Limb Salvage

An alternative to AMPUTATION, SURGICAL in patients with neoplasms, ischemia, fractures, and other limb-threatening conditions. Generally, sophisticated surgical procedures such as vascular surgery and reconstruction are used to salvage diseased limbs.

Also Known As:

Networked: 3365 relevant articles (226 outcomes, 291 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Attinger, Christopher E: 25 articles (09/2022 - 04/2002)
2.	Evans, Karen K: 18 articles (09/2022 - 01/2015)
3.	Dosluoglu, Hasan H: 16 articles (10/2022 - 11/2006)
4.	Harris, Linda M: 16 articles (10/2022 - 11/2006)
5.	Guo, Wei: 16 articles (12/2020 - 10/2006)
6.	Dryjski, Maciej L: 15 articles (10/2022 - 11/2006)
7.	Li, Jing: 15 articles (02/2022 - 06/2010)
8.	Mavrogenis, Andreas F: 15 articles (12/2021 - 12/2003)
9.	Wang, Zhen: 14 articles (02/2022 - 06/2010)
10.	Guo, Zheng: 13 articles (01/2022 - 06/2010)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2023 - "Because recent advances in systemic therapy have improved the prognosis of patients who undergo limb salvage surgery for musculoskeletal tumors, data on the long-term durability of endoprosthetic reconstructions have become increasingly important. " 11/01/2006 - "For large, deep tumors or tumors that are close to important neurovascular structures or bone, the addition of radiotherapy to resection has improved local control and increased limb salvage without affecting overall survival. " 06/25/2018 - "Conclusion: Early and mid-term bypass patency rates, the high percentage of limb salvage, and the oncologic outcome underline the efficacy of en bloc resection of soft-tissue tumors involving major vessels of the lower limbs. " 01/01/2016 - "Limb salvage using an elbow prosthesis is effective in obtaining good functional results and reliable local tumor control. " 12/01/1999 - "Both prosthetic replacement and allograft advantages, the use of large bone allografts with metallic prosthesis for the treatment of bone tumors near or involving joints can be applied with good results in selected patients having limb salvage surgery."
2.	Ischemia 12/01/2003 - "The best TcpO(2) parameters to predict the efficacy of spinal cord stimulation to improve limb salvage in patients with inoperable critical leg ischemia." 01/01/1996 - "The limb salvage rate for patients with limb-threatening ischemia was 98% at a mean follow-up of 14 months +/- 7. Technical success and complication rates for percutaneous iliac artery revascularization with use of Wallstents are favorable, symptoms improved in the majority of patients, and excellent secondary patency can be achieved. " 10/16/2020 - "Injecting the CM collected from ps-TNC treated hADSCs into the mouse hindlimb ischemia model (ps-TNC-CM group) showed significantly improved angiogenesis in the lesions, with improved limb salvage and decreased muscle degeneration compared to the group injected with CM collected from normal hADSCs (CM group). " 04/01/2014 - "Compared with injection of either monolayer culture CM or human ADSC, injection of spheroid culture CM to an ischemic region in mice significantly enhanced endothelial cell growth, CD34(+)/PTPRC(-) (endothelial progenitor) cell mobilization from bone marrow, and bone marrow cell homing to the ischemic region, resulting in improved blood vessel density, limb salvage, and blood perfusion in a mouse hindlimb ischemia model. " 09/01/2005 - "At 12 months, the secondary patency and limb salvage rates were, respectively, 87.5+/-8.9 and 100% in group I and 87.5+/-8.93 and 94.45+/-6.71% in group II. Treatment of SFA occlusive lesions (excluding TASC D lesions) with the Hemobahn covered stent yielded good results for both claudicants with good outflow and patients with critical or acute ischemia with bad outflow, if concomitant outflow-improving procedures were performed."
3.	Wounds and Injuries (Trauma) 10/01/2018 - "Distal revascularization combined with omental free-flap or flow-through flap is highly effective for limb salvage in CLTI patients with complex wounds. " 10/01/2017 - "In conclusion, arterial injuries resulted in significant complications for patients with lower extremity fractures requiring flap coverage, although limb salvage was still effective in most cases." 03/01/2011 - "Recent advances in the microsurgical techniques involved in free vascularized bone transfers for complex limb injuries have dramatically improved limb salvage and musculoskeletal reconstruction. " 01/01/2018 - "Such information would also enable optimal wound management, leading to successful wound healing and improved limb salvage and survival rates." 11/01/2004 - "Although early mortality is high, deaths are not related to the flap procedure itself, local outcome is excellent, and graft and limb salvage are good; results are much worse if an initially draining wound is treated too late. "
4.	Osteosarcoma (Osteogenic Sarcoma) 01/01/1986 - "Chemotherapy has very much improved the prognosis of osteosarcoma, trials on limb salvage surgery are indicated therefore. " 02/01/1995 - "Improved concepts of en bloc resection and better reconstructive techniques suggest that limb-salvage procedures are not only possible but can provide excellent functional result in patients with osteosarcoma. " 11/01/2022 - "Limb salvage surgery has a higher complication rate than amputation but is still beneficial for patients younger than 10 years old with osteosarcoma of an extremity." 03/01/2021 - "However, Kaplan Meier survival analysis showed a significant improvement in the disease-free survival patients who underwent limb salvage surgery (LSS) than amputated patients (p-value 0.002), whereas poorer survival was observed among conventional osteosarcomas compared to non-conventional osteosarcoma (p-value 0.01). " 03/01/2018 - "Neoadjuvant chemotherapy has significantly improved the 5-year survival and limb salvage rates in osteosarcoma since the 1870s. "
5.	Pain (Aches) 02/01/2005 - "Twenty-three patients (85.2%), were clinically re-occluded within 1 year, but complete and partial wound healing was achieved in 80% (16/20) and rest pain improvement in 57% (4/7), so that overall limb salvage was 74% (20/27). " 01/01/2005 - "Twenty-three patients (85.2%), were clinically re-occluded within 1 year, but complete and partial wound healing was achieved in 80% (16/20) and rest pain improvement in 57% (4/7), so that overall limb salvage was 74% (20/27). " 05/01/1995 - "SCS provided long-term pain relief but limb salvage at 18 months was not significantly improved by SCS in this rather small study. " 12/01/2022 - "Although just a single participant, within-subject comparisons provide quantitative evidence that, for some individuals, delayed/late (transtibial) amputation after prolonged limb salvage may be beneficial in reducing pain and restoring function." 10/01/2016 - "Urgent endovascular treatment in selected patients with acute on chronic CLI represents a safe and effective option with good results in terms of healing of the ischemic lesions, relief of rest pain, and limb salvage. "

Related Drugs and Biologics

1.	Polytetrafluoroethylene (Teflon)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Melatonin
4.	Anti-Bacterial Agents (Antibiotics)
5.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
6.	Heparin (Liquaemin)
7.	Oxygen (Dioxygen)
8.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
9.	Superoxide Dismutase
10.	Ointments (Pastes)

Related Therapies and Procedures

1.	Surgical Amputation (Amputations)
2.	Drug Therapy (Chemotherapy)
3.	Neoadjuvant Therapy
4.	Therapeutics
5.	Radiotherapy