Polyubiquitin

An oligomer formed from the repetitive linking of the C-terminal glycine of one UBIQUITIN molecule via an isopeptide bond to a lysine residue on a second ubiquitin molecule. It is structurally distinct from UBIQUITIN C, which is a single protein containing a tandemly arrayed ubiquitin peptide sequence.

Also Known As:

Networked: 138 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ryu, Kwon-Yul: 6 articles (01/2019 - 03/2008)
2.	Zhong, Bo: 4 articles (10/2020 - 01/2016)
3.	Tokunaga, Fuminori: 4 articles (01/2020 - 03/2015)
4.	Kopito, Ron R: 4 articles (01/2016 - 03/2008)
5.	Park, Chul-Woo: 3 articles (01/2019 - 10/2014)
6.	Ye, Liya: 2 articles (10/2020 - 01/2019)
7.	Zhang, Qiang: 2 articles (10/2020 - 01/2017)
8.	Ayaki, Takashi: 2 articles (01/2020 - 11/2019)
9.	Damgaard, Rune Busk: 2 articles (01/2020 - 01/2019)
10.	Ito, Hidefumi: 2 articles (01/2020 - 11/2019)

Related Diseases

1.	Infections 10/08/2023 - "Our results enable us to suggest that polyubiquitin plays an important role in DENV infection within mosquitoes." 10/01/2020 - "Mechanistically, USP29 constitutively interacts with cGAS, deconjugates K48-linked polyubiquitin chains from cGAS and stabilizes cGAS in uninfected cells or after HSV-1 infection. " 01/01/2021 - "In this study, we show that infection with coxsackievirus B3 entails a profound impairment of the protein homeostasis at virus-utilized membranes, reflected by an accumulation of ubiquitinylated proteins, including K48-linked polyubiquitin conjugates, known to direct proteins to proteasomal degradation. " 09/18/2023 - "Sde proteins have two additional activities of unclear relevance to the infection process: K63 linkage-specific deubiquitination and phosphoribosyl modification of polyubiquitin (pR-Ub). " 01/01/2018 - "Using pharmacological inhibition of actin polymerisation and a collection of actA mutants, we found that actin polymerisation prevented the colocalisation of L. monocytogenes with polyubiquitin, the autophagy receptor p62, and the autophagy protein LC3 during macrophage infection. "
2.	Bites and Stings (Sting) 11/01/2018 - "STING is modified by several types of polyubiquitin chains. " 01/01/2023 - "In HEK392T cells, PLpro removed K63-linked polyubiquitin chains from Lys289 of the stimulator of interferon genes (STING). " 01/01/2021 - "Here, we report that the deubiquitinase OTUD5 interacts with STING, cleaves its K48-linked polyubiquitin chains, and promotes its stability. " 11/01/2018 - "Mechanistically, STING translocated from the ER to the Golgi upon HSV-1 stimulation; CYLD partially accumulated with STING and interacted selectively with K48-linked polyubiquitin chains on STING, specifically removing the K48-linked polyubiquitin chains from STING and ultimately boosting the innate antiviral response. " 01/01/2017 - "Mechanistically, USP13 deconjugates polyubiquitin chains from STING and prevents the recruitment of TBK1 to the signalling complex, thereby negatively regulating cellular antiviral responses. "
3.	Breast Neoplasms (Breast Cancer) 03/24/2016 - "In this study, we identify that the specific lysine residue 447 (K447) of HSPA5 could be modified with polyubiquitin for subsequent degradation through the ubiquitin proteasomal system, leading to the suppression of cell migration and invasion of breast cancer. " 12/04/2012 - "The DNA repair function of the breast cancer susceptibility protein BRCA1 depends in part on its interaction with RAP80, which targets BRCA1 to DNA double-strand breaks (DSBs) through recognition of K63-linked polyubiquitin chains. " 03/15/2009 - "Rap80 targets the breast cancer suppressor protein BRCA1 along with Abraxas and the BRCC36 deubiquitinating enzyme (DUB) to polyubiquitin structures at DNA double-strand breaks (DSBs). "
4.	Dehydration (Water Stress) 02/01/2008 - "Induction of a polyubiquitin gene promoter by dehydration stresses in transformed rice cells." 02/01/2008 - "The expression of the maize polyubiquitin gene promoter UBI1 in rice cells has been used to study the involvement of ubiquitin in cell protection responses to dehydration caused by osmotic, saline or freezing stress. "
5.	Neoplasms (Cancer) 01/01/2018 - "It is the first documented OTU DUB that preferably disassembles Lys11-linked polyubiquitin chains and has been shown to regulate multiple cellular events including immune signaling, cell survival and tumor progression. " 02/01/2007 - "The breast and ovarian tumor suppressor BRCA1 catalyzes untraditional polyubiquitin chains that could be a signal for processes other than proteolysis. " 10/19/2017 - "A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-κB signaling, cell death, inflammation, immunity, and cancer. " 01/01/2017 - "Here we discuss the activity and polyubiquitin chain-type specificity of CYLD, A20 and OTULIN, their specific role in NF-κB signaling and cell death, the molecular mechanisms that regulate their activity, their role in immune homeostasis and the association of defects in their activity with inflammation, autoimmunity and cancer." 01/01/2019 - "The tumor suppressor CYLD is a deubiquitinating enzyme that suppresses polyubiquitin-dependent signaling pathways, including the proinflammatory and cell growth-promoting NF-κB pathway. "

Related Drugs and Biologics

1.	Ubiquitin
2.	Proteins (Proteins, Gene)
3.	Deubiquitinating Enzymes
4.	Lysine (L-Lysine)
5.	Ribosomal Proteins (Ribosomal Protein)
6.	Interferon Type I
7.	Carrier Proteins (Binding Protein)
8.	TATA-Box Binding Protein (TATA-Binding Protein)
9.	Peptidylprolyl Isomerase (Prolyl Isomerase)
10.	tributyl phosphate (TBP)

Related Therapies and Procedures

1.	Denervation