Singlet Oxygen

An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.

Also Known As:

Networked: 1495 relevant articles (59 outcomes, 79 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhu, Timothy C: 15 articles (01/2020 - 02/2009)
2.	Kim, Michele M: 13 articles (01/2020 - 02/2013)
3.	Akkaya, Engin U: 11 articles (02/2022 - 07/2005)
4.	Huang, Wei: 11 articles (01/2021 - 08/2017)
5.	Penjweini, Rozhin: 11 articles (01/2020 - 12/2013)
6.	Bauer, Georg: 11 articles (01/2019 - 07/2012)
7.	Yang, Hong: 9 articles (05/2022 - 01/2014)
8.	Liu, Bin: 9 articles (07/2021 - 08/2015)
9.	Liu, Shujuan: 9 articles (01/2021 - 08/2017)
10.	Zhao, Qiang: 9 articles (01/2021 - 08/2017)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2011 - "The β-substituted dihydroxychlorin products exhibit a strong absorption in the red spectral region, a high singlet oxygen quantum yield, and were found to be highly effective in in vitro assays against HT-29 tumor cells." 01/01/2019 - "In vivo experiments also revealed that tumors can be very efficiently eliminated by the designed nanoparticles under light irradiation with the ability to regulate in vivo generation of singlet oxygen. " 09/13/2023 - "Further mechanism studies revealed that upon irradiation with visible light, complexes 3 and 4 generated a high level of singlet oxygen (1O2), and their in vitro anticancer activities against human non-small-cell lung (A549), cervical (HeLa) and squamous (A431) cancer cells were significantly improved. " 11/09/2020 - "The nanoparticle transformation into fibrils improved their singlet oxygen generation ability and enabled high accumulation and long-term retention at tumor sites. " 01/01/2019 - "Among them, the singlet oxygen produced by the Fenton reaction is particularly effective in killing tumor cells. "
2.	Phototoxic Dermatitis (Phototoxicity) 11/08/2021 - "The ACQ effect could be significantly inhibited by introducing flexible chains and increasing Mw, leading to the improvement in the singlet oxygen quantum yield and phototoxicity simultaneously. " 11/27/2019 - "The obtained pPS could be self-assembled into the nanocomplexes based on the electrostatic effect with a high PS loading capacity, improved singlet oxygen generation ability, and efficient phototoxicity. " 09/01/2011 - "Studies carried out on cellular uptake, photostability and singlet oxygen generation suggest that enhanced phototoxicity is primarily due to the enhanced uptake of the drug-nanoparticle complex." 09/01/2023 - "This phototoxicity was accompanied by an increase in singlet oxygen but a decrease in type I ROS when CSE and SSL were combined in vitro. " 08/01/2023 - "Overall these results highlight the key role of the H-abstraction process over singlet oxygen sensitization as a primary photochemical pathway strictly dictated by the specific features of the microenvironment, providing new insights into the photoreactivity of CUR in biocompatible hosts that can also be useful for a better understanding of its phototoxicity mechanism."
3.	Hypoxia (Hypoxemia) 01/01/2022 - "Fractionated delivery of singlet oxygen (1O2) is a wise approach to relieving hypoxia, thus enhancing the therapeutic efficacy. " 11/21/2022 - "Targeted Singlet Oxygen Delivery: A Bioorthogonal Metabolic Shunt Linking Hypoxia to Fast Singlet Oxygen Release." 01/01/2010 - "There is an optimum fluence rate at which the greatest singlet oxygen dose can be delivered before hypoxia becomes limiting. " 06/15/2021 - "The IR820 produced singlet oxygen (1O2) under near-infrared (NIR) laser irradiation and concomitantly tumorous abnormality exacerbated hypoxia. " 01/01/2021 - "Singlet Oxygen Generation in Dark-Hypoxia by Catalytic Microenvironment-Tailored Nanoreactors for NIR-II Fluorescence-Monitored Chemodynamic Therapy."
4.	Photosensitivity Disorders (Photodermatitis) 01/01/2019 - "Oxidative Capacity Storage of Transient Singlet Oxygen from Photosensitization with a Redox Mediator for Improved Chemiluminescent Sensing." 10/02/2022 - "Moreover, cell membrane damage and production of cytotoxic singlet oxygen (1O2) was proved as main photosensitization mechanism. " 06/01/2022 - "Quantum effects in photosensitization: the case of singlet oxygen generation by thiothymines." 01/01/2022 - "Our results indicate that J-type aggregates in NPs can not only bring significantly red-shifted emission, negatively charged surface, and high photostability, but also enable a significant 5-fold increase in singlet oxygen generation efficiency compared to that in the nonaggregate state, providing strong experimental evidence for the superiority of J-aggregates in enhancing photosensitization. " 11/22/2021 - "Here the authors present, inter alia, the single crystal X-ray structures of all free-base diketone isomers and a comparative description of their UV-vis absorption spectra in neutral and acidic solutions, and fluorescence emission and singlet oxygen photosensitization properties, Magnetic Circular Dichroism (MCD) spectra, and singlet excited state lifetimes. "
5.	Infections 01/01/2023 - "A Targeting Singlet Oxygen Battery for Multidrug-Resistant Bacterial Deep-Tissue Infections." 09/01/2017 - "GNPDEX-ConA with monomeric form of MB departs maximum fluorescence decay time (τf: 1.7ns in HSA) and singlet oxygen (ΔΦ; 0.84) for improved activity in albumin rich infection sites. " 01/01/2021 - "Furthermore, the released TAPP became protonated in the acidic infection area (pH = 5.5) and then enhanced its photodynamic antibacterial efficacy by producing higher singlet oxygen (1O2) levels under light irradiation. " 07/01/2016 - "Due to infection, a reduction in carotenoid content was observed which leads to reduced quenching of singlet oxygen. " 02/01/2014 - "The efficient generation of singlet oxygen makes fluorescent chlorophyll catabolites phototoxic, but might also be useful as a (stress) signal and for defense of the plant tissue against infection by pathogens. "

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	Photosensitizing Agents (Photosensitizers)
3.	Oxygen (Dioxygen)
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Hydroxyl Radical
6.	Coloring Agents (Dyes)
7.	Superoxides (Superoxide)
8.	Hydrogen Peroxide (Hydroperoxide)
9.	Free Radicals
10.	Solutions

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Therapeutics
3.	Lasers (Laser)
4.	Photothermal Therapy
5.	Phototherapy (Light Therapy)