Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)

Potassium channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. The opening of these channels is induced by the membrane depolarization of the ACTION POTENTIAL.

Also Known As:

Voltage-Gated Potassium Channel; Potassium Channel, Voltage-Gated; Potassium Channels, Voltage-Gated; Kv Potassium Channels; Voltage-Gated K+ Channels; K+ Channels, Voltage-Gated; Potassium Channel, Voltage Gated; Potassium Channels, Kv; Potassium Channels, Voltage Gated; Voltage Gated K+ Channels; Voltage Gated Potassium Channel; Voltage Gated Potassium Channels

Networked: 811 relevant articles (15 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Potassium Channels: 2882
        Voltage-Gated Potassium Channels: 811
        potassium channel protein I(sk): 15
        Delayed Rectifier Potassium Channels: 14
        Ether-A-Go-Go Potassium Channels: 8
        Shaker Superfamily of Potassium Channels: 1
        Arabidopsis KAT2 protein
        C elegans KVS-1 protein
        C elegans KVS-4 protein
        Drosophila sei protein
        human KCNE1 protein
        human KCNE2 protein
        human KCNE3 protein
        human KCNE4 protein
        human KCNE5 protein
        human KCNF1 protein
        human KCNG1 protein
        human KCNG3 protein
        human KCNG4 protein
        human KCNQ1OT1 long non-coding RNA
        human KCNS1 protein
        human KCNS2 protein
        human KCNS3 protein
        human KCNV1 protein
        human KCNV2 protein
        human KCTD10 protein
        mouse Kcne1 protein
        mouse Kcne2 protein
        mouse Kcne3 protein
        mouse KCNE4 protein
        mouse Kcng3 protein
        mouse Kcng4 protein
        mouse Kcns1 protein
        mouse Kcns2 protein
        mouse Kcnv1 protein
        mouse Kcnv2 protein
        mouse KCTD10 protein
        mouse Kv6.3 protein
        rat Kcnab2 protein
        rat Kcne1 protein
        rat KCNE2 protein
        rat KCNE3 protein
        rat KCNE4 protein
        rat Kcng3 protein
        rat Kcns1 protein
        Streptomyces coelicolor KcsA protein
        Xenopus KCNE1 protein
        Xenopus Kctd15 protein
        Xenopus Kvbeta2 protein
        zebrafish Kcnb1 protein
        zebrafish kcne1 protein
        zebrafish KCNH3 protein
        zebrafish kcnq1.1 protein
        zebrafish kctd15b protein
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Ion Channels: 6731
        Potassium Channels: 2882
        Voltage-Gated Potassium Channels: 811
        potassium channel protein I(sk): 15
        Delayed Rectifier Potassium Channels: 14
        Ether-A-Go-Go Potassium Channels: 8
        Shaker Superfamily of Potassium Channels: 1
        Arabidopsis KAT2 protein
        C elegans KVS-1 protein
        C elegans KVS-4 protein
        Drosophila sei protein
        human KCNE1 protein
        human KCNE2 protein
        human KCNE3 protein
        human KCNE4 protein
        human KCNE5 protein
        human KCNF1 protein
        human KCNG1 protein
        human KCNG3 protein
        human KCNG4 protein
        human KCNQ1OT1 long non-coding RNA
        human KCNS1 protein
        human KCNS2 protein
        human KCNS3 protein
        human KCNV1 protein
        human KCNV2 protein
        human KCTD10 protein
        mouse Kcne1 protein
        mouse Kcne2 protein
        mouse Kcne3 protein
        mouse KCNE4 protein
        mouse Kcng3 protein
        mouse Kcng4 protein
        mouse Kcns1 protein
        mouse Kcns2 protein
        mouse Kcnv1 protein
        mouse Kcnv2 protein
        mouse KCTD10 protein
        mouse Kv6.3 protein
        rat Kcnab2 protein
        rat Kcne1 protein
        rat KCNE2 protein
        rat KCNE3 protein
        rat KCNE4 protein
        rat Kcng3 protein
        rat Kcns1 protein
        Streptomyces coelicolor KcsA protein
        Xenopus KCNE1 protein
        Xenopus Kctd15 protein
        Xenopus Kvbeta2 protein
        zebrafish Kcnb1 protein
        zebrafish kcne1 protein
        zebrafish KCNH3 protein
        zebrafish kcnq1.1 protein
        zebrafish kctd15b protein
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Potassium Channels: 2882
        Voltage-Gated Potassium Channels: 811
        potassium channel protein I(sk): 15
        Delayed Rectifier Potassium Channels: 14
        Ether-A-Go-Go Potassium Channels: 8
        Shaker Superfamily of Potassium Channels: 1
        Arabidopsis KAT2 protein
        C elegans KVS-1 protein
        C elegans KVS-4 protein
        Drosophila sei protein
        human KCNE1 protein
        human KCNE2 protein
        human KCNE3 protein
        human KCNE4 protein
        human KCNE5 protein
        human KCNF1 protein
        human KCNG1 protein
        human KCNG3 protein
        human KCNG4 protein
        human KCNQ1OT1 long non-coding RNA
        human KCNS1 protein
        human KCNS2 protein
        human KCNS3 protein
        human KCNV1 protein
        human KCNV2 protein
        human KCTD10 protein
        mouse Kcne1 protein
        mouse Kcne2 protein
        mouse Kcne3 protein
        mouse KCNE4 protein
        mouse Kcng3 protein
        mouse Kcng4 protein
        mouse Kcns1 protein
        mouse Kcns2 protein
        mouse Kcnv1 protein
        mouse Kcnv2 protein
        mouse KCTD10 protein
        mouse Kv6.3 protein
        rat Kcnab2 protein
        rat Kcne1 protein
        rat KCNE2 protein
        rat KCNE3 protein
        rat KCNE4 protein
        rat Kcng3 protein
        rat Kcns1 protein
        Streptomyces coelicolor KcsA protein
        Xenopus KCNE1 protein
        Xenopus Kctd15 protein
        Xenopus Kvbeta2 protein
        zebrafish Kcnb1 protein
        zebrafish kcne1 protein
        zebrafish KCNH3 protein
        zebrafish kcnq1.1 protein
        zebrafish kctd15b protein

Experts

1.	Vincent, Angela: 45 articles (12/2018 - 06/2002)
2.	Lang, Bethan: 19 articles (12/2018 - 03/2004)
3.	Pardo, Luis A: 16 articles (01/2022 - 10/2004)
4.	Irani, Sarosh R: 14 articles (01/2019 - 04/2010)
5.	Vincent, A: 12 articles (07/2014 - 04/2000)
6.	McKeon, Andrew: 11 articles (12/2020 - 09/2007)
7.	Pittock, Sean J: 10 articles (12/2020 - 09/2007)
8.	Bien, Christian G: 10 articles (07/2020 - 03/2004)
9.	Watanabe, Osamu: 10 articles (12/2018 - 09/2004)
10.	Waters, Patrick: 10 articles (12/2018 - 09/2010)

Related Diseases

1.	Epilepsy (Aura) 01/01/2021 - "Epilepsy-associated Kv1.1 voltage-gated potassium channel subunits encoded by the Kcna1 gene have traditionally been considered absent in heart, but recent studies reveal they are expressed in cardiomyocytes where they could regulate intrinsic cardiac electrophysiology. " 11/01/2023 - "Pathogenic variants of voltage-gated potassium channels have been associated with epilepsy of variable severity. " 01/01/2023 - "KCNH5 encodes the voltage-gated potassium channel EAG2/Kv10.2. We aimed to delineate the neurodevelopmental and epilepsy phenotypic spectrum associated with de novo KCNH5 variants. " 10/01/2021 - "Mutations in the KCNQ2 gene, encoding the voltage-gated potassium channel, Kv7.2, cause neonatal epilepsies. " 01/01/2021 - "Voltage-gated potassium channels (VGPCs) play an important role in regulating neuronal excitability and abnormal VGPCs expression or function is related to epilepsy. "
2.	Limbic Encephalitis (Paraneoplastic Limbic Encephalitis) 05/01/2022 - "A primary diagnosis of voltage-gated potassium channel limbic encephalitis (VGKC-LE) was made. " 01/01/2021 - "Voltage-gated potassium channel antibody-associated limbic encephalitis was rare, and always associated with high antibody titres. " 12/09/2019 - "Review of a previous admission with hyponatraemia raised the possibility of voltage-gated potassium channel antibody-associated limbic encephalitis, although subsequent investigations deemed this unlikely as a cause of hyponatraemia. " 09/01/2019 - "We report a case of anti-voltage-gated potassium channel (VGKC) limbic encephalitis in a 47-year-old man presenting with a 2-year history of psychiatric features. " 09/01/2019 - "Anti-Voltage-gated Potassium Channel Limbic Encephalitis with Psychiatric Features: a Case Report."
3.	Glioma (Gliomas) 07/31/2003 - "Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas." 01/01/2014 - "High grade glioma mimicking voltage gated potassium channel complex associated antibody limbic encephalitis." 01/01/2018 - "Voltage-gated potassium channel blocker 4-aminopyridine induces glioma cell apoptosis by reducing expression of microRNA-10b-5p." 02/26/2015 - "Leucine-rich glioma inactivated 1 (LGI1) is a component of the voltage-gated potassium channel complex. " 01/01/2017 - "The aim of this study was to describe clinical and paraclinical characteristics of all Danish patients who tested positive for anti-voltage-gated potassium channels (VGKC)-complex, anti-leucine-rich glioma-inactivated 1 (LGI1) and anti-contactin-associated protein-2 antibodies in the serum/cerebrospinal fluid between 2009 and 2013 with follow-up interviews in 2015 and 2016. "
4.	Isaacs Syndrome (Neuromyotonia) 05/17/2019 - "Investigations were significant for raised CK levels, positive autoimmune panel, and anti-voltage-gated potassium channel (anti-VGKC) antibody that is involved in 35% reported cases of Isaacs' syndrome, with electrodiagnostic studies peculiar for Isaacs syndrome with negative imaging results. " 01/01/2018 - "Morvan syndrome, a rare voltage-gated potassium channel antibody disorder characterized by neuromyotonia with central nervous system dysfunction, was eventually diagnosed. " 01/01/2015 - "Isaacs' syndrome was diagnosed based on a positive voltage-gated potassium channel antibody titer of 1,007 pM. " 01/01/2011 - "The presence of anti-voltage-gated potassium channel antibody led to the diagnosis of Isaacs' syndrome. " 06/01/2004 - "Most commonly, neuromyotonia is an acquired immune-mediated disorder (Isaacs' syndrome) showing elevated antibody levels against presynaptic, voltage-gated, potassium channels. "
5.	Neoplasms (Cancer) 02/24/2023 - "A Meta-Analysis Study to Infer Voltage-Gated K+ Channels Prognostic Value in Different Cancer Types." 02/15/2023 - "Integrated analysis of the voltage-gated potassium channel-associated gene KCNH2 across cancers." 09/17/2022 - "Expression of the voltage-gated potassium channel KV10.1 (Eag1) has been detected in over 70% of human cancers, making the channel a promising new target for new anticancer drug discovery. " 01/01/2022 - "Eag1 (KV 10.1) is a voltage-gated potassium channel whose expression is very restricted in healthy tissues outside of the brain, while it is overexpressed in 70% of human tumors. " 08/20/2021 - "The KV10.1 voltage-gated potassium channel is highly expressed in 70% of tumors, and thus represents a promising target for anticancer drug discovery. "

Related Drugs and Biologics

1.	Antibodies
2.	Proteins (Proteins, Gene)
3.	Autoantibodies
4.	Leucine (L-Leucine)
5.	4-Aminopyridine (4 Aminopyridine)
6.	ezogabine (retigabine)
7.	Messenger RNA (mRNA)
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	GABA-B Receptor Agonists
10.	Carbonic Anhydrase IV

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Off-Label Use
4.	Optical Devices
5.	Contact Lenses