Ubiquitin C

A single protein comprised of tandem repeats of the UBIQUITIN 78-amino acid sequence. It is a product of the polyubiquitin gene which contains multiple copies of the ubiquitin coding sequence. Proteolytic processing of ubiquitin C results in the formation of individual ubiquitin molecules. This protein is distinct from POLYUBIQUITIN, which is a protein formed through isopeptide linkage of multiple ubiquitin species.

Also Known As:

Networked: 111 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hayes, Ronald L: 10 articles (10/2022 - 02/2010)
2.	Wang, Kevin K W: 6 articles (01/2021 - 02/2010)
3.	Mondello, Stefania: 5 articles (01/2016 - 06/2011)
4.	Tortella, Frank C: 4 articles (01/2016 - 02/2010)
5.	Papa, Linda: 4 articles (01/2014 - 02/2010)
6.	Lansbury, Peter T: 4 articles (03/2009 - 10/2002)
7.	Ala-Seppälä, Henna: 3 articles (01/2017 - 03/2016)
8.	Coles, Jonathan P: 3 articles (01/2017 - 03/2016)
9.	Frantzén, Janek: 3 articles (01/2017 - 03/2016)
10.	Katila, Ari J: 3 articles (01/2017 - 03/2016)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 01/01/2014 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) has been proposed as one of the Parkinson's disease (PD) related genes, but the possible molecular connection between UCH-L1 and PD is not well understood. " 03/24/2009 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is linked to Parkinson's disease (PD) and memory and is selectively expressed in neurons at high levels. " 04/06/2007 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a highly expressed neuronal DUB linked to Parkinson disease; however, little is known about its specific functions or modes of regulation. " 08/15/2001 - "Recent studies suggest that ubiquitin C-terminal hydrolase-L1 (UCH-L1), a neuronal deubiquitinating enzyme, represents a candidate gene responsible for either the development of familial Parkinson's disease (PD) or the protection against sporadic PD in Caucasian populations, although these findings are not fully verified in non-Caucasian populations. " 01/01/2017 - "Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson's disease (PD). "
2.	Traumatic Brain Injuries (Traumatic Brain Injury) 01/01/2018 - "Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Prediction of Computed Tomography Findings in Traumatic Brain Injury; a Meta-Analysis." 06/01/2011 - "Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids." 09/01/2023 - "We focused on ubiquitin C-terminal hydrolase-L1 (UCH-L1), which has been proposed as a screening tool for traumatic brain injury, and investigated whether the plasma UCH-L1 level could also be a useful biomarker in patients with non-traumatic brain injury. " 10/01/2022 - "The objective of this work was to analyze the relationships between traumatic brain injury (TBI) on computed tomographic (CT) imaging and blood concentration of glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), and S100B. " 01/01/2021 - "Evaluation of Acute Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Plasma Levels in Traumatic Brain Injury Patients with and without Intracranial Lesions."
3.	Wounds and Injuries (Trauma) 06/01/2017 - "Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries." 01/01/2018 - "We sought to validate a test combining ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP), at predetermined cutoff values, to predict traumatic intracranial injuries on head CT scan acutely after TBI. " 05/01/2015 - "We could not find reports relating ubiquitin C-terminal hydrolase-L1 and α-II spectrin breakdown products, which are widely researched in other central nervous system injuries. " 01/01/2021 - "Thorough overview of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury."
4.	Epilepsy (Aura) 01/01/2020 - "Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) enzyme levels were investigated in patients with epilepsy, epileptic seizure, remission period, and healthy individuals. " 01/01/2020 - "Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy."
5.	Neoplasms (Cancer) 06/30/2015 - "This study explored the role of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in the production of ROS and tumor invasion. " 03/28/2013 - "Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA." 11/01/2021 - "It has been reported that ubiquitin C-terminal hydrolase-L3 (UCHL3) plays an important role in cancer development; however, the role of UCHL3 in melanoma remains unclear. " 09/26/2014 - "Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines." 01/08/2009 - "Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis."

Related Drugs and Biologics

1.	Glial Fibrillary Acidic Protein
2.	Biomarkers (Surrogate Marker)
3.	Deubiquitinating Enzymes
4.	Enzymes
5.	Ubiquitin
6.	Proteins (Proteins, Gene)
7.	Spectrin
8.	Hydrolases
9.	Phosphopyruvate Hydratase (Enolase)
10.	Myelin Basic Protein

Related Therapies and Procedures

1.	Induced Hypothermia