Vacuolar Proton-Translocating ATPases (V-Type ATPase)

Proton-translocating ATPases that are involved in acidification of a variety of intracellular compartments.

Also Known As:

V-Type ATPase; Vacuolar ATPase; Lysosomal F(1)F(0) ATPase; Lysosomal Proton-Translocating ATPases; Vacuolar F(1)F(0) ATPase; Vacuolar F(1)F(0) ATPases; Vacuolar H+-ATPase; Vacuolar Membrane H(+)-ATPase; ATPase, V-Type; ATPase, Vacuolar; ATPases, Lysosomal Proton-Translocating; H+-ATPase, Vacuolar; Lysosomal Proton Translocating ATPases; Proton-Translocating ATPases, Lysosomal; V Type ATPase; Vacuolar H+ ATPase

Networked: 290 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Beaman, Kenneth D: 7 articles (09/2018 - 02/2015)
2.	Katara, Gajendra K: 7 articles (09/2018 - 02/2015)
3.	Pei, Fei: 7 articles (01/2018 - 07/2010)
4.	Wagner, Carsten A: 7 articles (01/2018 - 12/2003)
5.	Kulshrestha, Arpita: 6 articles (09/2018 - 02/2015)
6.	Gilman-Sachs, Alice: 6 articles (01/2018 - 03/2007)
7.	You, Jiangfeng: 6 articles (01/2018 - 07/2012)
8.	Xu, Xiaoyan: 5 articles (01/2018 - 07/2012)
9.	Manolson, Morris F: 5 articles (05/2014 - 11/2010)
10.	Klionsky, Daniel J: 4 articles (05/2022 - 01/2019)

Related Diseases

1.	Infections 05/01/2014 - "Inhibition by cellular vacuolar ATPase impairs human papillomavirus uncoating and infection." 01/01/2013 - "Involvement of MoVMA11, a Putative Vacuolar ATPase c' Subunit, in Vacuolar Acidification and Infection-Related Morphogenesis of Magnaporthe oryzae." 10/01/2011 - "Regulation of chlamydial infection by host autophagy and vacuolar ATPase-bearing organelles." 01/01/2018 - "Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection." 09/01/2011 - "The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections."
2.	Glioma (Gliomas) 10/02/2007 - "Protective effects of vacuolar H+ -ATPase c on hydrogen peroxide-induced cell death in C6 glioma cells." 01/01/2022 - "Identification of a five-gene signature deriving from the vacuolar ATPase (V-ATPase) sub-classifies gliomas and decides prognoses and immune microenvironment alterations." 05/01/2003 - "Likewise, another V-type ATPase inhibitor, bafilomycinA1 facilitated GDNF release from C6, U87MG and T98G glioma cells, in a concentration-dependent manner. " 01/01/1994 - "The aim of this work was to examine the effects of changes in external K+ concentration (Ko) around its physiological value, of various K+ channels blockers, including internal Cs+, of vacuolar H(+)-ATPase inhibitors and of the protonophore CCCP on the resting potential and the voltage-dependent K+ current of differentiated neuroblastoma x glioma hybrid NG108-15 cells using the whole-cell patch-clamp technique. " 05/01/2003 - "In search of finding a compound which promotes GDNF secretion, we found that concanamycin A (ConA), a vacuolar ATPase (V-type ATPase) inhibitor purified from Streptomyces diastatochromogens, enhanced GDNF secretion from glioma cells. "
3.	Carcinoma (Carcinomatosis) 01/01/2008 - "In conclusion, the available results show for the first time that a vacuolar H(+)-ATPase inhibitor is effective in modulation of the metastatic behavior of a lung carcinoma, supporting its potential therapeutic interest as a novel treatment approach." 03/01/2014 - "[LASS2/TMSG1 gene silencing promotes the invasiveness and metastatic of human prostatic carcinoma cells through increase in vacuolar ATPase activity]." 08/01/2009 - "Biological effects of a new vacuolar-H,-ATPase inhibitor in colon carcinoma cell lines." 01/01/2016 - "Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells."
4.	Fibrosis (Cirrhosis) 01/01/2018 - "Acidic organelles mediate TGF-β1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells." 01/01/2020 - "Metformin, as a strong base, a potential regulator of Vacuolar ATPase (V-ATPase) and endosomal Na+/H+ exchangers (eNHEs), additionally a regenerative agent for lung fibrosis, seems to be beneficial for patients in acute, chronic and recovery phases of COVID-19."
5.	COVID-19 01/01/2020 - "Metformin, as a strong base, a potential regulator of Vacuolar ATPase (V-ATPase) and endosomal Na+/H+ exchangers (eNHEs), additionally a regenerative agent for lung fibrosis, seems to be beneficial for patients in acute, chronic and recovery phases of COVID-19." 08/16/2022 - "We found that the expressions of both vacuolar-ATPase (V-ATPase) and calprotectin (S100A8/S100A9) increased in SARS-CoV-2 infection, by analyzing single-cell RNA sequencing (bronchoalveolar lavage fluid), bulk-RNA sequencing (A549, lung tissue, NHBE), and proteomics (lung tissue), respectively. "

Related Drugs and Biologics

1.	Adenosine Triphosphatases (ATPase)
2.	Hydrogen Peroxide (Hydroperoxide)
3.	Metformin (Glucophage)
4.	Antiviral Agents (Antivirals)
5.	Protons (Proton)
6.	Acids
7.	Proton Pumps (Proton Pump)
8.	bafilomycin A1
9.	Enzymes
10.	Cathepsin K

Related Therapies and Procedures

1.	Caloric Restriction
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)