|1.||Dickson, Dennis W: 38 articles (12/2012 - 04/2003)|
|2.||Trojanowski, John Q: 31 articles (03/2012 - 12/2002)|
|3.||Lee, Virginia M-Y: 29 articles (04/2010 - 12/2002)|
|4.||Neumann, Manuela: 25 articles (07/2010 - 06/2005)|
|5.||Arai, Tetsuaki: 24 articles (02/2015 - 07/2002)|
|6.||Akiyama, Haruhiko: 23 articles (02/2015 - 07/2002)|
|7.||Rademakers, Rosa: 23 articles (04/2013 - 07/2005)|
|8.||Hasegawa, Masato: 22 articles (02/2015 - 05/2003)|
|9.||Mackenzie, Ian R A: 20 articles (11/2011 - 02/2003)|
|10.||Patterson, Cam: 19 articles (09/2015 - 10/2004)|
03/01/2015 - "Ubiquitin-specific peptidase 22 (USP22) was recently identified as a new tumor cell marker, and previous studies demonstrated its expression in a variety of tumors and its correlation with tumor progression. "
01/01/2014 - "Our previous study proved that over-expression of ubiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, was associated with favorable prognosis in NSCLC patients and promoted tumor cells proliferation. "
07/15/2013 - "Two recently published studies report the ubiquitin-dependent degradation of Cdt2 via the cullin 1-RING ubiquitin ligase (CRL1) in association with the substrate specificity factor and tumor suppressor FBXO11 (CRL1 (FBXO11)). "
11/15/2010 - "In summary, we have discovered a novel APC2 inhibitory activity of FBG1 independent from its function as ubiquitin ligase, providing the basis for future studies of FBG1 in aging and cancer."
09/01/2009 - "The first study (560 cases and 1122 controls) was to define the contribution of cell cycle and ubiquitin ligase genes to cancer susceptibility. "
|2.||Muscular Atrophy (Muscle Atrophy)
01/01/2005 - "MURF-1, the only family member expressed throughout development, has been implicated in several studies as an ubiquitin ligase that is upregulated in response to multiple stimuli during muscle atrophy. "
07/01/2000 - "The aim of the present study is to compare the cross-section area (CSA) and the immunoreactivity of conjugated-ubiquitin in soleus extrafusal and intrafusal fibers after simulated-microgravity in order to demonstrate the role of muscle spindle in muscle atrophy induced by simulated microgravity."
06/01/2015 - "The expression of ubiquitin-specific peptidase 19 (USP19) is upregulated during muscle atrophy and by E₂-activated ERα. "
02/13/2015 - "HDAC6 is able to interact with MAFbx, a key ubiquitin ligase involved in muscle atrophy. "
01/01/2013 - "We have reported that Cbl-b ubiquitin ligase is a master regulator of unloading-associated muscle atrophy. "
|3.||Neurodegenerative Diseases (Neurodegenerative Disease)
01/01/2015 - "These studies represent the first protein expression profiling of a ubiquitin-conjugating enzyme in the brain and support the notion that deficits in protein degradation and proteostasis associated with neurodegenerative diseases may be, in part, attributable to age-dependent reductions in the enzymatic machinery of the UPS."
06/01/2008 - "A role for ubiquitin in the pathogenesis of human diseases was first suggested some two decades ago, from studies that localized the protein to intracellular protein aggregates, which are a feature of the major human neurodegenerative disorders. "
08/01/1990 - "Morphological studies using immunohistochemistry to localize ubiquitin protein conjugates have revealed that ubiquitin is a component of many of the filamentous inclusion bodies characteristic of neurodegenerative diseases, suggesting activation of a common neuronal response in this type of disease process. "
12/01/2015 - "Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease."
09/01/2015 - "p62/SQSTM1 (p62) is highly involved with intracellular proteolysis and is a component of ubiquitin-positive inclusions in various neurodegenerative disorders. "
|4.||Frontotemporal Lobar Degeneration (Semantic Dementia)
02/01/2007 - "The purpose of this study was to determine whether there were distinctive clinical and neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with PGRN mutations. "
11/07/2014 - "In conclusion, our LC-MS/MS method may facilitate ubiquitin determination to a broader community and might help to discriminate AD, CJD, and FTLD patients. "
12/15/2013 - "Only one out of nine FTLD-FUS cases showed pathology that corresponds to atypical FTLD with ubiquitin-positive inclusions (aFTLD-U). "
01/01/2013 - "However, test measures did not discriminate between FTLD-tau and FTLD-ubiquitin. "
01/01/2013 - "Frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) is one of the most common pathological findings associated with the clinical FTLD syndromes. "
08/05/2011 - "An immunohistochemical study in a large series of HCC/cirrhosis sampled on tissue microarray supported that ubiquitin was overexpressed in HCC. "
09/01/2010 - "Collectively, these data suggest that Trps1 haploinsufficiency enhances TGF-beta1-induced EMT and tubulointerstitial fibrosis by modulating the amount of Smad7 through Arkadia/ubiquitin-mediated degradation."
06/01/2009 - "Using the Cre-loxP mediated gene targeting of HIF-1alpha or VHL which acts as a ubiquitin ligase to promote degradation of HIF-1alpha, we showed that HIF-1alpha plays a key role in the progression of renal fibrosis. "
05/01/2006 - "Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury."
06/08/2004 - "Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice."
|1.||Proteasome Endopeptidase Complex (Proteasome)
|2.||Proteins (Proteins, Gene)
|4.||protein TDP-43 (TDP-43)
|5.||Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
|6.||Messenger RNA (mRNA)
|8.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|2.||Drug Therapy (Chemotherapy)
|3.||Homologous Transplantation (Allograft)