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Ubiquitin

A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Also Known As:
APF-1; ATP-Dependent Proteolysis Factor 1; HMG-20; High Mobility Protein 20; Ubiquitin, Human; ATP Dependent Proteolysis Factor 1; Human Ubiquitin
Networked: 5085 relevant articles (48 outcomes, 410 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Dickson, Dennis W: 38 articles (12/2012 - 04/2003)
2. Trojanowski, John Q: 31 articles (03/2012 - 12/2002)
3. Lee, Virginia M-Y: 29 articles (04/2010 - 12/2002)
4. Neumann, Manuela: 25 articles (07/2010 - 06/2005)
5. Arai, Tetsuaki: 24 articles (02/2015 - 07/2002)
6. Akiyama, Haruhiko: 23 articles (02/2015 - 07/2002)
7. Rademakers, Rosa: 23 articles (04/2013 - 07/2005)
8. Hasegawa, Masato: 22 articles (02/2015 - 05/2003)
9. Mackenzie, Ian R A: 20 articles (11/2011 - 02/2003)
10. Patterson, Cam: 19 articles (09/2015 - 10/2004)

Related Diseases

1. Neoplasms (Cancer)
2. Muscular Atrophy (Muscle Atrophy)
3. Neurodegenerative Diseases (Neurodegenerative Disease)
4. Frontotemporal Lobar Degeneration (Semantic Dementia)
5. Fibrosis (Cirrhosis)

Related Drugs and Biologics

1. Proteasome Endopeptidase Complex (Proteasome)
2. Proteins (Proteins, Gene)
3. Ligases
4. protein TDP-43 (TDP-43)
5. Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
6. Messenger RNA (mRNA)
7. polyglutamine
8. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9. Calpain
10. Dexamethasone (Maxidex)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Homologous Transplantation (Allograft)
4. Denervation
5. Resuscitation