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Complementarity Determining Regions (Complementarity Determining Region)

Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
Also Known As:
Complementarity Determining Region; Complementarity Determining Region 1; Complementarity Determining Region 2; Complementarity Determining Region 3; Complementarity Determining Region I; Complementarity Determining Region II; Complementarity Determining Region III; Complementarity-Determining Region; Complementarity-Determining Region 3; Hypervariable Region, Immunoglobulin; Hypervariable Regions, Immunoglobulin; Third Complementarity-Determining Region; Complementarity-Determining Region 3s; Complementarity-Determining Region, Third; Complementarity-Determining Regions; Complementarity-Determining Regions, Third; Immunoglobulin Hypervariable Region; Immunoglobulin Hypervariable Regions; Region, Complementarity Determining; Region, Immunoglobulin Hypervariable; Regions, Complementarity Determining; Regions, Complementarity-Determining; Regions, Immunoglobulin Hypervariable; Third Complementarity Determining Region; Third Complementarity-Determining Regions
Networked: 242 relevant articles (12 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Matsumoto, Yoh: 5 articles (11/2006 - 05/2002)
2. Stamatopoulos, Kostas: 4 articles (01/2013 - 01/2007)
3. Mozes, E: 4 articles (09/2004 - 02/2000)
4. Polonelli, Luciano: 3 articles (01/2015 - 01/2010)
5. Travassos, Luiz R: 3 articles (01/2015 - 01/2010)
6. Luider, Theo M: 3 articles (12/2013 - 01/2011)
7. Rosenquist, Richard: 3 articles (12/2010 - 02/2004)
8. Jee, Youngheun: 3 articles (10/2004 - 05/2002)
9. Zinger, H: 3 articles (09/2004 - 02/2000)
10. Yu, Wei: 2 articles (12/2015 - 06/2008)

Related Diseases

1. Residual Neoplasm
2. Infection
01/01/1998 - "Prophylactic administration of a complementarity-determining region derived from a neutralizing monoclonal antibody is effective against respiratory syncytial virus infection in BALB/c mice."
08/01/2014 - "To explore the dominant complementarity-determining regions 3 (CDR3) of CD8(+) T cell populations induced by the infection of this parasite, sequence analysis was performed in this study for CDR3 of CD8(+) T cells from E. "
12/01/2001 - "To study the modifications of the T cell repertoire during an acute viral infection in rainbow trout, we adapted the immunoscope methodology, which consists of spectratyping the complementarity-determining region 3 length of the TCRbeta chain. "
12/15/2007 - "T cell receptor gene analyses of 2 unrelated DRB1*0101-positive patients with HAM/TSP showed similar Vbeta repertoires and amino acid motifs in complementarity-determining region 3. Our data suggest that efficient clonal expansion of virus-specific CD4(+) T cells in patients with HAM/TSP does not simply reflect higher viral burden but rather reflects a rapid turnover caused by preferential infection and/or in vivo stimulation by major histocompatibility complex-peptide complexes."
12/01/2001 - "Using viral hemorrhagic septicemia virus (VHSV), which provokes an acute infection in rainbow trout, we identified skewed complementarity-determining region 3 size profiles for several VbetaJbeta combinations, corresponding to T cell clonal expansions during primary and secondary response to VHSV. "
3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4. Neoplasms (Cancer)
5. Sezary Syndrome (Sezary Erythroderma)

Related Drugs and Biologics

1. Deoxycytidine (CDR)
2. Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)
3. Immunoglobulin G (IgG)
4. DNA (Deoxyribonucleic Acid)
5. Antibodies
6. Oligonucleotides
7. Immunoglobulin E (IgE)
8. gamma-delta T-Cell Antigen Receptors (T-Cell Receptor delta-Chain)
9. omalizumab (Xolair)
10. anti-IgE

Related Therapies and Procedures

1. Transplants (Transplant)
2. Drug Therapy (Chemotherapy)
3. Immunotherapy
4. Bone Marrow Transplantation (Transplantation, Bone Marrow)
5. Splenectomy