Collagen Type VI

A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.

Also Known As:

Collagen Type VI, alpha1 Chain; Collagen Type VI, alpha1 Subunit; Collagen Type VI, alpha2 Subunit; Collagen Type VI, alpha3 Chain; Collagen Type VI, alpha3 Subunit; Collagen Type-VI, alpha2 Chain; Collagen alpha1(VI); Collagen alpha2(VI); Collagen alpha3(VI); Intima Collagen; Procollagen Type VI; Type VI (Intima) Collagen; Type VI Collagen; Type VI Procollagen; Collagen Type VI, alpha2 Chain; Collagen, Intima; Collagen, Type VI; Procollagen, Type VI

Networked: 222 relevant articles (0 outcomes, 30 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Scleroproteins: 74
    - Extracellular Matrix Proteins: 3148
      - Collagen: 52417
        Non-Fibrillar Collagens: 13
        Collagen Type VI: 222
        endotrophin: 47
        human Col6a1 protein
        human COL6A2 protein
        human COL6A3 protein
        human COL6A4P1 protein
        human COL6A5 protein
        human COL6A6 protein
        mouse Col6a1 protein
        mouse COL6A2 protein
        zebrafish Col6a1 protein
        zebrafish col6a4a protein

Experts

1.	Genovese, Federica: 9 articles (01/2022 - 01/2017)
2.	Karsdal, Morten A: 9 articles (01/2022 - 01/2017)
3.	Karsdal, Morten Asser: 8 articles (01/2022 - 01/2011)
4.	Rasmussen, Daniel Guldager Kring: 4 articles (01/2022 - 12/2017)
5.	Leeming, Diana Julie: 4 articles (12/2020 - 01/2011)
6.	Bonaldo, Paolo: 4 articles (01/2019 - 03/2009)
7.	Bönnemann, Carsten G: 4 articles (01/2011 - 06/2002)
8.	Neufert, Clemens: 3 articles (03/2022 - 01/2019)
9.	Neurath, Markus F: 3 articles (03/2022 - 01/2019)
10.	Bakker, Stephan J L: 3 articles (01/2022 - 01/2017)

Related Diseases

1.	Down Syndrome (Down's Syndrome) 10/01/2007 - "This study demonstrates a homogeneous overexpression of the genes encoding for alpha1 and alpha2 chains of Collagen type VI, and SOD in nuchal skin of human trisomy 21 fetuses. " 05/15/2002 - "Type VI collagen (Col VI) is expressed in the developing AV canal extracellular matrix, and has been associated with trisomy 21 AV canal defects in human genetic studies. " 09/01/1996 - "These data support molecular genetic studies which have indicated that type VI collagen is involved in the heart defect phenotype seen in trisomy 21." 10/01/2007 - "Quantitative evaluation of collagen type VI and SOD gene expression in the nuchal skin of human fetuses with trisomy 21." 12/01/2003 - "Collagen type VI expression during cardiac development and in human fetuses with trisomy 21."
2.	Neoplasms (Cancer) 01/01/2021 - "Background: Collagen type VI alpha 1 (COL6A1) has been found to be dysregulated in several human malignancies. " 09/01/1999 - "Type VI collagen immunoreactivity in skeinoid fibers in small intestinal stromal tumors." 01/27/1995 - "We suggest that type VI collagen may be involved in tumor cells infiltration and invasion of healthy rat brain tissues. " 12/01/1993 - "Type VI collagen inclusions are usually found in lymphohistiocytic neoplasms. " 06/01/2023 - "This study aimed to investigate the expression of type VI collagen α3 chain (COL6a3) in neoplastic cells of canine mammary gland carcinomas (CMGCs) using immunohistochemistry (IHC) and to evaluate the association between COL6a3 expression and tumor histological features, histological grades, and the differentiation status of neoplastic epithelial cells. "
3.	Melanoma (Melanoma, Malignant) 07/01/1996 - "This study was designed to investigate the possible expression of type VI collagen in the stroma of choroidal and ciliary body melanomas. " 07/01/1996 - "Type VI collagen was detected in tissue sections from five primary choroidal melanomas and three melanomas involving the choroid and ciliary body in the subendothelial compartment of the microcirculation and in avascular areas by immunohistochemistry. " 06/01/2006 - "Collagen type VI was expressed in nevi (5/5) and primary melanomas below a Breslow thickness of 1 mm (3/3), but was lost in 24/24 primary melanomas above this threshold, and in metastatic melanomas (10/10). " 07/01/1996 - "The presence of type VI collagen in the melanoma tumor stroma reflects active remodeling of the uveal extracellular matrix microenvironment by the melanoma cells themselves. " 09/01/2003 - "Type VI collagen and hyaluronan serum levels were also significantly increased in stage I/II melanoma. "
4.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2011 - "The aim of this study was to develop an ELISA detecting a fragment of type VI collagen generated by MMP-2 and MMP-9, and evaluate this assay in two preclinical models of liver fibrosis. " 01/01/1999 - "[Dynamic changes in the expression of type VI collagen in mice with schistosomal liver fibrosis]." 03/01/1997 - "Serum 7S collagen and type VI collagen are useful markers for diagnosing liver fibrosis. " 04/01/1995 - "Type VI collagen gene expression in experimental liver fibrosis: quantitation and spatial distribution of mRNAs, and immunodetection of the protein." 01/14/2005 - "The aim of this study was to identify better noninvasive predictors of hepatic fibrosis, with special focus on markers of liver fibrosis, type VI collagen 7S domain and hyaluronic acid. "
5.	Fibrosis (Cirrhosis) 01/01/2023 - "Accumulating evidence suggests that collagen type VI is tightly linked to fibrosis and may be a marker of systemic fibrosis and ageing. " 11/28/2022 - "Enhanced de-novo collagen type VI (COL VI) formation has been associated with kidney and cardiovascular fibrosis. " 06/01/2019 - "Type VI collagen also plays a role in cardiac fibrosis. " 01/01/2019 - "Type VI collagen (ColVI), a Fra-2 transcriptional target, is up-regulated in three lung fibrosis models, and macrophages promote myofibroblast activation in vitro in a ColVI- and Fra-2-dependent manner. " 01/01/2018 - "Enhanced de novo collagen type VI (COL VI) formation has been associated with renal fibrosis and CKD. "

Related Drugs and Biologics

1.	Collagen
2.	Tenascin
3.	Elastin
4.	Hyaluronic Acid (Hyaluronan)
5.	Collagen Type III (Type III Collagen)
6.	Proteins (Proteins, Gene)
7.	Transforming Growth Factor beta (TGF-beta)
8.	Antigens
9.	laminin 1
10.	Myosin Heavy Chains (Myosin Heavy Chain)

Related Therapies and Procedures

1.	Therapeutics
2.	Bariatric Surgery
3.	Kidney Transplantation
4.	Artificial Respiration (Mechanical Ventilation)
5.	Plasmapheresis