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Inwardly Rectifying Potassium Channels (Inward Rectifier Potassium Channels)

Potassium channels where the flow of K+ ions into the cell is greater than the outward flow.
Also Known As:
Inward Rectifier Potassium Channels; Potassium Channels, Inwardly Rectifying; IRK1 Channel; Inward Rectifier K+ Channel; Inward Rectifier K+ Channels; Inward Rectifier Potassium Channel; Inwardly Rectifying Postassium Channels; Inwardly Rectifying Potassium Channel; K+ Channels, Inwardly Rectifying; Potassium Channel, Inwardly Rectifying; Channel, IRK1
Networked: 90 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Jalife, José: 4 articles (06/2012 - 12/2006)
2. Plummer, Howard K: 4 articles (01/2008 - 12/2004)
3. Berenfeld, Omer: 3 articles (06/2012 - 12/2006)
4. Dhar, Madhu S: 3 articles (01/2008 - 01/2005)
5. Kalifa, Jérôme: 2 articles (06/2012 - 12/2006)
6. Noujaim, Sami F: 2 articles (06/2012 - 11/2010)
7. Calvo, Conrado J: 2 articles (06/2012 - 11/2010)
8. Ellard, Sian: 2 articles (01/2008 - 03/2006)
9. Jacobowitz, David M: 2 articles (07/2006 - 02/2006)
10. Siarey, Richard J: 2 articles (07/2006 - 02/2006)

Related Diseases

1. Paralysis (Palsy)
01/15/2015 - "Andersen's syndrome (AS) is a rare and dominantly inherited pathology, linked to the inwardly rectifying potassium channel Kir2.1. AS patients exhibit a triad of symptoms that include periodic paralysis, cardiac dysrhythmia and bone malformations. "
10/01/2010 - "Another recent study indicated that thyrotoxic hypokalaemic periodic paralysis is determined by mutations in a novel gene encoding an inwardly rectifying potassium channel, Kir2.6. Work studying molecular mechanisms indicates that 90% of the known mutations causing hypokalaemic periodic paralysis (HypoPP) result in loss of positively charged arginine residues in the S4 segments of either SCN4A or CACNA1S, possibly creating a gating-pore current that may be important in the pathogenesis of HypoPP. "
08/01/2006 - "Andersen-Tawil syndrome (ATS) is a rare inherited disorder, characterised by periodic paralysis, cardiac dysarrhythmias, and dysmorphic features, and is caused by mutations in the gene KCNJ2, which encodes the inward rectifier potassium channel, Kir2.1. This study sought to analyse KCNJ2 in patients with familial ATS and to determine the functional characteristics of the mutated gene. "
03/01/2006 - "Andersen-Tawil syndrome, a skeletal muscle syndrome associated with periodic paralysis and long QT intervals on the ECG, has been linked to defects in KCNJ2, the gene encoding for the inward rectifier potassium channel (I(K1).) The purpose of this study was to examine the cellular mechanisms underlying the ECG and arrhythmic manifestations of Andersen-Tawil syndrome. "
07/01/2015 - "Loss-of-function mutations of the KCNJ2 gene encoding for the inward rectifier potassium channel subunit Kir2.1 cause Andersen-Tawil Syndrome (ATS), a rare genetic disorder characterised by periodic paralysis, ventricular arrhythmias, and dysmorphic features. "
2. Ischemia
3. Cardiac Arrhythmias (Arrythmia)
4. Obesity
5. Epilepsy (Aura)

Related Drugs and Biologics

1. Andersen Tawil syndrome
2. Adenosine Triphosphate (ATP)
3. Potassium
4. Magnesium
5. Diazoxide (Hyperstat)
6. Arginine (L-Arginine)
7. GTP-Binding Proteins (G-Protein)
8. sulfonylurea receptor
9. Carbon Monoxide
10. Complementary DNA (cDNA)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)