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Carboxypeptidase U (TAFI)

A metallocarboxypeptidase that removes C-terminal lysine and arginine from biologically active peptides and proteins thereby regulating their activity. It is a zinc enzyme with no preference shown for lysine over arginine. Pro-carboxypeptidase U in human plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
Also Known As:
TAFI; Thrombin Activatable Fibrinolysis Inhibitor; Carboxypeptidase R; Plasma Procarboxypeptidase B; Procarboxypeptidase U; Arginine Carboxypeptidase; Thrombin-Activatable Fibrinolysis Inhibitor
Networked: 343 relevant articles (9 outcomes, 95 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Meijers, Joost C M: 11 articles (02/2013 - 01/2002)
2. Morser, John: 10 articles (10/2013 - 01/2002)
3. Taguchi, Osamu: 9 articles (10/2013 - 02/2003)
4. Gabazza, Esteban C: 9 articles (10/2013 - 02/2002)
5. Gils, A: 8 articles (02/2014 - 02/2005)
6. Meijers, J C M: 7 articles (11/2015 - 10/2003)
7. Declerck, Paul J: 7 articles (02/2015 - 02/2006)
8. Gils, Ann: 7 articles (02/2015 - 02/2006)
9. Declerck, P J: 7 articles (02/2014 - 02/2008)
10. Suzuki, Koji: 7 articles (04/2009 - 02/2002)

Related Diseases

1. Thrombosis (Thrombus)
2. Stroke (Strokes)
3. Fibrosis (Cirrhosis)
4. Hypothyroidism
5. Insulin Resistance

Related Drugs and Biologics

1. Carboxypeptidase U (TAFI)
2. Antigens
3. Thyroxine (Levothyroxine)
4. recombinant FVIIa (rFVIIa)
5. Thrombin
6. lipoprotein-associated coagulation inhibitor (TFPI)
7. Plasminogen Activator Inhibitor 1
8. Plasminogen Activators (Plasminogen Activator)
9. Fibrinolysin
10. Tissue Plasminogen Activator (Alteplase)

Related Therapies and Procedures

1. Thrombolytic Therapy
2. Hormone Replacement Therapy (Therapy, Hormone Replacement)
3. Stents
4. Transplantation (Transplant Recipients)
5. Renal Dialysis (Hemodialysis)