Carbonic Anhydrase II

A cytosolic carbonic anhydrase isoenzyme found widely distributed in cells of almost all tissues. Deficiencies of carbonic anhydrase II produce a syndrome characterized by OSTEOPETROSIS, renal tubular acidosis (ACIDOSIS, RENAL TUBULAR) and cerebral calcification. EC 4.2.1.-

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Networked: 240 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Supuran, Claudiu T: 6 articles (03/2021 - 06/2009)
2.	McKenna, Robert: 6 articles (01/2020 - 02/2005)
3.	Parkkila, Seppo: 5 articles (03/2017 - 07/2002)
4.	Silverman, David N: 4 articles (02/2011 - 02/2005)
5.	Parkkila, Anna-Kaisa: 4 articles (05/2010 - 07/2002)
6.	Al-Harrasi, Ahmed: 3 articles (01/2022 - 01/2020)
7.	Halim, Sobia Ahsan: 3 articles (01/2022 - 01/2020)
8.	Khan, Ajmal: 3 articles (01/2022 - 01/2020)
9.	Khan, Majid: 3 articles (01/2022 - 01/2020)
10.	Adamus, Grazyna: 3 articles (01/2016 - 03/2009)

Related Diseases

1.	Carcinoma (Carcinomatosis) 01/16/2014 - "Immunoblot analyses using the patient's serum detected autoantibodies against recoverin, CRMP-5, and α-enolase, but not carbonic anhydrase II. Neuroretinitis once resolved after almost remission of carcinoma on imaging but it recurred following the recurrence of carcinoma. " 01/01/1989 - "This type of tumor is distinguished from the other carcinomas of the kidney with light cytoplasm (formerly called "hypernephroid") by (a) a positive Hale's iron colloid stain of the cytoplasm, (b) the occurrence of numerous invaginated vesicles within the cytoplasm that resemble the invaginated vesicles of intercalated cells of the collecting duct system, and (c) a positive immunoreaction of both the plasma membrane and the cytoplasm with antibodies to the epithelial membrane antigen (EMA) and carbonic anhydrase C (CAC), respectively. " 02/01/1995 - "Of a series of 17 choroid plexus carcinomas (five of which were classed as moderately differentiated and 12 as anaplastic) 17 expressed antigens to transthyretin, transferrin and cathepsin and 16 expressed carbonic anhydrase II. Eleven expressed at least one epithelial marker (cytokeratin or epithelial membrane antigen). "
2.	Retinitis 01/16/2014 - "Immunoblot analyses using the patient's serum detected autoantibodies against recoverin, CRMP-5, and α-enolase, but not carbonic anhydrase II. Neuroretinitis once resolved after almost remission of carcinoma on imaging but it recurred following the recurrence of carcinoma. "
3.	Neoplasms (Cancer) 06/01/2019 - "The expression levels of carbonic anhydrase II (CA2) in the tumor and adjacent tissues were determined using reverse transcription-quantitative polymerase chain reaction analysis and immunohistochemistry. " 08/01/2012 - "[Clinicopathological significance of the expression of carbonic anhydrase II in human pancreatic invasive ductal cancer]." 09/01/2009 - "Carbonic anhydrase II positivity in the endothelium was associated with cell proliferation and malignancy grade. " 10/01/2005 - "Tumor cells expressed GFAP and S-100 and to lesser extent carbonic anhydrase II. The immunoreaction for EMA showed diffuse granular positivity, decorated a few extracellular lumina, and highlighted intracytoplasmic lumina in a few cells. " 08/10/2005 - "Human carbonic anhydrase II was detected in normal colorectal mucosa but not in primary cancer lesion and hepatic metastasisnegion. "
4.	Osteopetrosis 09/08/2023 - "Since carbonic anhydrase II (CA-II) deficiency is a major cause of osteopetrosis, CA-II activators might be an attractive potential treatment option for osteopetrosis patients. " 02/06/2023 - "To address this research gap, the authros perfomed a comprehensive review on osteopetrosis and its types, pathogenesis of dental abnormalities, and the role of carbonic anhydrase II activators in osteopetrosis treatment. " 02/06/2023 - "There is a lack of a comprehensive review on osteopetrosis, pathogenesis of dental abnormalities, and the role of carbonic anhydrase II activators in osteopetrosis treatment. " 02/06/2023 - "Since deficiency of carbonic anhydrase II is a major cause behind osteopetrosis, carbonic anhydrase II activators have a large number of applications in osteopetrosis treatment. " 02/06/2023 - "Carbonic Anhydrase II Activators in Osteopetrosis Treatment: A Review."
5.	Renal Tubular Acidosis (Distal Renal Tubular Acidosis) 01/13/2023 - "It has been demonstrated that anti-carbonic anhydrase II (anti-CA II) antibody is correlated with renal tubular acidosis in pSS; however, no further details about urinary acidification defect have been reported, and the antibody's relationship with other organ impairments remains unknown. " 04/01/1998 - "Correction of renal tubular acidosis in carbonic anhydrase II-deficient mice with gene therapy." 01/01/2008 - "Carbonic anhydrase II (CAII)-deficient mice were created to study the syndrome of CAII deficiency in humans including osteopetrosis, renal tubular acidosis, and cerebral calcification. " 01/01/2018 - "The deficiency of carbonic anhydrase II causes a moderate form, presenting classically as a triad of osteopetrosis, renal tubular acidosis (RTA), and cerebral calcification. " 06/01/2009 - "Carbonic anhydrase II (CA II) deficiency is an extremely rare autosomal recessive disorder, characterised by a triad of osteopetrosis, renal tubular acidosis and cerebral calcifications. "

Related Drugs and Biologics

1.	Autoantibodies
2.	Phosphopyruvate Hydratase (Enolase)
3.	Recoverin
4.	Antibodies
5.	Enzymes
6.	Proteins (Proteins, Gene)
7.	Adenosine Triphosphatases (ATPase)
8.	Cathepsin K
9.	Carbonic Anhydrase I
10.	Retinaldehyde (Retinal)

Related Therapies and Procedures

1.	Therapeutics
2.	Light Coagulation
3.	Lasers (Laser)
4.	Injections
5.	Drug Therapy (Chemotherapy)