Muscle Type Phosphofructokinase-1 (Phosphofructokinase 1, Muscle Type)
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In humans, PHOSPHOFRUCTOKINASE-1 in muscle exists as the homotetramer of M subunits. Defects in this muscle enzyme cause GLYCOGEN STORAGE DISEASE TYPE VII, also known as Tarui's disease.
Also Known As:
Phosphofructokinase 1, Muscle Type; Phosphofructokinase-1, Muscle Type; Phosphofructo-1-kinase Isozyme A; 6-Phosphofructokinase, Muscle Type
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