CD40 Ligand (CD40L)

A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.

Also Known As:

CD40L; Antigen, CD154; CD154 Antigen; T-B Cell Activating Molecule; TNF Superfamily, Member 5; gp39 Antigen, T-Cell; T-Cell gp39 Antigen; gp39 Antigen, T Cell; Antigens, CD154; CD154 Antigens; Tumor Necrosis Factor Ligand Superfamily Member 5

Networked: 2247 relevant articles (90 outcomes, 283 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lutgens, Esther: 27 articles (05/2022 - 01/2002)
2.	Davì, Giovanni: 15 articles (01/2016 - 07/2002)
3.	Aukrust, Pål: 15 articles (02/2015 - 01/2003)
4.	Libby, Peter: 15 articles (11/2011 - 12/2002)
5.	Gerdes, Norbert: 14 articles (05/2022 - 12/2002)
6.	Ochs, Hans D: 13 articles (01/2019 - 04/2002)
7.	Beckers, Linda: 11 articles (05/2022 - 05/2007)
8.	Cognasse, Fabrice: 11 articles (01/2022 - 07/2006)
9.	Garraud, Olivier: 11 articles (01/2022 - 07/2006)
10.	Zirlik, Andreas: 11 articles (12/2019 - 06/2005)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2008 - "CD40/CD40L signaling promotes both B cell and CTL responses in vivo, the latter being beneficial in tumor models. " 11/01/1997 - "Mice injected with cells that expressed CD40L had a significant reduction in average tumor size as compared to controls (p < 0.0001). " 02/01/1997 - "The understanding of the biology of CD40L has improved our diagnostic and therapeutic repertoire in the management of several human diseases, including CD40+ tumors." 04/17/2014 - "Targeted delivery of CD40L to cancer cells is a promising strategy that may help to trigger cancer-localized activation of CD40 and can be modified to exert additional anti-cancer activity via the targeting domain." 11/01/2021 - "The potential of intratumoral CD40L gene transfer as treatment of cancer was illustrated by the clinical improvement in two out of seven patients."
2.	Infections 03/15/2013 - "Most C57 mice eliminated the strain within 3 days whereas infection remained in C57-cd40l(-/-) mice until day 14. " 09/01/2014 - "Our results demonstrated that the CD40L adjuvant enhanced the functional quality of anti-Env antibody response and breadth of anti-SIV CD8 and CD4 T cell responses, significantly delayed the acquisition of heterologous mucosal SIV infection, and improved viral control. " 04/20/1998 - "To study the role of CD40L in mediating protection against infection with H. " 05/15/2014 - "In this study we show that soluble CD40 ligand also promotes the formation of complexes between inflammatory monocytes and activated platelets (PMCs), which are detected by flow cytometry as monocytes that express excess of CD61, a platelet marker, and that these complexes are increased in individuals with HIV-1 infection. " 10/01/2005 - "cruzi with the murine CD40L gene and to study the consequences of this transfection on the course of infection. "
3.	Inflammation (Inflammations) 01/01/2022 - "As a general rule, all of the studies presented in this review show that platelets are capable of covering most of the stages of inflammation, primarily through the CD40L/CD40 interaction, thus confirming their own role in this pathophysiological condition." 10/01/2017 - "The aim of this study was to locally measure soluble CD40 ligand (sCD40L), in conjunction with inflammation and coagulation activation markers, during CEA. " 07/01/2006 - "Recent studies have demonstrated that PLTs promote immunity and inflammation mainly by means of the CD40/CD40L pathway. " 01/01/2006 - "The aim of the study was estimation of a concentration soluble form of CD40, CD40L (CD154) in the bacterial and viral inflammation of the central nervous system in two compartments - blood circulation and intrathecally, before and after the treatment. " 01/01/2003 - "These data provide novel insight into the mechanism through which elevated levels of soluble CD40 ligand may reflect cardiovascular risk in humans and illustrate the potential value of interfacing high-resolution MRI with studies of vascular inflammation."
4.	Thrombosis (Thrombus) 09/01/2018 - "However, the exact mechanisms linking the CD40/CD40L system and the soluble form of CD40L (sCD40L) with microvascular thrombosis are currently a topic of intensive research. " 12/07/2017 - "CD40L has been shown to potentiate platelet activation and thrombus formation, involving both CD40-dependent and -independent mechanisms. " 01/01/2017 - "CD40L and Its Receptors in Atherothrombosis-An Update." 06/01/2015 - "This role of CD40L exceeds the no more than modest role of CD40 in thrombus formation." 06/01/2015 - "To investigate the roles and signaling pathways of CD40L and CD40 in platelet-platelet interactions and thrombus formation under conditions relevant for atherothrombosis. "
5.	Melanoma (Melanoma, Malignant) 01/01/2022 - "In this work, we have tested the efficacy of conditionally-replicating adenoviruses (CRAds) with and without selected immunostimulatory payloads, murine CD40L (mCD40L) or 4-1BBL (m4-1BBL), in an immune competent mouse model of melanoma. " 01/01/2017 - "Herein, we demonstrate immune profiling data from melanoma patients treated with an adenovirus-based CD40 ligand gene therapy (AdCD40L). " 01/01/2016 - "We showed that, like SP CD4+ T cells, and through CD40L involvement, DP T cells are able to induce both proliferation and differentiation of B lymphocytes and maturation of functional DCs able to efficiently prime cytotoxic melanoma-specific CD8 T-cell responses. " 01/01/2016 - "Based on a comparative transcriptome analysis between intra-melanoma SP CD4+, SP CD8+ and DP autologous melanoma-infiltrating T-cell compartments, we evidenced an overexpression of the CD40L co-stimulatory molecule on activated DP T cells. " 01/01/2016 - "CD40L confers helper functions to human intra-melanoma class-I-restricted CD4+CD8+ double positive T cells."

Related Drugs and Biologics

1.	CD40 Ligand (CD40L)
2.	Vaccines
3.	Proteins (Proteins, Gene)
4.	Interleukin-12 (IL 12)
5.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
6.	Ligands
7.	C-Reactive Protein
8.	P-Selectin
9.	Cytokines
10.	Antigens

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Bariatric Surgery
4.	Precision Medicine
5.	Drug Therapy (Chemotherapy)