Basic Amino Acid Transport Systems

Amino acid transporter systems capable of transporting basic amino acids (AMINO ACIDS, BASIC).

Also Known As:

Amino Acid Transport Systems, Basic; Basic Amino Acid Transport Proteins; Cationic Amino Acid Transport Proteins; Cationic Amino Acid Transporters; Amino Acid Transport Systems, Cationic; Basic Amino Acid Transport Protein; Basic Amino Acid Transport System; Cationic Amino Acid Transport Protein; Cationic Amino Acid Transport System; Cationic Amino Acid Transport Systems; Cationic Amino Acid Transporter

Networked: 59 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Amino Acid Transport Systems: 812
        Basic Amino Acid Transport Systems: 59
        ornithine transporter: 13
        Amino Acid Transport System y+: 1
        Amino Acid Transport System y+L: 1
        arginine permease: 1
        glutamine permease: 1
        mouse LAT3 protein: 1
        Arabidopsis AAP3 protein
        Arabidopsis AAP5 protein
        Arabidopsis AAT1 protein
        Arabidopsis Bac1 protein
        Arabidopsis Bac2 protein
        Arabidopsis cationic amino acid transporter 2
        Arabidopsis cationic amino acid transporter 3
        Arabidopsis cationic amino acid transporter 4
        Arabidopsis LHT1 protein
        Aspergillus nidulans Amc-1 protein
        Bacteria histidine permease
        C elegans LAAT-1 protein
        Corynebacterium glutamicum LysE protein
        Corynebacterium glutamicum LysG protein
        Corynebacterium glutamicum lysI protein
        E coli ArtJ protein
        E coli glnP protein
        E coli lysP protein
        E coli SstT protein
        E coli YbjE protein
        human SLC25A2 protein
        human SLC3A1 protein
        human SLC66A1 protein
        human SLC7A2 protein
        human SLC7A3 protein
        human SLC7A6 protein
        human SLC7A9 protein
        mouse Slc3a1 protein
        mouse Slc7a2 protein
        mouse Slc7a3 protein
        mouse Slc7a9 protein
        Oryctolagus cuniculus rBAT protein
        rat Slc3a1 protein
        rat Slc7a2 protein
        rat Slc7a3 protein
        S cerevisiae Avt4 protein
        S cerevisiae CAN1 protein
        S cerevisiae LYP1 protein
        S cerevisiae Vba5 protein
        sodium-dependent glutamine transporter
        zebrafish slc7a3a protein
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Amino Acid Transport Systems: 812
        Basic Amino Acid Transport Systems: 59
        ornithine transporter: 13
        Amino Acid Transport System y+: 1
        Amino Acid Transport System y+L: 1
        arginine permease: 1
        glutamine permease: 1
        mouse LAT3 protein: 1
        Arabidopsis AAP3 protein
        Arabidopsis AAP5 protein
        Arabidopsis AAT1 protein
        Arabidopsis Bac1 protein
        Arabidopsis Bac2 protein
        Arabidopsis cationic amino acid transporter 2
        Arabidopsis cationic amino acid transporter 3
        Arabidopsis cationic amino acid transporter 4
        Arabidopsis LHT1 protein
        Aspergillus nidulans Amc-1 protein
        Bacteria histidine permease
        C elegans LAAT-1 protein
        Corynebacterium glutamicum LysE protein
        Corynebacterium glutamicum LysG protein
        Corynebacterium glutamicum lysI protein
        E coli ArtJ protein
        E coli glnP protein
        E coli lysP protein
        E coli SstT protein
        E coli YbjE protein
        human SLC25A2 protein
        human SLC3A1 protein
        human SLC66A1 protein
        human SLC7A2 protein
        human SLC7A3 protein
        human SLC7A6 protein
        human SLC7A9 protein
        mouse Slc3a1 protein
        mouse Slc7a2 protein
        mouse Slc7a3 protein
        mouse Slc7a9 protein
        Oryctolagus cuniculus rBAT protein
        rat Slc3a1 protein
        rat Slc7a2 protein
        rat Slc7a3 protein
        S cerevisiae Avt4 protein
        S cerevisiae CAN1 protein
        S cerevisiae LYP1 protein
        S cerevisiae Vba5 protein
        sodium-dependent glutamine transporter
        zebrafish slc7a3a protein

Experts

1.	Näntö-Salonen, Kirsti: 3 articles (10/2015 - 07/2003)
2.	Simell, Olli: 3 articles (10/2015 - 07/2003)
3.	Closs, Ellen I: 2 articles (12/2015 - 11/2010)
4.	Kurko, Johanna: 2 articles (10/2015 - 03/2012)
5.	Mykkänen, Juha: 2 articles (10/2015 - 03/2012)
6.	Niinikoski, Harri: 2 articles (10/2015 - 03/2012)
7.	Tanner, Laura: 2 articles (10/2015 - 03/2012)
8.	Tringham, Maaria: 2 articles (10/2015 - 03/2012)
9.	Dunse, Matthias: 2 articles (04/2010 - 01/2010)
10.	Garreis, Fabian: 2 articles (04/2010 - 01/2010)

Related Diseases

1.	Neoplasms (Cancer) 10/16/2023 - "In vitro experiments on cell transport mechanisms showed that [18F]7 was similar to (2S,4S)4-[18F]FPArg and was transported into tumor cells by cationic amino acid transporters. " 10/01/2023 - "Research progress on the role of cationic amino acid transporter (CAT) family members in malignant tumors and immune microenvironment." 04/01/2019 - "PQ loop repeat-containing (PQLC)2 is a cationic amino acid transporter that might be involved in cancer progression. " 10/31/2017 - "Preliminary mechanistic studies suggest that the internalization of Tc2 is linked to the cationic amino acid transporters, namely system y+. This finding might open the way towards the development of novel families of metal-based radiotracers for probing metabolically active cancer cells." 07/21/2023 - "Cationic amino acid transporters (CATs) facilitate arginine transport across membranes and maintain its levels in various tissues and organs, but their overexpression has been associated with severe cancers. "
2.	Choriocarcinoma 09/01/2002 - "To study the cationic amino-acid transporter hCAT-2B of human placenta, total RNA was harvested from primary cultured trophoblast and from the BeWo choriocarcinoma cell line (b30 clone) and used for reverse transcription (RT) and polymerase chain reaction (PCR). " 09/01/1999 - "To identify the cationic amino acid transporters of human placenta, total RNA was harvested from cultured trophoblast and from the BeWo choriocarcinoma cell line, b30 clone, and used for reverse transcription (RT) and polymerase chain reaction (PCR). "
3.	Breast Neoplasms (Breast Cancer) 04/01/2011 - "Arginine uptake is mediated by members of the cationic amino acid transporter (CAT) family and may coincide with induction of nitric oxide synthase (NOS) for the production of NO. The present study investigated the CAT isoforms and PRL/E2 regulation of CAT and NOS in breast cancer cell lines. "
4.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 09/01/2021 - "The aim of this study was to investigate alteration of cationic amino acid transporter (CAT-1) activity in the transport of lysine and the pretreatment effect of lysine on pro-inflammatory states in an amyotrophic lateral sclerosis cell line. " 09/01/2021 - "Change in Cationic Amino Acid Transport System and Effect of Lysine Pretreatment on Inflammatory State in Amyotrophic Lateral Sclerosis Cell Model."
5.	Autism Spectrum Disorder 12/01/2015 - "In this study, we identified a missense variant in SLC7A3, encoding the CAT-3 cationic amino acid transporter, on chromosome X by exome sequencing in two brothers with autism spectrum disorder (ASD). " 12/01/2015 - "Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders."

Related Drugs and Biologics

1.	Arginine (L-Arginine)
2.	Nitric Oxide Synthase (NO Synthase)
3.	Lysine (L-Lysine)
4.	Protein Isoforms (Isoforms)
5.	RNA (Ribonucleic Acid)
6.	Metals
7.	Amino Acids
8.	Amino Acid Transport Systems (Amino Acid Transporter)
9.	Messenger RNA (mRNA)
10.	Proteins (Proteins, Gene)