|1.||Marra, Ersilia: 4 articles (05/2011 - 06/2005)|
|2.||Greco, Margherita: 4 articles (05/2011 - 06/2005)|
|3.||Moro, Loredana: 4 articles (05/2011 - 06/2005)|
|4.||Arbini, Arnaldo A: 4 articles (05/2011 - 06/2005)|
|5.||Arnold, Katrin: 3 articles (11/2007 - 07/2004)|
|6.||Savelyeva, Larissa: 3 articles (11/2007 - 07/2004)|
|7.||Klaes, Ruediger: 2 articles (06/2014 - 09/2003)|
|8.||Yao, Jorge L: 2 articles (05/2011 - 03/2008)|
|9.||Taniguchi, Toshiyasu: 2 articles (08/2009 - 01/2009)|
|10.||Swisher, Elizabeth M: 2 articles (08/2009 - 01/2009)|
08/15/2009 - "Here, we show functional significance of restoration of BRCA2 protein by secondary BRCA2 mutations in acquired drug resistance of BRCA2-mutated ovarian carcinoma. "
08/15/2009 - "Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma."
05/15/2000 - "BRCA2 protein expression in sporadic breast carcinoma with or without allelic loss of BRCA2."
03/01/2008 - "Here, on prostate adenocarcinoma specimens from 80 patients, we demonstrate that BRCA2 protein is lost in carcinoma cells compared to normal and hyperplastic prostate epithelium. "
06/10/2005 - "By using normal and prostate carcinoma cell lines, we demonstrated that although normal cells transiently increase BRCA2 protein levels when adhering to the ECM protein collagen type I (COL1), carcinoma cells exhibit a significant reduction in BRCA2 protein. "
|2.||Breast Neoplasms (Breast Cancer)
01/01/2009 - "Using the breast-cancer-associated BRCA2 protein as a model, the principle of sequence uniqueness is defined as the rationale for a pharmacological platform that might yield improved results in both patient survival and quality of life."
08/10/2009 - "Preclinical as well as a few small retrospective, neoadjuvant studies suggest that breast cancer (cells) without functional BRCA1 or BRCA2 protein have an increased sensitivity to some chemotherapeutic agents causing double-strand DNA breaks. "
01/01/2015 - "On the other hand, the expression of BRCA2 protein was moderate or low in breast cancer cases and its overall distribution did not show significant difference when compared with controls. "
12/02/2014 - "The aberrant expressions of BRCA1 and BRCA2 protein plays a major role in the occurrence and progression of sporadic breast cancer."
12/02/2014 - "The expression of BRCA1 had no obvious relation with BRCA2 protein in breast cancer tissues (r = 0.673, P > 0.05). "
09/10/2011 - "This study focused on the poorly studied linker region of the cancer-associated BRCA2 protein encoded by exons twelve through fourteen of BRCA2. "
04/01/2008 - "In order to study the role of BRCA2 protein in homologous recombination repair and radio-sensitization, we utilized RNA interference strategy in vitro and in vivo with human tumor cells. "
01/01/2015 - "Our results demonstrate in a subset of cases that decline in BRCA1 expression that may be associated with potentially compensatory increase in BRCA2 protein, which may depend on tumor grade as well as menopausal status."
12/01/2013 - "In this review, I will address current biochemical data concerning the BRCA2 protein and highlight unanswered questions regarding BRCA2 function in homologous recombination and cancer. "
04/01/2012 - "However, how BRCA2 protein expressions are suppressed in these tumors remains unknown. "
|4.||Chromosomal Instability (Chromosome Stability)
07/08/2004 - "The BRCA2 protein is implicated in the maintenance of chromosome stability through its essential function in double-strand DNA repair and recombination. "
03/01/2014 - "Insights into this role have emerged from studies on the tumour suppressor BRCA2, whose inactivation in human cancers causes chromosomal instability through the loss of essential functions of the BRCA2 protein in the normal mechanisms responsible for the replication, repair and segregation of DNA during cell division. "
06/01/2010 - "The BRCA2 protein interacts via the BRC (breast cancer) domain with RAD51, an essential component of the cellular machinery for the maintenance of genome stability and double strand-breaks repair. "
11/08/2006 - "These results are indicative of a haploinsufficiency phenotype in BRCA2+/- cells, suggesting that reduced amounts of functional BRCA2 protein in BRCA2+/- carriers are insufficient for an efficient repair of DNA double strand breaks, a condition that could contribute to the impairment of genomic stability."
11/08/2006 - "The BRCA2 protein is involved in the maintenance of genomic stability through its key role in homologous recombination repair of DNA double strand breaks. "
12/01/2002 - "The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA."
|1.||Collagen Type I (Type I Collagen)
|2.||Mitochondrial DNA (mtDNA)
|3.||DNA (Deoxyribonucleic Acid)
|6.||Single-Stranded DNA (DNA, Single Stranded)
|7.||Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
|9.||Proteasome Endopeptidase Complex (Proteasome)
|1.||Drug Therapy (Chemotherapy)