Vitamin B 6

VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.

Also Known As:

Networked: 1882 relevant articles (132 outcomes, 319 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Selhub, Jacob: 20 articles (01/2017 - 07/2002)
2.	Kato, Norihisa: 18 articles (03/2022 - 05/2003)
3.	Midttun, Øivind: 18 articles (01/2022 - 06/2010)
4.	Ueland, Per Magne: 15 articles (01/2022 - 09/2004)
5.	Yanaka, Noriyuki: 14 articles (03/2022 - 07/2005)
6.	Ulvik, Arve: 13 articles (01/2022 - 01/2015)
7.	Ueland, Per M: 11 articles (01/2022 - 05/2009)
8.	Giovannucci, Edward: 11 articles (01/2018 - 05/2005)
9.	Hankey, Graeme J: 9 articles (06/2018 - 06/2008)
10.	Johansson, Mattias: 8 articles (01/2022 - 05/2009)

Related Diseases

1.	Nausea 12/01/2009 - "In the ginger group, 29/35 women reported an improvement in nausea symptoms, compared with 23/34 women in the vitamin B6 group (p = 0.52). " 01/01/2013 - "In a clinical trial in health centers of Qazvin University of Medical Sciences from November 2010 to February 2011 on pregnant mothers, the effects of vitamin B6 (40 mg twice daily) and ginger (250 mg four times daily) were evaluated in treatment of pregnancy nausea. " 01/01/2013 - "Comparing the effectiveness of vitamin B6 (40 mg twice daily) and ginger (250 mg four times daily) in treatment of pregnancy nausea. " 09/01/2003 - "The ginger and vitamin B6 significantly reduced the nausea scores from 5.0 (SD, 1.99) to 3.6 (SD, 2.48) and 5.3 (SD, 2.08) to 3.3 (SD, 2.07) respectively, with p < 0.001. " 07/01/1991 - "Twelve of 31 patients in the vitamin B6 group had a pre-treatment nausea score greater than 7 (severe) (mean 8.2 +/- 0.8), as did ten of 28 patients in the placebo group (mean 8.7 +/- 0.9) (not significant). "
2.	Vomiting 11/01/2020 - "In the USA, Canada and Australia, vitamin B6 is officially recommended in the treatment of mild to moderate pregnancy sickness and vomiting. " 11/01/2018 - "Of these interventions, ginger and vitamin B6 were also associated with better vomiting control and less incidence of adverse events. " 10/01/2018 - "(p < .001, p = .012, and p = .03 for ginger, vitamin B6, and placebo, respectively.) Also total score of Rhodes questionnaire for vomiting was decreased in three groups (p = .03 for ginger, p = .02 for B6, and p = .04 for placebo). " 01/01/2013 - "Vomiting was more reduced in vitamin B6 group; however, this reduction was not statistically significant. " 09/01/2003 - "The ginger and vitamin B6 also significantly reduced the number of vomiting episodes from 1.9 (2.06) to 1.2 (1.75) and 1.7 (1.81) to 1.2 (1.50) respectively, with p < 0.01. "
3.	Vitamin B 6 Deficiency (Pyridoxine Deficiency) 01/01/1991 - "The present study indicates that vitamin B6 deficiency is prevalent in CDC stage III HIV-1-infected subjects, despite adequate dietary vitamin B6 intake. " 11/01/1977 - "Two metabolic trials using early-weaned piglets were performed to find out whether highly vitamin B6 deficient prest,rter- or starter feeds (0.4 mg vitamin B6/Kg) would affect the excretion and retention of Ca, P, Mg, K and Na as compared with pair-fed control animals given 6.5 mg B6/Kg. The depleted animals showing typical vitamin B6 deficiency symptoms in the course of the trials, were found to excrete in the feces somewhat smaller amounts of minerals during both metabolic periods. " 10/28/2023 - "Among UK adults, the median intakes of total population of dietary vitamin B6 met the reference nutrient intake and median plasma PLP concentrations were above the cut-off of vitamin B6 deficiency; however, we found an association between reduction in vitamin B6 intake and plasma PLP concentration and age group (P < 0·001). " 10/01/2023 - "He was found to have pyridoxine deficiency and had full resolution of symptoms shortly after the administration of vitamin B6 supplementation. " 10/01/2023 - "Vitamin B6 deficiency reduces memory in dams and their offspring, suggesting the importance of vitamin B6 for both brain function and development. "
4.	Neoplasms (Cancer) 07/01/1996 - "A comparison of the control, remission and other ailments groups with the cancer patient groups shows them to be significantly different (P < 0.00001) and strongly supports the use of the novel vitamin B6 conjugate metabolite for detection of human cancers." 07/01/1996 - "The results show that the level of the vitamin B6 metabolite in the blood of cancer patients is up to 4x or higher than levels seen in the blood of normal volunteers, patients in remission or patients with other diseases. " 04/01/2012 - "This study provides an insight into the genomic activities of dietary vitamin B6 that may be protective against colon tumor development." 08/15/1996 - "The results show that the level of the vitamin B6 conjugate in the circulation of control subjects, cancer patients in remission, and patients with other diseases was only minimal. " 01/01/2021 - "A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study."
5.	Autistic Disorder (Autism) 06/01/2018 - "Why is vitamin B6 effective in alleviating the symptoms of autism?" 03/01/2006 - "Previous studies reported positive results with the use of Mg-vitamin B6 in autism. " 01/01/2006 - "This may explain the many published studies of benefits of high-dose vitamin B6 supplementation in some children and adults with autism." 01/01/2006 - "(This includes the data from 24 children with autism from our previous study.) A microbiologic assay was used to measure the level of total vitamin B6 (including phosphorylated and unphosphorylated forms), in a blinded fashion. " 01/01/2006 - "There have been many studies of the effect of high-dose supplementation of vitamin B6 on children and adults with autism, with all but one reporting benefits. "

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Pyridoxine (Pyridoxin)
3.	Vitamin B 12 (Cyanocobalamin)
4.	Magnesium
5.	Antipsychotic Agents (Antipsychotics)
6.	Homocysteine
7.	Zinc
8.	Vitamins
9.	Ascorbic Acid (Vitamin C)
10.	Niacin (Nicotinic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Secondary Prevention
4.	Aftercare (After-Treatment)
5.	Injections