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Phosphofructokinase-2 (Phosphofructokinase 2)

An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
Also Known As:
Phosphofructokinase 2; 6-PF-2-K-Fru-2,6-P(2)ase; 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase; 6PF2K; ATP-D-Fructose-6-phosphate 2-phosphotransferase; F Kinase-F-bisphosphatase; Fru-6-P,2-kinase; Fru-kinase-Fru-bisphosphatase; Fructose 2,6-bisphosphatase; Fructose-2,6-bisphosphate 2-phosphatase; Fructose-6-P,2-kinase; Fructose-6-phosphate,2-kinase; Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase; fructose-2,6-diphosphatase; 6-Phosphofructo-2-kinase; 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase; Fructose-2,6-bisphosphatase
Networked: 37 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Telang, Sucheta: 4 articles (07/2015 - 01/2008)
2. Chesney, Jason: 4 articles (07/2015 - 01/2008)
3. Trent, John O: 3 articles (07/2015 - 01/2008)
4. Zhang, Weiyu: 2 articles (06/2012 - 02/2010)
5. Li, Honggui: 2 articles (06/2012 - 02/2010)
6. Huo, Yuqing: 2 articles (06/2012 - 02/2010)
7. Chapkin, Robert S: 2 articles (06/2012 - 02/2010)
8. Wang, Huan: 2 articles (06/2012 - 02/2010)
9. Guo, Xin: 2 articles (06/2012 - 02/2010)
10. Wu, Chaodong: 2 articles (06/2012 - 02/2010)

Related Diseases

1. Insulin Resistance
2. Sepsis (Septicemia)
3. Anoxia (Hypoxia)
4. Starvation
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. fructose 2,6-diphosphate
2. Phosphofructokinase-1 (Phosphofructokinase 1)
3. Glucose (Dextrose)
4. Phosphofructokinase-2 (Phosphofructokinase 2)
5. AMP-Activated Protein Kinases
6. Messenger RNA (mRNA)
7. Phosphotransferases (Kinase)
8. Insulin (Novolin)
9. Cyclic AMP (AMP, Cyclic)
10. Phosphoenolpyruvate