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Tumor Suppressor Protein p14ARF (p14ARF)

A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.
Also Known As:
p14ARF; Cdkn2a(p14ARF); p(ARF) Protein; p14(ARF); p14ARF Protein
Networked: 716 relevant articles (7 outcomes, 91 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Rey, Juan A: 10 articles (01/2012 - 03/2003)
2. Gjerset, Ruth A: 9 articles (01/2013 - 10/2002)
3. Rizos, Helen: 9 articles (02/2010 - 02/2003)
4. Kefford, Richard F: 9 articles (02/2010 - 02/2003)
5. Bello, M Josefa: 9 articles (02/2006 - 03/2003)
6. Alonso, M Eva: 7 articles (11/2004 - 03/2003)
7. Gonzalez-Gomez, Pilar: 7 articles (11/2004 - 03/2003)
8. Tannapfel, Andrea: 7 articles (08/2004 - 02/2002)
9. Shimada, Keiji: 6 articles (01/2008 - 04/2002)
10. Ishida, Eiwa: 6 articles (01/2008 - 04/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Squamous Cell Carcinoma (Epidermoid Carcinoma)
3. Mesothelioma
4. Neoplasm Metastasis (Metastasis)
5. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

Related Drugs and Biologics

1. Complementary DNA (cDNA)
2. Cyclin-Dependent Kinase Inhibitor p16
3. Messenger RNA (mRNA)
4. Proteins (Proteins, Gene)
5. DNA (Deoxyribonucleic Acid)
6. Telomerase (Telomerase Reverse Transcriptase)
7. beta Catenin
8. Cadherins (E-Cadherin)
9. Tumor Suppressor Proteins (Proteins, Tumor Suppressor)
10. Proto-Oncogene Proteins c-mdm2

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Ligation
3. Mediterranean Diet
4. Radiotherapy
5. Prostatectomy (Retropubic Prostatectomy)