|1.||Gundy, Sarolta: 1 article (09/2015)|
|2.||Kiss, Krisztina: 1 article (09/2015)|
|3.||Farkas, Gyöngyi: 1 article (09/2015)|
|4.||Székely, Gábor: 1 article (09/2015)|
|5.||Vass, Nagyezsda: 1 article (09/2015)|
|6.||van Benthem, Jan: 1 article (01/2013)|
|7.||Johnson, George E: 1 article (01/2013)|
|8.||Hernández, Lya G: 1 article (01/2013)|
|9.||O'Donovan, Michael R: 1 article (11/2011)|
|10.||Priestley, Catherine C: 1 article (11/2011)|
|1.||Genetic Translocation (Chromosomal Translocation)
05/01/1994 - "The availability of chromosome-specific probes for mouse may prove very useful when analysing the behaviour of stable aberrations, as well as the testing of many suspected mutagenic carcinogens and aneugens in vivo for induction of chromosomal translocations and non-disjunction, respectively."
03/01/1987 - "Although aneuploidy is a serious human health problem, the experimental methodology devised until now to study the mechanisms involved in the induction of aneuploidy and for the screening of aneuploidy-inducing agents has not been so much employed to have the necessary validation. "
08/01/2005 - "Currently, there is no screening method sufficiently validated that can be used routinely to identify aneugenic agents in vitro because most conventional test systems rely on the labor-intensive microscopic assessment of the aneuploid cell population. "
01/01/2005 - "Genetic models involving mice with structural chromosomal rearrangements and transgenic animals have the potential to model conditions predisposing to aneuploidy in one or both sexes, and in this way to identify potential targets for aneugens and gender-effects. "
06/01/2001 - "Rapid detection may be of great interest in reproductive toxicology, as certain chemicals act as aneugens during meiosis, increasing the production of aneuploid germ cells. "
02/01/1998 - "Detecting chemical aneugens: a commentary to 'Aneuploidy: a report of an ECETOC task force'."
|3.||Chromosome Aberrations (Chromosome Abnormalities)
09/01/2015 - "In order to evaluate the adverse effects of various aneugens, the knowledge of the spontaneous frequency of numerical chromosome abnormalities in healthy population is fundamental. "
05/01/2008 - "Improving dose selection and identification of aneugens in the in vitro chromosome aberration test by integration of flow cytometry-based methods."
08/01/2005 - "Detection of numerical chromosomal aberrations by flow cytometry: a novel process for identifying aneugenic agents."
09/24/2002 - "Some of these chemicals have the potential to act as aneugens, substances that cause numerical chromosomal aberrations (NCAs). "
02/01/1998 - "Compared with the chromosomal aberration test, it detects aneugens more reliably, it is faster and easier to perform, and it has more statistical power and the possibility of automation."
05/01/2003 - "These techniques can now be used to investigate relationships between the induction of chromosomal loss, non-disjunction and polyploidy by aneuploidy-inducing agents. "
02/01/1998 - "3. The majority of definitive aneugens evaluated induce polyploidy in vitro. "
11/01/1997 - "By using the aneugenic model compound colchicine and X chromosome centromere-specific FISH, we have shown that besides chromosome loss in binucleated cells, other effects such as MN in mononucleated cells, cells arrested at metaphase, polyploidy and non-disjunction are also consistently induced by aneugenic agents. "
08/01/2005 - "Treatments with two known aneugenic agents, griseofulvin, and paclitaxel (taxol), resulted in a dose-related increase in the mitotic index, aneuploidy, and polyploidy. "
09/05/1997 - "Various aneugens were reported to induce structural chromosomal aberrations beside their influence on cell division and their aneugenic potential To asses, whether a relationship between disturbance of cell division and clastogenic potential exists, CHO cells were treated with the well-known aneugens colcemid, colchicine and vincristine and investigated for the induction of structural chromosomal aberrations, polyploid cells and alterations in mitotic index. "
04/01/1993 - "As regards exposure to aneugenic agents, considerations on cancer risk evaluation are presented."
01/01/2013 - "Distinguishing between clastogens and aneugens is vital in cancer risk assessment because the default assumption is that clastogens and aneugens have linear and non-linear dose-response curves, respectively. "
08/01/2011 - "The MN assay allows detection of both aneugens and clastogens, shows simplicity of scoring, is widely applicable in different cell types, is internationally validated, has potential for automation and is predictive for cancer. "
|5.||Griseofulvin (Grifulvin V)
|6.||Etoposide (VP 16)