|1.||Lu, Wuyuan: 12 articles (12/2015 - 03/2003)|
|2.||Bevins, Charles L: 6 articles (01/2009 - 08/2005)|
|3.||Mukae, Hiroshi: 5 articles (09/2010 - 02/2002)|
|4.||Wehkamp, Jan: 5 articles (02/2010 - 12/2005)|
|5.||Lehrer, Robert I: 5 articles (09/2009 - 01/2003)|
|6.||Bdeir, Khalil: 4 articles (05/2010 - 08/2004)|
|7.||Wang, Wei: 4 articles (11/2009 - 10/2006)|
|8.||Fellermann, Klaus: 4 articles (01/2009 - 12/2005)|
|9.||Ishimoto, Hiroshi: 3 articles (09/2010 - 10/2004)|
|10.||Kohno, Shigeru: 3 articles (09/2010 - 10/2004)|
|1.||Crohn Disease (Crohn's Disease)
12/01/2011 - "Extensive copy number variation is observed for the DEFA1A3 gene encoding alpha-defensins 1-3. The objective of this study was to determine the involvement of alpha-defensins in colonic tissue from Crohn's disease (CD) patients and the possible genetic association of DEFA1A3 with CD. "
07/01/2008 - "The aim of this study was to independently assess whether NOD2, alpha-defensins and Crohn's disease are linked. "
02/01/2010 - "Adult ileal Crohn's disease (CD) is characterized by a specific decrease in ileal Paneth cell alpha-defensins. "
01/01/2009 - "Reduced expression of Paneth cell antimicrobial alpha-defensins, human defensin (HD)-5 and -6, characterizes Crohn's disease (CD) of the ileum. "
11/01/2008 - "Conspicuously, there is a relative lack of Paneth-cell alpha-defensins in ileal Crohn's disease (CD), both in the absence of a pattern recognition receptor nucleotide-binding oligomerization domain 2 (NOD2) frameshift mutation and, even more pronounced, in its presence. "
10/01/2011 - "Additionally, substantially increased expression of alpha-defensins in the inflamed colonic mucosa of children with IBD raises the question for their potential involvement in modulating inflammation in these patients."
08/01/2010 - "The chronic inflammation was not due to increased epithelial apoptosis or permeability, but to a decreased Paneth cell-derived alpha-defensins (cryptdins) and RegIII-gamma and increased commensal bacteria translocation. "
02/01/2007 - "Despite these associations there was no significant relationship between breast milk alpha-defensins and mother-to-child transmission, suggesting a complex interplay between breast milk HIV-1, inflammation, and antiinfective factors."
05/01/2004 - "This might be a hint towards a possible role of alpha-defensins in the down-regulation of inflammation."
06/01/2002 - "Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensins."
|3.||Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
07/15/2007 - "In this study, we examine the interactions between alpha-defensins and IL-1beta and the role of defensin deficiency in the pathogenesis of inflammatory bowel disease. "
12/01/2008 - "Alpha-defensins and clostridium difficile recent growing concerns in inflammatory bowel disease."
09/15/2007 - "Although alpha-defensins have been implicated in the pathogenesis of inflammatory bowel disease, their immunomodulatory functions are poorly understood. "
08/01/2005 - "New data suggest that deficient expression of Paneth cell alpha-defensins may contribute to the pathophysiology of Crohn's disease, a chronic inflammatory bowel disease."
06/01/2002 - "Human alpha-defensins contribute to local intestinal host defense as part of innate immunity and may be of major relevance in microbial infection and chronic inflammatory bowel disease. "
05/01/2014 - "In recent years, the scientific publications about disorder the scientific publications appeared concerning derangement of content of alpha-defensins in neutrophils of patients with atherosclerosis. "
10/01/2007 - "We asked, therefore, if alpha-defensins are risk factors for the presence and severity of atherosclerosis. "
08/15/2000 - "The alpha-defensins released from activated neutrophils may provide a link between inflammation and atherosclerosis by changing the pattern of LDL catabolism from LDL-R to the less efficient LDL-R-independent, proteoglycan-dependent pathway. "
09/15/1999 - "Prompted by putative links between inflammation and atherosclerosis, we previously reported that alpha-defensins released by neutrophils are present in human atherosclerotic lesions and promote the binding of lipoprotein(a) [Lp(a)] to vascular cells without a concomitant increase in degradation. "
05/01/2014 - "[The alpha-defensins, peptides and proteins synthesized and liberated by neutrophils under atherosclerosis of different localization]."
|5.||Bacterial Infections (Bacterial Infection)
01/01/2008 - "The importance of Paneth cells alpha-defensins emerged from studies of enteric bacterial infection in genetically modified mice, as well as from recent studies linking reduced levels of these alpha-defensins to Crohn's disease localized to the ileum. "
01/01/2006 - "Present understanding of the role of staphylokinase during bacterial infection is based on its interaction with the host proteins, alpha-defensins and plasminogen. "
06/01/2007 - "Many eukaryotes use antimicrobial peptides (alpha-defensins, beta-defensins, gamma-defensins, and cathelicidins) in innate immune responses to fight bacterial infections. "
|3.||Proteins (Proteins, Gene)
|6.||Leukocyte Elastase (Neutrophil Elastase)
|7.||von Willebrand Factor
|8.||Factor VII (Proconvertin)
|10.||Messenger RNA (mRNA)