Serum Response Factor

A MADS domain-containing transcription factor that binds to the SERUM RESPONSE ELEMENT in the promoter-enhancer region of many genes. It is one of the four founder proteins that structurally define the superfamily of MADS DOMAIN PROTEINS.

Also Known As:

Networked: 271 relevant articles (0 outcomes, 16 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tabuchi, Akiko: 8 articles (11/2021 - 09/2006)
2.	Tsuda, Masaaki: 7 articles (11/2021 - 09/2006)
3.	Neubig, Richard R: 7 articles (01/2019 - 08/2007)
4.	Prencipe, Maria: 6 articles (01/2022 - 05/2013)
5.	Yu-Wai-Man, Cynthia: 6 articles (03/2021 - 07/2014)
6.	Li, Zhenlin: 6 articles (01/2020 - 10/2006)
7.	Mericskay, Mathias: 6 articles (01/2020 - 07/2008)
8.	Ishikawa, Mitsuru: 6 articles (10/2017 - 09/2006)
9.	Nordheim, Alfred: 6 articles (01/2017 - 12/2007)
10.	Chung, Myoung Ja: 6 articles (01/2014 - 12/2007)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer." 07/04/2017 - "The serum response factor (SRF) plays key roles in both EMT and differentiation of pericytes, and may inherently confer the pericyte attributes on EMT cancer cells. " 08/16/2002 - "High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling." 03/01/2013 - "Recent studies indicate that serum response factor (SRF) is highly expressed in tumors such as hepatocellular, thyroid, esophageal and lung carcinoma. " 08/16/2002 - "In this study, we have analyzed the role of the serum response factor and mechanisms that regulate its activity in tumor progression utilizing a multistage model of mouse skin carcinogenesis. "
2.	Hypoxia (Hypoxemia) 06/25/2006 - "We observed the changes of these three kinds of HUVECs (HUVECs, N17Rac1-HUVECs, V12Rac1-HUVECs) after hypoxia for 48 h and 96 h, the expression and localization of serum response factor (SRF), which is one of the downstream signal molecules of Rac1, were also investigated. " 09/12/1997 - "Mutations in the binding site for the ternary complex factor Elk-1 and the serum response factor abolished this induction, indicating that a ternary complex at the serum response element is necessary for the induction of the c-fos gene under hypoxia. " 01/01/2017 - "The aim of study was to investigate the involvement of hypoxia-induced upregulation of serum response factor (SRF) and its downstream effector, B cell leukemia-2 (Bcl-2), in hypoxia-induced pulmonary hypertension (PH). " 01/01/2022 - "Glucose-6-phosphate dehydrogenase and MEG3 controls hypoxia-induced expression of serum response factor (SRF) and SRF-dependent genes in pulmonary smooth muscle cell." 03/01/2014 - "Gel-shift assay showed increased DNA-binding activity of SRF (serum response factor) after hypoxia. "
3.	Carcinogenesis 01/01/2020 - "Invertebrates encode a single G12/13 homolog that participates in cytoskeletal changes yet appears to lack signalling to SRF (serum response factor), a transcriptional activator stimulated by mammalian Gα12 and Gα13 to promote growth and tumorigenesis. " 08/16/2002 - "In this study, we have analyzed the role of the serum response factor and mechanisms that regulate its activity in tumor progression utilizing a multistage model of mouse skin carcinogenesis. " 02/19/2023 - "Serum Response Factor-Regulated IDO1/Kyn-Ahr Pathway Promotes Tumorigenesis of Oral Squamous Cell Carcinoma." 05/08/2023 - "Serum response factor (SRF) and myocardial-associated transcription factor-A (MRTF-A) had different regulatory effects on the tumorigenesis and development in different cancers. " 01/01/2014 - "Serum response factor (SRF) is a transcription factor that plays a central role in carcinogenesis and tumor progression in several types of cancers. "
4.	Renal Cell Carcinoma (Grawitz Tumor) 01/01/2020 - "Increased serum response factor activity induces epithelial-mesenchymal transition, migration and invasion in 786-O cells, and facilitates the progression of renal cell carcinoma. " 01/01/2020 - "Serum response factor interacted with several important differentially expressed genes in renal cell carcinoma. " 01/01/2020 - "A xenograft nude mouse model was established to explore whether serum response factor affected the tumorigenic ability of renal cell carcinoma cells. " 01/01/2020 - "To explore the regulation and function of serum response factor in epithelial-mesenchymal transition in renal cell carcinoma. " 01/01/2020 - "Serum response factor increases renal cell carcinoma migration and invasion through promoting epithelial-mesenchymal transition."
5.	Leukemia 09/01/2006 - "Recent studies have identified megakaryocytic acute leukemia (MAL), a serum response factor (SRF) co-activator, as a key component of a signaling pathway linking changes in the actin cytoskeleton to SRF-mediated transcription. " 01/01/2021 - "The dominant component of this model correlated with αSMA- PDGFRα+ fibroblast-like cell content (p = 2.4E-05) and Arg1+ macrophage content (p = 2.2E-04) and was driven by serum response factor (SRF), possibly in a megakaryoblastic leukemia-1/2 (MKL1/2) dependent manner. " 11/01/2020 - "Megakaryoblastic leukemia 1 (MKL1) promotes the regulation of essential cell processes, including actin cytoskeletal dynamics, by coactivating serum response factor. " 01/01/2020 - "Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor and together they regulate transcription of actin cytoskeleton genes. " 01/01/2017 - "Megakaryoblastic leukemia (MKL)/serum-response factor (SRF)-mediated gene transcription is a highly conserved mechanism that connects dynamic reorganization of the actin cytoskeleton to regulation of expression of a wide range of genes, including SRF itself and many important structural and regulatory components of the actin cytoskeleton. "

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