Muscle Type Phosphofructokinase-1 (Phosphofructokinase 1, Muscle Type)

An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In humans, PHOSPHOFRUCTOKINASE-1 in muscle exists as the homotetramer of M subunits. Defects in this muscle enzyme cause GLYCOGEN STORAGE DISEASE TYPE VII, also known as Tarui's disease.

Also Known As:

Phosphofructokinase 1, Muscle Type; Phosphofructokinase-1, Muscle Type; Phosphofructo-1-kinase Isozyme A; 6-Phosphofructokinase, Muscle Type

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Fructokinases
        Phosphofructokinases: 536
        Phosphofructokinase-1: 87
        Muscle Type Phosphofructokinase-1: 1
        human PFKM protein
        type M phosphofructokinase-1 subunit

Experts

1.	Luo, Chun-Xia: 1 article (02/2011)
2.	Zhu, Dong-Ya: 1 article (02/2011)

Related Diseases

Lymphoid Leukemia

02/01/2011 - "There are primarily 9 nNOS-interacting proteins, including post-synaptic density protein 95 (PSD95), clathrin assembly lymphoid leukemia (CALM), calcium/calmodulin-dependent protein kinase II alpha (CAMKIIA), Disks large homolog 4 (DLG4), DLG2, 6-phosphofructokinase, muscle type (PFK-M), carboxy-terminal PDZ ligand of nNOS (CAPON) protein, syntrophin and dynein light chain (LC). "

Related Drugs and Biologics

1.	Calcium-Calmodulin-Dependent Protein Kinases
2.	Proteins (Proteins, Gene)
3.	Ligands
4.	Dyneins (Dynein)
5.	Clathrin
6.	syntrophin