|1.||Rajarathnam, Krishna: 2 articles (01/2015 - 07/2004)|
|2.||Richardson, Ricardo M: 2 articles (03/2014 - 05/2003)|
|3.||Verbeke, Hannelien: 2 articles (01/2012 - 10/2011)|
|4.||Van Damme, Jo: 2 articles (01/2012 - 10/2011)|
|5.||Struyf, Sofie: 2 articles (01/2012 - 10/2011)|
|6.||Singh, Rakesh K: 2 articles (01/2010 - 02/2006)|
|7.||Singh, R K: 2 articles (05/2009 - 10/2001)|
|8.||Varney, M L: 2 articles (05/2009 - 10/2001)|
|9.||Seval, Yasemin: 2 articles (03/2006 - 03/2005)|
|10.||Ulukus, Murat: 2 articles (03/2006 - 03/2005)|
01/01/2014 - "The knockdown of CXCL8/Cxcl2 receptors (CXCR1/Cxcr1 and Cxcr2) reduced MTX-induced CRT exposure in both human and murine cancer cells, as well as the capacity of the latter-on exposure to MTX-to elicit an anticancer immune response in vivo. "
01/01/2010 - "Recent findings have suggested multiple functional implications of CXCL8 and its cognate receptors, CXCR1 and CXCR2, in melanoma pathogenesis, thus underscoring their importance as targets for cancer therapy. "
01/01/2012 - "Agents targeting IL8 or its receptor CXCR1 may be useful for the treatment of HER2/HER3/IL8-positive breast cancers with invasive traits."
08/01/2012 - "Interleukin-8 (IL-8) is a pro-inflammatory cytokine which exerts its effects via binding to 2 receptors, CXCR1 and CXCR2 and is known to promote angiogenesis, mitogenesis and motogenesis in cancer. "
11/15/2008 - "The levels of IL-8 and its receptor, CXCR1, were higher in tumors than in homologous normal mucosa. "
|2.||Neoplasm Metastasis (Metastasis)
08/01/2014 - "CXCL8 receptors, CXCR1 and CXCR2, were positively stained in PTC cell lines and tissues, though no association with lymph node metastasis or extrathyroid extension. "
06/01/2012 - "Recent studies showed that interleukin-8 (IL-8) and its receptors (CXCR1 and CXCR2) are significantly upregulated in both the tumor and its microenvironment, and act as key regulators of proliferation, angiogenesis, and metastasis. "
10/01/2001 - "In the present study, we examined the expression of a multifunctional cytokine, interleukin 8 (IL-8), and its receptors, CXCR1 and CXCR2, in human colon carcinoma cells with different metastatic potentials and determined their role in modulating phenotypes associated with metastasis. "
01/01/2010 - "Concomitantly, Wicha's laboratory developed a strategy to selectively target cancer stem cells, retarding tumour growth and reducing metastasis by blocking the IL-8 receptor CXCR1 using either an inhibitor, repertaxin or a specific blocking antibody."
|3.||Prostatic Neoplasms (Prostate Cancer)
06/01/2005 - "Expression of the interleukin-8 receptor CXCR1 was negative or low in benign prostatic tissue and was frequently increased in malignant cells of high-grade prostatic intraepithelial neoplasia and prostate cancer; however, CXCR1 was not detected in the neuroendocrine tumor cells, suggesting a paracrine mechanism by which interleukin-8 produced by neuroendocrine tumor cells stimulates androgen-independent proliferation of prostate cancer. "
06/01/2006 - "We examined the most representative single nucleotide polymorphisms (SNPs) for the IL-8 and its receptors (CXCR1 and CXCR2) genes, and conducted a case-control study nested within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study to examine if these SNPs are associated with susceptibility to and prognosis of prostate cancer. "
|4.||Breast Neoplasms (Breast Cancer)
02/01/2013 - "Breast cancer cell line studies indicate that IL-8 via its cognate receptors, CXCR1 and CXCR2, is important in regulating breast CSC activity. "
02/01/2010 - "We report here the development of a strategy to target these breast cancer stem cells (CSCs) through blockade of the IL-8 receptor CXCR1. "
|5.||Chronic Hepatitis B
04/01/2012 - "[Influence of IFN on expression of chemokine receptor CXCR1, CXCR2 and their ligand IL-8 in the patients with chronic hepatitis B]."
04/01/2012 - "To study the mRNA levels of chemokine receptor CXCR1, CXCR2 and IL-8 in the patients with chronic hepatitis B and their association with IFN therapy. "
|1.||Interleukin-8 (Interleukin 8)
|2.||Messenger RNA (mRNA)
|4.||beta Carotene (Betacarotene)
|8.||Toll-Like Receptors (Toll-Like Receptor)
|10.||G-Protein-Coupled Receptors (Receptors, G Protein Coupled)