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Nonmuscle Myosin Type IIA

A nonmuscle isoform of myosin type II found predominantly in platelets, lymphocytes, neutrophils and brush border enterocytes.
Also Known As:
Myosin A; Myosin IIA; Non-muscle Myosin Type IIA; Myosin Type IIA, Non Muscle; Non muscle Myosin Type IIA; Myosin Type IIA, Non-Muscle
Networked: 68 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bresnick, Anne R: 5 articles (08/2011 - 05/2006)
2. Chandran, Bala: 4 articles (02/2014 - 01/2010)
3. Chakraborty, Sayan: 4 articles (02/2014 - 01/2010)
4. Pecci, Alessandro: 4 articles (08/2012 - 01/2003)
5. Savoia, Anna: 3 articles (08/2012 - 01/2003)
6. Balduini, Carlo L: 3 articles (10/2011 - 01/2003)
7. Dulyaninova, Natalya G: 3 articles (08/2011 - 08/2007)
8. Weber, David J: 3 articles (08/2011 - 05/2008)
9. Cota, Ernesto: 2 articles (01/2015 - 03/2010)
10. Tate, Edward W: 2 articles (01/2015 - 03/2010)

Related Diseases

1. Adenocarcinoma
2. Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
3. Infection
01/01/2010 - "This is the first study demonstrating the role of c-Cbl in viral entry as well as macropinocytosis, and provides the evidence that a signaling complex containing c-Cbl and myosin IIA plays a crucial role in blebbing and macropinocytosis during viral infection and suggests that targeting c-Cbl could lead to a block in KSHV infection."
02/01/2014 - "Mass spectrometry revealed the simultaneous association of CIB1 and EphA2 with the actin cytoskeleton modulating myosin IIA and alpha-actinin 4 molecules, and CIB1 knockdown reduced EphA2's association with myosin IIA and alpha-actinin 4. Collectively, these studies revealed for the first time that CIB1 plays a role in virus entry and macropinocytosis, and suggested that KSHV utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 mediated signaling involved in its entry, and CIB1 is an attractive therapeutic target to block KSHV infection. "
07/01/2010 - "parvum infection of cultured cholangiocytes results in the localized selective aggregation of myosin IIB but not myosin IIA at the region of parasite attachment, as assessed by dual-label immunofluorescence confocal microscopy. "
01/01/2015 - "Myosin A, actin, aldolase, and thrombospondin-related anonymous protein (TRAP) constitute the molecular core of the glideosome in the sporozoite, the mosquito stage that brings the infection into mammals. "
01/01/2010 - "Studies with the myosin II inhibitor blebbistatin demonstrated that myosin IIA is a biologically significant component of the c-Cbl signaling pathway and c-Cbl plays a new role in the recruitment of myosin IIA to the blebs during KSHV infection. "
4. Neoplasms (Cancer)
5. Muscular Diseases (Myopathy)

Related Drugs and Biologics

1. Vimentin
2. Proteins (Proteins, Gene)
3. Myosins (Myosin)
4. Myosin Type II
5. blebbistatin
6. Small Interfering RNA (siRNA)
7. Integrins
8. Paraffin
9. Clathrin
10. Actinin

Related Therapies and Procedures

1. Adjuvant Chemotherapy
2. Transcutaneous Electric Nerve Stimulation (TENS)