|1.||Saito, Akihiko: 12 articles (01/2014 - 08/2003)|
|2.||Christensen, Erik I: 8 articles (06/2015 - 07/2004)|
|3.||Gejyo, Fumitake: 8 articles (05/2012 - 08/2003)|
|4.||Nielsen, Rikke: 7 articles (10/2014 - 07/2008)|
|5.||Takeda, Tetsuro: 7 articles (05/2012 - 08/2003)|
|6.||Carro, Eva: 6 articles (01/2015 - 11/2005)|
|7.||Iino, Noriaki: 6 articles (05/2012 - 08/2003)|
|8.||Kaseda, Ryohei: 6 articles (05/2012 - 04/2005)|
|9.||Willnow, Thomas E: 6 articles (11/2010 - 02/2003)|
|10.||Spuch, Carlos: 5 articles (01/2015 - 11/2005)|
05/01/2015 - "An improvement in albuminuria was likely due to the reduction in tubular size, reduced leptinaemia and maintenance of megalin expression levels. "
10/01/2012 - "In conclusion, these data suggest that the increase in albuminuria that accompanies bardoxolone methyl administration may result, at least in part, from reduced expression of megalin, which seems to occur without adverse effects and with strong induction of Nrf2 targets."
05/01/2012 - "Urinary C-megalin levels were significantly high in patients with normoalbuminuria, were elevated in line with increased albuminuria, and showed a better association with estimated glomerular filtration rate (eGFR) (<60 mL/min/1.73 m(2)) than did urinary albumin. "
12/01/2002 - "Attempts to inhibit DAF function with anti-DAF Abs did not affect the quantity of complement activation by these anti-megalin Abs, nor did it lead to development of abnormal albuminuria. "
09/01/2001 - "In conclusion, albuminuria in early-stage diabetic rats can be partly explained by a decreased albumin endocytosis with reduced megalin expression and with increased lipid peroxidation in the proximal tubule."
|2.||Alzheimer Disease (Alzheimer's Disease)
01/01/2015 - "Soluble Megalin is Reduced in Cerebrospinal Fluid Samples of Alzheimer's Disease Patients."
01/01/2014 - "Alzheimer's disease-like impaired cognition in endothelial-specific megalin-null mice."
01/01/2012 - "In neurons the most important are LRP-1 and LRP-2, even it is thought that a causal factor in Alzheimer's disease (AD) is the malfunction of this process which cause impairment intracellular signaling as well as storage and/or release of nutrients and toxic compounds. "
01/30/2011 - "LRP2 (also called megalin) plays a potential key role in the pathogenesis of Alzheimer's disease (AD). "
06/05/2010 - "A megalin polymorphism associated with promoter activity and Alzheimer's disease risk."
06/15/2008 - "Preliminary results suggest that common genetic variation within the megalin gene could alter both risk of recurrence/progression and prostate-specific cancer mortality. "
05/01/2015 - "We furthermore show that a panel of tumor-derived melanoma cell lines express LRP2/megalin endogenously. "
05/01/2015 - "Melanoma tumors frequently acquire LRP2/megalin expression, which modulates melanoma cell proliferation and survival rates."
05/01/2012 - "The siRNA transfection of these megalin-rich chemo-treated cancer cells was improved by three-fold when the siRNAs were delivered by Ap-LPNs. "
05/01/2013 - "The genotyping of GSTM1, GSTT1 polymorphisms, and 2 nonsynonymous single nucleotide polymorphisms (SNPs) at megalin genes, rs2075252 and rs2228171, were performed in 68 children diagnosed with solid tumors who received cisplatin-based chemotherapy. "
01/01/2011 - "This was associated with the protection against the loss of megalin/cubilin and an increase in TGF-β(1), IL-1β, and fibrosis in the kidney. "
11/01/2013 - "Lysosomal protein accumulation in the proximal tubule, mediated by megalin and cubilin endocytosis of increased amounts of filtered protein, is thought to result in inflammation and fibrosis. "
01/01/2012 - "Ren2 rats displayed increases in urine levels of the PTC brush border lysosomal enzyme N-acetyl-β-aminoglycosidase (β-NAG) in conjunction with reductions in PTC megalin, the apical membrane adherens protein T-cadherin and basolateral α-(E)-catenin, and fibrosis. "
01/01/2002 - "New information about the role of cubilin and megalin in the reabsorption of filtered albumin in the proximal tubule may contribute to the elucidation of the mechanisms of the tubulotoxicity of proteinuria; inhibition of albumin reabsorption in nephrotic subjects could lower the risk of interstitial fibrosis and progressive renal insufficiency."
01/01/2011 - "Megalin/ cubilin-mediated endocytosis by proximal tubule cells of increased quantities of filtered proteins (protein overloading) in glomerular diseases appears to evoke cell stress responses resulting in increased inflammatory cytokines leading to tubulointerstitial inflammation and fibrosis. "
|5.||Membranous Glomerulonephritis (Membranous Nephropathy)
10/01/2000 - "This is the first study to show that there is increased expression of the cytoplasmic tail-containing form of gp600/megalin in the glomeruli of rats with this disease and its role in active Heymann nephritis is discussed."
11/01/2009 - "The ELISPOT against fractions of soluble autologous kidney extracts separated by an FPLC gel-filtration system indicated a preferential response to megalin, a high molecular weight protein that has been shown to be involved in experimental Heymann nephritis. "
12/01/2007 - "Immunization with megalin induces active Heymann nephritis, which reproduces features of human idiopathic membranous glomerulonephritis. "
07/01/2006 - "It was shown previously that an N-terminal fragment (nM60) that encompasses amino acid residues 1 to 563 of megalin could induce active Heymann nephritis (AHN) as efficiently as the native protein. "
07/01/2006 - "Nested N-terminal megalin fragments induce high-titer autoantibody and attenuated Heymann nephritis."
|1.||intrinsic factor-cobalamin receptor
|2.||Small Interfering RNA (siRNA)
|3.||Insulin-Like Growth Factor I (IGF-1)
|4.||LDL-Receptor Related Protein 2
|6.||Complementary DNA (cDNA)
|1.||Tissue Therapy (Cell Therapy)
|3.||Drug Therapy (Chemotherapy)