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BRCA2 Protein

A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)
Also Known As:
BRCA2 Gene Product; Breast Cancer 2 Protein; FANCD1 Protein; Fanconi Anemia Group D1 Complementing Protein; Fanconi Anemia Group D1 Protein; Breast Cancer 2 Gene Product; Fanconi Anemia Complementation Group D1 Protein
Networked: 47 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Marra, Ersilia: 4 articles (05/2011 - 06/2005)
2. Greco, Margherita: 4 articles (05/2011 - 06/2005)
3. Moro, Loredana: 4 articles (05/2011 - 06/2005)
4. Arbini, Arnaldo A: 4 articles (05/2011 - 06/2005)
5. Arnold, Katrin: 3 articles (11/2007 - 07/2004)
6. Savelyeva, Larissa: 3 articles (11/2007 - 07/2004)
7. Klaes, Ruediger: 2 articles (06/2014 - 09/2003)
8. Yao, Jorge L: 2 articles (05/2011 - 03/2008)
9. Taniguchi, Toshiyasu: 2 articles (08/2009 - 01/2009)
10. Swisher, Elizabeth M: 2 articles (08/2009 - 01/2009)

Related Diseases

1. Carcinoma (Carcinomatosis)
2. Breast Neoplasms (Breast Cancer)
3. Neoplasms (Cancer)
4. Chromosomal Instability (Chromosome Stability)
5. Genomic Instability

Related Drugs and Biologics

1. Collagen Type I (Type I Collagen)
2. Mitochondrial DNA (mtDNA)
3. DNA (Deoxyribonucleic Acid)
4. BRCA1 Protein
5. Phosphotransferases (Kinase)
6. Single-Stranded DNA (DNA, Single Stranded)
7. Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
8. Rad51 Recombinase
9. Proteasome Endopeptidase Complex (Proteasome)
10. Ubiquitin

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)