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Inherited Blood Coagulation Disorders

Subscribe to New Research on Inherited Blood Coagulation Disorders

Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.

Also Known As:

Blood Coagulation Disorders, Inherited; Hereditary Blood Coagulation Disorders; Coagulation Disorder, Hereditary; Coagulation Disorder, Inherited; Coagulation Disorders, Hereditary; Hereditary Coagulation Disorder; Inherited Coagulation Disorder; Coagulation Disorders, Inherited; Hereditary Coagulation Disorders; Inherited Coagulation Disorders

Networked: 50 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Thrombosis (Thrombus)
2.	HIV Infections (HIV Infection)
3.	Hemophilia A (Haemophilia)
4.	Hemorrhage
5.	Afibrinogenemia (Fibrinogen Deficiency)

Experts

1.	Peyvandi, Flora: 3 articles (03/2014 - 09/2004)
2.	De Cristofaro, Raimondo: 2 articles (03/2014 - 09/2013)
3.	Menegatti, Marzia: 2 articles (03/2014 - 09/2004)
4.	Tagliaferri, Annarita: 2 articles (09/2013 - 05/2006)
5.	Rodeghiero, Francesco: 2 articles (09/2013 - 12/2008)
6.	Castaman, Giancarlo: 2 articles (09/2013 - 12/2008)
7.	Giacomelli, Sofia H: 2 articles (09/2013 - 12/2008)
8.	Karimi, Mehran: 2 articles (04/2009 - 09/2004)
9.	Asselta, Rosanna: 2 articles (04/2009 - 12/2008)
10.	Abolghasemi, Hassan: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Inherited Blood Coagulation Disorders:

1.	Prothrombin (Factor II)IBA 09/01/2013 - "Prothrombin (factor II [FII]) deficiency is a rare inherited coagulation disorder, having a prevalence of approximately 1 in 2,000,000. " 02/01/2004 - "The purpose of this study was to assess the incidence of central venous catheter (CVC)-related thrombosis and the contribution of two common inherited coagulation disorders (factor V Leiden, prothrombin G20210A mutation) to this complication in a large hospital population. " 01/01/2004 - "Hyperhomocysteinemia and other newly recognized inherited coagulation disorders (factor V Leiden and prothrombin gene mutation) in patients with idiopathic cerebral vein thrombosis." 09/01/2013 - "Inherited coagulation disorders constitute a broad spectrum of coagulation factor deficiencies that include X-linked factor (F)VIII or FIX deficiency that causes haemophilia, and autosomal recessive disorders producing heterogeneous deficiencies in fibrinogen (FI), prothrombin (FII), FV, FVII, FX, FXI, FXIII and combined FV+FVIII. "
2.	factor V LeidenIBA 01/01/2003 - "Factor V Leiden mutation has emerged as one of the leading abnormalities in inherited blood coagulation disorders, resulting in a markedly increased risk for deep leg vein thrombosis. " 02/01/2004 - "The purpose of this study was to assess the incidence of central venous catheter (CVC)-related thrombosis and the contribution of two common inherited coagulation disorders (factor V Leiden, prothrombin G20210A mutation) to this complication in a large hospital population. " 01/01/2004 - "Hyperhomocysteinemia and other newly recognized inherited coagulation disorders (factor V Leiden and prothrombin gene mutation) in patients with idiopathic cerebral vein thrombosis."
3.	Zidovudine (Retrovir)FDA LinkGeneric 08/15/1991 - "One hundred ninety-three asymptomatic patients with hereditary coagulation disorders and human immunodeficiency virus (HIV) infection were studied in a controlled trial of zidovudine (ZDV) versus a placebo (with an average of 9.7 months on study). "
4.	Factor XI (Plasma Thromboplastin Antecedent)IBA 06/01/2009 - "Factor XI (FXI) deficiency is a rare inherited coagulation disorder associated with prolonged activated partial thromboplastin time. " 04/01/2009 - "Factor XI (FXI)-deficiency is a rare coagulation disorder inherited as an autosomal recessive trait, which is most common in Ashkenazi Jews, but also found in other groups like Moslems. " 01/01/2009 - "Factor XI (FXI) deficiency is a hereditary coagulation disorder observed in various mammalian species. " 09/01/2013 - "Factor XI (FXI) deficiency is an autosomal inherited coagulation disorder, characterized by an inconsistent bleeding tendency, mainly associated with injury or surgery. " 12/01/2008 - "Factor XI (FXI) deficiency is an autosomal inherited coagulation disorder characterized by bleeding symptoms mainly associated with injury or surgery. "
5.	Factor VIII (Coagulation Factor VIII)IBA 12/01/1995 - "von Willebrand type I disease is an hereditary coagulation disorder characterized by a deficiency of the factor VIII complex: VIII: C, vWF:Ag, vWF:RCoF. " 01/01/2013 - "Methylation, CpG island, promoter, intron 1 Haemophilia A is the most common X-linked inherited coagulation disorder caused by a deficiency of the factor VIII protein (FVIII). " 07/20/1999 - "Hemophilia A is the most common severe hereditary coagulation disorder and is caused by a deficiency in blood clotting factor VIII (FVIII). " 04/01/1998 - "Hemophilia A (classic hemophilia) is an hereditary coagulation disorder characterized by the absence, severe deficiency, or defective functioning of plasma coagulation factor VIII. It is inherited in an X-linked recessive manner and occurs almost exclusively in males. " 01/01/2015 - "Hemophilia A and B are inherited coagulation disorders characterized by a reduced or absent level of factor VIII or factor IX respectively. "
6.	Fibrinogen (Factor I)FDA Link 10/09/1965 - "A new inherited coagulation disorder caused by an abnormal fibrinogen ('fibrinogen Baltimore')." 10/01/2015 - "Congenital afibrinogenemia is a very rare inherited coagulation disorder characterized by absence of plasma fibrinogen (factor I). " 01/01/2010 - "Congenital afibrinogenemia is a very rare inherited coagulation disorder, characterized by virtual absence of plasma fibrinogen (factor I). " 09/01/2013 - "Inherited coagulation disorders constitute a broad spectrum of coagulation factor deficiencies that include X-linked factor (F)VIII or FIX deficiency that causes haemophilia, and autosomal recessive disorders producing heterogeneous deficiencies in fibrinogen (FI), prothrombin (FII), FV, FVII, FX, FXI, FXIII and combined FV+FVIII. "
7.	Factor IX (PTC)FDA LinkGeneric 01/01/2015 - "Hemophilia A and B are inherited coagulation disorders characterized by a reduced or absent level of factor VIII or factor IX respectively. " 09/01/2001 - "Hemophilia A and B are hereditary coagulation disorders that result from functional deficiencies of factor VIII (FVIII) or factor IX (FIX), respectively. " 09/01/1990 - "[Molecular diagnosis of inherited coagulation disorders--sequence analysis of hemophilia B patients with anti-factor IX antibodies]." 01/01/2001 - "Haemophilia is a recessively inherited coagulation disorder, in which an X-chromosome mutation causes a deficiency of either coagulation factor VIII (FVIII) in haemophilia A, or factor IX (FIX) in haemophilia B. "
8.	Factor X (Stuart Factor)IBA 03/01/2014 - "Factor X (FX) deficiency is one of the most severe among recessively inherited coagulation disorders. " 12/01/2011 - "Factor X (FX) deficiency is a rare hereditary coagulation disorder. " 12/01/2002 - "Severe factor X (FX) deficiency is one of the severest inherited coagulation disorders. "
9.	von Willebrand FactorIBA 06/01/2012 - "von Willebrand disease (VWD), the most common hereditary coagulation disorder, results from mutations in the 52-exon gene for von Willebrand factor (VWF), which encodes an 8.4-kB cDNA. " 06/01/2012 - "von Willebrand disease (VWD) is the most common inherited coagulation disorder and is typically treated by restoring the deficient von Willebrand factor (VWF) with exogenous VWF or by stimulating release of endogenous VWF with desmopressin. "
10.	Factor VII (Proconvertin)IBA 09/01/2004 - "A rare inherited coagulation disorder: combined homozygous factor VII and factor X deficiency." 08/17/2008 - "The authors describe the treatment of the bleeding complications in two female patients suffering from a rare, inherited coagulation disorder; Factor XI deficiency after having major orthopaedic and traumatologic operations by activated, recombinant Factor VII (NovoSeven, Novo Nordisk, Bagsvaerd, Denmark). "

Therapies and Procedures

1.	Catheters 02/01/2004 - "The purpose of this study was to assess the incidence of central venous catheter (CVC)-related thrombosis and the contribution of two common inherited coagulation disorders (factor V Leiden, prothrombin G20210A mutation) to this complication in a large hospital population. "
2.	Liver Transplantation 01/01/2015 - "Factor XI (FXI) deficiency (Rosenthal syndrome) is one of the rare inherited coagulation disorders with an extremely low risk of transmission by liver transplantation (LT). "
3.	Tooth Extraction (Tooth Extractions) 09/01/1997 - "Factor V deficiency is a very rare hereditary coagulation disorder and tooth extraction in the patient with factor V deficiency has not been reported except in one case. "
4.	Tattooing 11/01/2013 - "Tattooing, piercing and inherited coagulation disorders."
5.	Dental Care 02/01/2008 - "In the Irish Republic, patients with inherited bleeding disorders have their dental care co-ordinated centrally at the National Centre for Hereditary Coagulation Disorders (NCHCD), St James's Hospital, Dublin. "