Low Density Lipoprotein Receptor-Related Protein-2

An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.

Also Known As:

Antigen GP 330, Nephritis; GP330 Antigen; Glycoprotein 330; Heyman's Nephritis Antigen GP330; Heymann Nephritis Antigen GP330; LRP-2 Receptor; Nephritis Antigen (GP330); Renal Glycoprotein GP330; GP330, Renal Glycoprotein; Glycoprotein GP330, Renal; LDL Receptor Related Protein 2; LRP 2 Receptor; Low Density Lipoprotein Receptor Related Protein 2; LDL-Receptor Related Protein 2; Low-Density Lipoprotein Receptor-Related Protein-2; Megalin

Networked: 323 relevant articles (9 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Saito, Akihiko: 23 articles (08/2022 - 08/2003)
2.	Nielsen, Rikke: 16 articles (08/2021 - 07/2008)
3.	Christensen, Erik I: 13 articles (01/2021 - 07/2004)
4.	Willnow, Thomas E: 10 articles (08/2021 - 02/2003)
5.	Hosojima, Michihiro: 9 articles (01/2022 - 01/2007)
6.	Kaseda, Ryohei: 9 articles (12/2019 - 04/2005)
7.	Hirayama, Yoshiaki: 8 articles (08/2022 - 05/2012)
8.	Carro, Eva: 8 articles (01/2020 - 11/2005)
9.	Gejyo, Fumitake: 8 articles (05/2012 - 08/2003)
10.	Kabasawa, Hideyuki: 7 articles (12/2021 - 04/2011)

Related Diseases

1.	Albuminuria 05/01/2015 - "An improvement in albuminuria was likely due to the reduction in tubular size, reduced leptinaemia and maintenance of megalin expression levels. " 01/01/2022 - "This study examined whether urinary C-megalin reflects renal function or albuminuria in diabetes. " 01/01/2022 - "Association of urinary C-megalin with albuminuria and renal function in diabetes: a cross-sectional study (Diabetes Distress and Care Registry at Tenri [DDCRT 21])." 01/01/2019 - "The loss of megalin, co-localized with A1AR at PTC, was associated with the level of albuminuria in diabetic patients and mice. " 01/01/2018 - "In diabetic it-ACE mice, despite hyperfiltration, the absence of renal tubular ACE greatly reduced tubulointerstitial injury and albuminuria and increased renal megalin expression compared with diabetic wild-type and diabetic ACE 3/9 mice. "
2.	Neoplasms (Cancer) 09/09/2021 - "Moreover, MTs and megalin were found to co-express and interact in cancer tissue, and their expression positively correlated within the overall study group. " 03/24/2023 - "Although megalin might be involved in tumor growth and invasiveness through several mechanisms, its role has been understudied in the field of molecular oncology so far. " 09/09/2021 - "Findings of prominent nuclear and chromosomal megalin expression suggest that it undergoes regulated intramembrane proteolysis upon MTs binding, indicating its ability to directly affect gene expression and cellular division in cancer tissue. " 04/01/2021 - "The data emphasize the diagnostic power of combined MT/megalin analysis in pre-cancer screening." 12/01/2020 - "LC-NPs also localized selectively to megalin-expressing RCC tumors in mice. "
3.	Fibrosis (Cirrhosis) 01/01/2021 - "Monolayers exhibited elevation of some tubular injury molecules-including molecules related to fibrosis (COL1A1 and STAT6) and dedifferentiation (SNAI2)-and a loss of cell identity, evident by reduction in megalin (LRP2). " 01/01/2019 - "These data show the significance of TGF-ß and the SMAD2/3 signalling pathway in the regulation of megalin and explain the decreased megalin levels observed under conditions in which TGF-ß is upregulated, including fibrosis-associated diseases and cancer." 01/01/2011 - "This was associated with the protection against the loss of megalin/cubilin and an increase in TGF-β(1), IL-1β, and fibrosis in the kidney. " 05/26/2021 - "The self-assembled K3-HBc/CLT could specifically target tubular epithelial cells via affinity with K3 ligand binding to the megalin receptor, significantly attenuating renal fibrosis. " 01/01/2019 - "Megalin expression is reduced in diseases associated with fibrosis, including diabetic nephropathy, hepatic fibrosis and cholelithiasis, as well as in some breast and prostate cancers. "
4.	Acute Kidney Injury (Acute Renal Failure) 12/01/2022 - "Moreover, ABP-EVs had higher renal retention than NC-EVs in mice with acute kidney injury through a complex mechanism involving microvascular injury and megalin-mediated endocytosis. " 01/01/2014 - "Megalin in acute kidney injury: foe and friend." 01/01/2018 - "The objective of this study was to investigate the potential relation of megalin receptor injury with nuclear factor-kappa B (NF-κB) upregulation in acute kidney injury rat model. " 01/01/2018 - "Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats." 12/01/2022 - "Megalin blockade with cilastatin ameliorates multiple wasp sting-induced acute kidney injury in rats."
5.	Disease Progression 01/01/2014 - "There is a possibility that urinary C-megalin is an independent predictor of disease progression of IgAN. " 03/24/2023 - "The present study aimed to evaluate the impact of megalin expression in oral squamous cell carcinoma (OSCC) on disease progression. " 01/01/2022 - "The addition of renal megalin mRNA to a model with traditional risk factors improved risk prediction of disease progression (C statistic from 0.76 to 0.80; integrated discrimination index: 0.04 [95% CI: 0.02-0.07]). "

Related Drugs and Biologics

1.	intrinsic factor-cobalamin receptor
2.	Proteins (Proteins, Gene)
3.	Messenger RNA (mRNA)
4.	NPHS2 protein
5.	Small Interfering RNA (siRNA)
6.	Cilastatin
7.	Insulin-Like Growth Factor I (IGF-1)
8.	CLC-5 chloride channel
9.	Vitamin D
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Glycemic Control
2.	Therapeutics
3.	Cell- and Tissue-Based Therapy (Cell Therapy)
4.	Thyroidectomy
5.	Nephrectomy