|1.||Hayes, Ronald L: 5 articles (05/2015 - 02/2010)|
|2.||Mondello, Stefania: 4 articles (05/2015 - 06/2011)|
|3.||Wang, Kevin K W: 4 articles (05/2015 - 02/2010)|
|4.||Papa, Linda: 4 articles (01/2014 - 02/2010)|
|5.||Lansbury, Peter T: 4 articles (03/2009 - 10/2002)|
|6.||Tortella, Frank C: 3 articles (01/2016 - 02/2010)|
|7.||Meray, Robin K: 3 articles (03/2009 - 03/2006)|
|8.||Dave, Jitendra R: 2 articles (01/2016 - 02/2010)|
|9.||Kim, Hyun Jung: 2 articles (06/2015 - 01/2014)|
|10.||Lee, Kong-Joo: 2 articles (06/2015 - 01/2014)|
|1.||Parkinson Disease (Parkinson's Disease)
08/15/2001 - "Recent studies suggest that ubiquitin C-terminal hydrolase-L1 (UCH-L1), a neuronal deubiquitinating enzyme, represents a candidate gene responsible for either the development of familial Parkinson's disease (PD) or the protection against sporadic PD in Caucasian populations, although these findings are not fully verified in non-Caucasian populations. "
01/01/2014 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) has been proposed as one of the Parkinson's disease (PD) related genes, but the possible molecular connection between UCH-L1 and PD is not well understood. "
03/24/2009 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is linked to Parkinson's disease (PD) and memory and is selectively expressed in neurons at high levels. "
04/06/2007 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a highly expressed neuronal DUB linked to Parkinson disease; however, little is known about its specific functions or modes of regulation. "
10/18/2002 - "The assumption that each enzyme expresses a single enzymatic activity in vivo is challenged by the linkage of the neuronal enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) to Parkinson's disease (PD). "
06/30/2015 - "This study explored the role of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in the production of ROS and tumor invasion. "
03/28/2013 - "Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA."
12/01/2012 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a deubiquitinating enzyme of unknown function that is highly expressed in neurons and overexpressed in several human cancers. "
09/26/2014 - "Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines."
01/08/2009 - "Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis."
|3.||Breast Neoplasms (Breast Cancer)
01/01/2013 - "In addition, by further examining the BiNets that are significant in ER-negative breast cancer patient prognosis, we discovered a ubiquitin C (UBC) gene network that demonstrates strong prognosis power in nearly all types of breast cancer subtypes we used in this study. "
01/01/2012 - "Messenger RNA for ER (ESR1) and Ubiquitin C (UbC) were visualized using RNAscope probes and levels were quantified by quantitative in situ hybridization (qISH) on two Yale breast cancer cohorts on tissue microarrays. "
04/01/2010 - "Several reports demonstrated that the ubiquitin C terminal hydrolase-L1 (UCH-L1) has been found to be an oncogene in malignant tumors such as esophageal carcinoma, lung cancer and breast cancer. "
01/01/2008 - "Fischer 344 rats expressing human APP driven by the ubiquitin-C promoter were generated via lentiviral vector infection of Fischer 344 zygotes. "
04/01/2002 - "In the present study, which focused on rainbow trout but included eleven other species, it is shown that fish ubiquitin genetic organisation and expression are similar to those of other phylogenetic groups through the following set of observations: (a) Multiple loci were detected, (b) These loci encode repeats of ubiquitin, (c) Although the DNA sequences are not conserved, the encoded amino acid sequences are fully conserved, (d) The expression of ubiquitin was influenced by cell culture conditions and viral infection."
|5.||Brain Injuries (Brain Injury)
03/01/2012 - "To examine the concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1), a novel brain injury biomarker, in CSF and serum of severe TBI patients and their association with clinical characteristics and outcome. "
06/01/2011 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a neuron-specific enzyme that has been identified as a potential biomarker of traumatic brain injury (TBI). "
06/01/2011 - "Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids."
02/01/2010 - "Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats."
01/01/2014 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) has been established as a reliable and potential biomarker of neuronal damage after acute neurologic insults, such as ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury. "
|2.||Biological Markers (Surrogate Marker)
|5.||Glial Fibrillary Acidic Protein
|7.||AMP-Activated Protein Kinases
|8.||Dual Specificity Phosphatase 1
|9.||Fibroblast Growth Factor 3
|10.||Proteasome Endopeptidase Complex (Proteasome)