 100 relevant articles (5 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nitiss, John L: 4 articles (10/2021 - 10/2002)
2.	Balaña-Fouce, Rafael: 3 articles (12/2014 - 06/2009)
3.	Reguera, Rosa M: 3 articles (12/2014 - 06/2009)
4.	Austin, Caroline A: 3 articles (02/2010 - 01/2006)
5.	Ivanova, L V: 3 articles (01/2003 - 10/2000)
6.	Proppe, D: 3 articles (01/2003 - 10/2000)
7.	Rudolph, P: 3 articles (01/2003 - 10/2000)
8.	Zhang, Qi: 2 articles (01/2022 - 12/2021)
9.	Débat, Hélène: 2 articles (01/2021 - 01/2018)
10.	Garnier, Florence: 2 articles (01/2021 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 08/01/1994 - "Drugs that interact with DNA topoisomerases I and II hold great promise for the treatment of cancer, however, like many other anti-cancer agents, they are a double-edged sword and may themselves cause mutation and cancer. " 12/01/2021 - "DNA topoisomerases are proved cancer therapeutic targets with clinically successful anticancer drugs for decades. " 10/01/2021 - "DNA topoisomerases are important targets of approved and experimental anti-cancer agents. " 11/10/2015 - "DNA topoisomerases play a key role in tumor proliferation. " 06/01/2012 - "DNA topoisomerases are important targets of approved and experimental anti-cancer agents. "
2.	Communicable Diseases (Infectious Diseases) 03/01/2007 - "These new developments of DNA topoisomerases as targets of novel therapeutic agents being reviewed here represent excellent opportunities for drug discovery in the treatment of infectious diseases." 03/01/2007 - "Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases." 09/01/1997 - "Chemical agents able to interfere with DNA topoisomerases are widespread in nature, and some of them have outstanding therapeutic efficacy in human cancer and infectious diseases. " 11/01/2001 - "Chemical agents able to interfere with DNA topoisomerases - essential nuclear enzymes- are widespread in nature, and some of them have outstanding therapeutic efficacy in human cancer and infectious diseases. "
3.	Bacterial Infections (Bacterial Infection) 01/01/2020 - "Fluoroquinolones are a class of antibacterial agents used clinically to treat a wide array of bacterial infections and target bacterial type-II topoisomerases (DNA gyrase and topoisomerase IV). " 06/01/2010 - "The fluorinated quinolone, ciprofloxacin, is an antibiotic effective for treating bacterial infections by inhibiting the enzyme activity of the DNA type II topoisomerases DNA gyrase and topoisomerase IV. The genes that encode the subunits of DNA gyrase (gyrA and gyrB) and topo IV (par C and parE) contain hotspots within an area known as the quinolone resistance-determining region (QRDR). "
4.	Leukemia 07/31/1985 - "We have undertaken a study of DNA topoisomerases in mitochondria from human acute leukemia cells. " 10/01/1994 - "Involvement of DNA topoisomerases and DNA topoisomerase inhibitors in the induction of leukemia cell differentiation." 04/01/2010 - "Albanol A (1), isolated from the root bark extract of Morus alba (mulberry), was evaluated for the cytotoxic and apoptosis-inducing activities in human leukemia (HL60) cells, and for the inhibitory activity in human DNA topoisomerases (Topo) I and II. This compound showed potent cytotoxic activity (IC(50) 1.7 microM) on the cells, and potent inhibitory activity on topoisomerase II (IC(50) 22.8 microM). " 06/01/1997 - "The proteins and enzymatic activities thus far identified to co-purify with the leukemia cell DNA synthesome include the DNA polymerases alpha and delta, DNA primase, proliferating cell nuclear antigen (PCNA), replication factor C (RF-C), replication protein A (RP-A), and DNA topoisomerases I and II. We have demonstrated that the DNA synthesome is fully competent to replicate simian virus 40 (SV40) replication origin containing DNA in vitro in the presence of the viral large T-antigen. "
5.	Leishmaniasis 11/23/2023 - "DNA topoisomerases as a drug target in Leishmaniasis: Structural and mechanistic insights." 10/01/2012 - "DNA topoisomerases (Top) have been identified as promising targets for therapy against leishmaniasis. " 09/05/2023 - "This review mainly focuses on various heterocyclic scaffolds, and their specific inhibitory targets against leishmaniasis, particularly those from the polyamine biosynthesis pathway and DNA topoisomerases with estimated activity studies of various heterocyclic analogs in terms of their IC50 or EC50 value, reported molecular docking analysis from available published literatures."

Related Drugs and Biologics

1.	Enzymes
2.	DNA (Deoxyribonucleic Acid)
3.	Anti-Bacterial Agents (Antibiotics)
4.	DNA Topoisomerase IV (Topoisomerase IV)
5.	ErbB Receptors (EGF Receptor)
6.	DNA Gyrase
7.	Quinolones
8.	Metals
9.	Histone Deacetylases (Histone Deacetylase)
10.	Ciprofloxacin (Cipro)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)