CCAAT-Enhancer-Binding Protein-beta

A CCAAT-enhancer-binding protein found in LIVER; INTESTINES; LUNG and ADIPOSE TISSUE. It is an important mediator of INTERLEUKIN-6 signaling.

Also Known As:

23-C-EBP Protein; 40-C-EBP Protein; AGP-EBP Transcription Factor; C-EBP beta; C-EBP-Related Protein 2; C-EBPbeta; CRP2 Protein; IL-6 DBP; IL-6-Dependent DNA Binding Protein; Interleukin-6 Nuclear Factor; LAP Transcription Factor; Liver-Enriched Inhibiting Protein; Liver-Enriched Inhibitory Protein, LIP; 2, C-EBP-Related Protein; AGP EBP Transcription Factor; C EBP Related Protein 2; C EBP beta; C EBPbeta; CCAAT Enhancer Binding Protein beta; IL 6 Dependent DNA Binding Protein; Inhibiting Protein, Liver-Enriched; Interleukin 6 Nuclear Factor; Liver Enriched Inhibiting Protein; Liver Enriched Inhibitory Protein, LIP; Nuclear Factor, Interleukin-6; Protein-beta, CCAAT-Enhancer-Binding; Transcription Factor, AGP-EBP; Transcription Factor, LAP; C-EBP-beta; NF-IL6

Networked: 427 relevant articles (5 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Johnson, Peter F: 7 articles (05/2009 - 01/2002)
2.	Leutz, Achim: 5 articles (03/2010 - 01/2004)
3.	Kim, Sang Geon: 5 articles (04/2009 - 02/2005)
4.	Akira, Shizuo: 4 articles (01/2010 - 10/2007)
5.	Damm, Jelena: 3 articles (11/2017 - 02/2011)
6.	Gerstberger, Rüdiger: 3 articles (11/2017 - 02/2011)
7.	Roth, Joachim: 3 articles (11/2017 - 02/2011)
8.	Rummel, Christoph: 3 articles (11/2017 - 02/2011)
9.	Timchenko, Nikolai A: 3 articles (07/2010 - 05/2005)
10.	Duyster, Justus: 3 articles (05/2010 - 09/2006)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2008 - "These results indicate that C/EBPbeta represses p53 to promote cell survival downstream of DNA damage and suggest that inhibition of C/EBPbeta may be a target for cancer cotherapy to increase the efficacy of alkylating chemotherapeutic agents." 01/01/2021 - "Recent studies suggest that C/EBPβ (CCAAT-enhancer binding protein beta) and STAT3 synergistically stimulate cancer cell proliferation and epithelial-mesenchymal transition. " 08/01/2015 - "Recently, CCAAT/enhancer binding protein beta (C/EBPβ) has been investigated as a tumor suppressor that participates in tumor invasion. " 08/01/2010 - "Furthermore, the expression of the tumor suppressor p53 and the cell cycle inhibitors p21 and p27 was markedly elevated in C/EBPbeta-null stromal cells before the mitotic phase, uncovering additional mechanisms by which C/EBPbeta controls G2 to M transition. " 10/01/2009 - "Moreover, we found that C/EBPbeta expression was regulated at the post-transcriptional level and correlated with sustained reduction of microRNA-155 (miR-155) in tumor-activated monocytes. "
2.	Carcinogenesis 01/18/2007 - "Recent studies have identified roles for C/EBPbeta in cellular survival and tumorigenesis, however, the mechanisms through which C/EBPbeta regulates these processes are not fully understood. " 12/01/2006 - "C/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression." 02/23/2006 - "Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis." 01/08/2002 - "CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling." 02/23/2006 - "In contrast, mice lacking the related gene, C/EBP delta, were not resistant to DMBA-induced skin tumorigenesis, indicating a unique role of C/EBP beta in skin tumor development. "
3.	Atherosclerosis 03/16/2007 - "Our work uncovers a novel role for C/EBPbeta as a mediator of PPARdelta-dependent 14-3-3epsilon gene regulation in human endothelial cells and provides insight into the mechanism by which PPARdelta agonists may be beneficial in atherosclerosis." 01/01/2020 - "CCAAT/enhancer-binding protein beta (C/EBPβ) is a transcription factor, and its inhibition has recently been shown to prevent atherosclerosis development and foam cell formation. " 09/01/2010 - "Changes in atherosclerosis were paralleled by changes in the expression of the inflammation markers (C-reactive protein, monocyte chemotactic protein-1, interleukin-6, nuclear factor kappa B and intercellular adhesion molecule-1) in peritoneal macrophages obtained from these mice. " 09/14/2007 - "These results, confirmed in primary human hepatocytes and CASMC, demonstrate for the first time that IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation and suggest that IL-17 may mediate chronic inflammation, atherosclerosis, and thrombosis."
4.	Acute Promyelocytic Leukemia 04/01/2004 - "A new role for C/EBPbeta in acute promyelocytic leukemia." 10/16/2009 - "In acute promyelocytic leukemia (APL) cells, C/EBPbeta activity is known to be required for all-trans-retinoic acid-induced cell differentiation and disease remission. "
5.	Leukemia 08/28/2009 - "In this study, interactions between C/EBPbeta and either the Abelson murine leukemia viral oncogene homolog 1 (c-Abl) or the Abl-related gene (Arg) were demonstrated in vitro and in vivo with a direct binding assay and by co-immunoprecipitation, respectively. " 12/01/1998 - "In order to identify the downstream genes of NF-IL6 in a monocytic lineage, we combined an inducible expression system with subtraction cloning in a study of murine M1 monocytic leukemia cells. " 02/01/1997 - "This is significantly different from the apparent effects of NF-IL6 in leukemia cells and in fibroblasts. " 11/03/2003 - "We further provide evidence that ATRA mediates a direct increase of C/EBPbeta, only in PML-RARA (promyelocytic leukemia-retinoic acid receptor alpha)-expressing cells. " 01/15/1992 - "This study showed that the expression of NF-IL6 messenger RNA (mRNA) increased markedly during the differentiation to a (mRNA) increased markedly during the differentiation to a macrophage lineage in mouse myeloid leukemia cells M1, human histiocytic leukemia cells U937, promyelocytic leukemia cells HL-60, and human peripheral monocytes. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Proteins (Proteins, Gene)
3.	Tretinoin (Retinoic Acid)
4.	PPAR delta
5.	Pregnenolone Carbonitrile (PCN)
6.	DEAE-Dextran (Pulsar)
7.	Transcription Factors (Transcription Factor)
8.	NF-kappa B (NF-kB)
9.	CCAAT-Enhancer-Binding Protein-alpha
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Therapeutics
2.	Tenotomy
3.	Chemoprevention
4.	Pancreatectomy
5.	Moxibustion