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Ventricular Myosins

Isoforms of MYOSIN TYPE II, specifically found in the ventricular muscle of the HEART. Defects in the genes encoding ventricular myosins result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Also Known As:
Cardiac alpha-Myosin; Cardiac beta-Myosin; Myosin V1; Myosin V2; Myosin V3; Myosin, Ventricular; Ventricular Cardiac alpha-Myosin; Ventricular Cardiac beta-Myosin; Ventricular Isomyosins; Ventricular Myosin; Ventricular alpha, beta- Myosin; Ventricular alpha-Myosin; Ventricular beta-Myosin; alpha-Myosin; beta-Myosin; Cardiac alpha Myosin; Cardiac alpha-Myosin, Ventricular; Cardiac beta Myosin; Cardiac beta-Myosin, Ventricular; Isomyosins, Ventricular; Myosins, Ventricular; Ventricular Cardiac alpha Myosin; Ventricular Cardiac beta Myosin; Ventricular alpha Myosin; Ventricular alpha, beta Myosin; Ventricular beta Myosin; alpha Myosin; alpha-Myosin, Cardiac; alpha-Myosin, Ventricular; alpha-Myosin, Ventricular Cardiac; beta Myosin; beta-Myosin, Cardiac; beta-Myosin, Ventricular; beta-Myosin, Ventricular Cardiac
Networked: 514 relevant articles (6 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Szczesna-Cordary, Danuta: 12 articles (01/2021 - 08/2005)
2. Leinwand, Leslie A: 8 articles (07/2010 - 06/2002)
3. Kazmierczak, Katarzyna: 7 articles (01/2021 - 03/2009)
4. Ackerman, Michael J: 6 articles (10/2020 - 06/2002)
5. Eriksson, Urs: 6 articles (10/2009 - 07/2002)
6. Liang, Jingsheng: 5 articles (01/2021 - 08/2013)
7. Ommen, Steve R: 5 articles (10/2020 - 06/2002)
8. Robbins, Jeffrey: 5 articles (02/2010 - 06/2002)
9. Huang, Wenrui: 4 articles (01/2016 - 02/2012)
10. Muthu, Priya: 4 articles (08/2013 - 05/2010)

Related Diseases

1. Hypertrophy
2. Cardiomegaly (Heart Hypertrophy)
3. Fibrosis (Cirrhosis)
4. Infarction (Infarctions)
07/01/1987 - "Thus ventricular myosin light chains were found in pressure overloaded atria and atrial light chains have also been identified in the infarct ventricle of the human heart. "
11/04/2008 - "Constitutive overexpression of iNOS in transgenic mice (alpha-myosin heavy chain promoter) did not induce contractile dysfunction and did not affect mitochondrial respiration or biogenesis, but it profoundly decreased infarct size in mice subjected to 30 minutes of coronary occlusion and 24 hours of reperfusion. "
01/01/1995 - "The serum level of human ventricular myosin light chains 1 and 2 (HVMLC1 and HVMLC2) in healthy subjects was of 6-10 ng/ml. Sensitivity of the assay was 10 ng/ml, and the working range was 10-100 ng/ml. In all AMI patients the HVMLC1 serum level exceeded 2-3 times the reference range within the first 24 hours after the onset of chest pain, the mean (+/- ISD) peak concentration was of 45.7 (+/- 13.6) ng/ml (simple AMI) and 64.22 (+/- 18.5 ng/ml) (severe AMI) 48 hours after infarction and it remained significantly higher than the normal value for another 7-10 days after the onset of infarction. "
05/31/1989 - "The quantitation of human ventricular myosin light chain 1 in serum after myocardial necrosis and infarction."
04/01/2001 - "beta-Myosin heavy chain levels were markedly reduced in peri-infarct regions of the left ventricular free wall, septum, and right ventricle in plicated rats at level 4, whereas myosin light chain-2v levels were reduced at levels 2 and 4 in the left ventricular free wall and at level 4 in the right ventricle. "
5. Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)

Related Drugs and Biologics

1. Atrial Natriuretic Factor (ANF)
2. Proteins (Proteins, Gene)
3. Brain Natriuretic Peptide (Natrecor)
4. Reactive Oxygen Species (Oxygen Radicals)
5. Glycogen Synthase Kinase 3 beta
6. Dobutamine
7. Simvastatin (Zocor)
8. Factor VIII (Coagulation Factor VIII)
9. Bromodeoxyuridine (BrdU)
10. dioscin

Related Therapies and Procedures

1. Transplantation
2. Caloric Restriction
3. Ligation
4. Drug Therapy (Chemotherapy)
5. Therapeutics